This article presents the design of low-profile single band antenna on flexible substrate material. The proposed antenna is designed on the polyimide substrate with overall size of 30 mm × 30 mm × 0.2 mm. The designed antenna operates in the frequency range of 5.71 to 5.99 GHz with impedance bandwidth of 4.8% and covers the Industrial Scientific Medical band for medical body area network applications. The antenna is enabled by placing artificial magnetic conductor (AMC) with two by two array elements under the ground plane. The AMC structure acts as an isolation for the ground plane and main radiator to reduce back radiation. Compared with literature in the wearable antenna designs, the proposed antenna is compact in structure with high gain of 8.31 dBi with AMC-backed structure. The specific absorption rate values are observed by placing the antenna on the three-layered human body model and the observed values are 1.26 and 0.72 W/Kg without AMC and with AMC, respectively. The obtained values are in conjunction with ICNIRP standards, that is, 2 W/Kg should be averaged over 10 g of tissue. The proposed antenna can be used for the smart clothing and wearable electronics applications.