A Visible‐Light‐Promoted C‐H Arylation and Heteroarylation of Uracil Derivatives with Diazoniums in Aqueous Conditions

Abstract

The photoredox synthesis of C-5 (hetero)arylated uracil and uridine substrates with the corresponding diazonium salts is described. The coupling proceeds efficiently without protection of the hydroxyls at the ribose or prefunctionalization of the C5 position at the nucleobase. No transition-metal catalyst is used in this transformation, thereby avoiding metal contamination in the final products. The use of water as the medium also eliminates the impurities caused by the use of organic solvents.