BackgroundInformation on the knowledge of, and attitudes and practices towards epilepsy of the general population in Thailand is still limited, particularly with respect to the differences between populations in municipal and nonmunicipal areas.MethodsA descriptive cross-sectional survey was conducted in a sample population of 1,000, with 500 participants each from municipal and nonmunicipal areas, in the Khon Kaen district.ResultsThe participants in the municipal area had higher incomes and higher education than did the participants in the nonmunicipal area. Both groups had low knowledge regarding epilepsy definition, causes, and treatment, but participants in the municipal area were more knowledgeable on the causes, types, and treatment of epilepsy. With respect to attitude, there were a significantly higher number of nonmunicipal participants than municipal participants who thought epilepsy was a disgusting disorder or that persons with epilepsy were sinful, had brain damage, and could not attend school. The municipal participants showed greater knowledge of correct practice than did nonmunicipal participants with regard to the following: not driving a car; avoiding acrobatic sports, fighting, or water sport; able to eat pork, not having to resign from work; not having to quit school; and able to have sexual relations.ConclusionThe participants from the municipal area had better knowledge, attitudes, and practices than did the participants from the nonmunicipal area. A campaign should be carried out to promote knowledge and understanding of, and practices towards epilepsy. Different emphases should be placed on the two groups of populations and different strategies used.