A Visual Circuit Related to the Nucleus Reuniens for the Spatial-Memory-Promoting Effects of Light Treatment

Huang, Xiaodan; Huang, Pengcheng; Huang, Lu; Hu, Zheng-Fang; Liu, Xianwei; Shen, Jiawei; Xi, Yue; Yang, Yan; Fu, Yunwei; Tao, Qian; Lin, Song; Xu, Anding; Xu, Fuqiang; Xue, Tian; So, Kwok‐Fai; Li, Hao‐Hong; Ren, Chaoran

doi:10.1016/j.neuron.2020.10.023

Cited by 65 publications

(69 citation statements)

References 55 publications

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“…Thus, the vLGN regulates the threshold for instinctive defensive actions, depending on the modality of imminent threat and the animal's anticipation of danger in the environment. Our results add to a growing body of evidence that prethalamic long-range inhibitory pathways exert a powerful influence on behavior (Chou et al, 2018;Zhao et al, 2019;Wang et al, 2019;Venkataraman et al, 2019;Huang et al, 2019Huang et al, , 2021Hormigo et al, 2020;Ahmadlou et al, 2021).…”

Section: Discussionsupporting

confidence: 73%

Flexible inhibitory control of visually evoked defensive behavior by the ventral lateral geniculate nucleus

Fratzl

Koltchev

Vissers

et al. 2021

Neuron

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Section: Discussionsupporting

confidence: 73%

Flexible inhibitory control of visually evoked defensive behavior by the ventral lateral geniculate nucleus

Fratzl

Koltchev

Vissers

et al. 2021

Neuron

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“…The lateral geniculate nucleus (LGN) of the thalamus poses one of the main gateways for photic information conveyed from the retina to the rest of the brain. Specifically, the LGN forms a complex of three independent retinorecipient structures: (a) the dorsolateral geniculate nucleus (DLG), with its thalamocortical neurons reaching the primary visual cortex and thus being directly involved in imageforming vision (Sherman, 2005), (b) the intergeniculate leaflet (IGL) implicated in circadian photoentrainment (Albrecht, 2012) (with one of the densest innervation by melanopsin cells; Beier et al, 2021;Brown et al, 2010), but also nonphotic behaviors such as modulation of mood, sleep, spatial memory, and food intake (Fernandez et al, 2020;Huang et al, 2019Huang et al, , 2021Shi et al, 2019), and (c) the ventrolateral geniculate nucleus (VLG) associated with visuomotor and other nonimage-forming functions (Harrington, 1997;Jeannerod & Putkonen, 1971;Legg & Cowey, 1977). The VLG can be further divided into a brain stem input processing medial part (VLGm) and a directly retinorecipient lateral division (VLGl) (Kolmac & Mitrofanis, 2000;Niimi et al, 1963;Takatsuji & Tohyama, 1989).…”

mentioning

confidence: 99%

Intrinsic circadian timekeeping properties of the thalamic lateral geniculate nucleus

Chrobok

Pradel

Janik

et al. 2021

J of Neuroscience Research

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Benefits and risks of the outside world undergo dramatic daily changes governed by the light-dark (LD) cycle. Thus, most, if not all, living organisms developed biological clocks, which enable them not only to react to these cyclic events but also to predict them. In mammals, the central clock is localized in the suprachiasmatic nuclei (SCN) of the hypothalamus (Hastings et al., 2018(Hastings et al., , 2019. Its timekeeping properties are provided by clock cells maintaining a transcription-translation feedback loop (TTFL) of core clock genes whose expressions are regulated by their own protein products in the period of circa 24 hr (Takahashi, 2017).Circadian rhythms on the molecular level are reflected in the daytime

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“…The vLGN has recently been shown to mediate influences of light on mood and learning (Huang et al, 2019(Huang et al, , 2020. The vLGN also regulates defensive responses to visual threats (Fratzl et al, 2021;Salay and Huberman, 2021), but this regulation appears to be independent of its light responses and retinal input (Fratzl et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Layer-specific developmentally precise axon targeting of transient suppressed-by-contrast retinal ganglion cells (tSbC RGCs)

Tien

Badea

Kerschensteiner

2021

Preprint

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The mouse retina encodes diverse visual features in the spike trains of more than 40 retinal ganglion cell (RGC) types. Each RGC type innervates a specific subset of the more than 50 retinorecipient brain areas. Our catalog of RGC types and feature representations is nearing completion. Yet, we know little about where specific RGC types send their information. Furthermore, the developmental strategies by which RGC axons choose their targets and pattern their terminal arbors remain obscure. Here we identify a genetic intersection (Cck-Cre and Brn3cCKOAP) that selectively labels transient Suppressed-by-Contrast (tSbC) RGCs, a member of an evolutionarily conserved functionally mysterious RGC subclass. We find that tSbC RGCs selectively innervate the dorsolateral and ventrolateral geniculate nuclei of the thalamus (dLGN and vLGN), the superior colliculus (SC), and the nucleus of the optic tract (NOT). They binocularly innervate dLGN and vLGN but project only contralaterally to SC and NOT. In each target, tSbC RGC axons occupy a specific sublayer, suggesting that they restrict their input to specific circuits. The tSbC RGC axons span the length of the optic tract by birth and remain poised there until they simultaneously innervate their four targets around postnatal day five. The tSbC RGC axons make no errors in choosing their targets and establish mature stratification patterns from the outset. This precision is maintained in the absence of Brn3c. Our results provide the first map of SbC inputs to the brain, revealing a narrow target set, unexpected laminar organization, target-specific binocularity, and developmental precision.Significance statementIn recent years, we have learned a lot about the visual features encoded by retinal ganglion cells (RGCs), the eye’s output neurons. In contrast, we know little about where RGCs send their information and how RGC axons, which carry this information, target specific brain areas during development. Here, we develop an intersectional strategy to label a unique RGC type, the tSbC RGC, and map its projections. We find that tSbC RGC axons are highly selective. They innervate few retinal targets and restrict their arbors to specific sublayers within these targets. The selective tSbC RGC projection patterns develop synchronously and without trial and error, suggesting molecular determinism and coordination.

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A Visual Circuit Related to the Nucleus Reuniens for the Spatial-Memory-Promoting Effects of Light Treatment

Cited by 65 publications

References 55 publications

Flexible inhibitory control of visually evoked defensive behavior by the ventral lateral geniculate nucleus

Flexible inhibitory control of visually evoked defensive behavior by the ventral lateral geniculate nucleus

Intrinsic circadian timekeeping properties of the thalamic lateral geniculate nucleus

Layer-specific developmentally precise axon targeting of transient suppressed-by-contrast retinal ganglion cells (tSbC RGCs)

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