A whey-predominant formula induces fecal microbiota similar to that found in breast-fed infants

Rochat, Florence; Cherbut, Christine; Barclay, Denis; Puccio, Giuseppe; Fazzolari-Nesci, A.; Grathwohl, Dominik; Haschke, Ferdinand

doi:10.1016/j.nutres.2007.09.008

Cited by 6 publications

(5 citation statements)

References 34 publications

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“…The standard deviation (SD) of bifidobacteria counts quantified by FISH in a previous study was 0.7 log CFU/g (14). To demonstrate equivalence with delta ¼ 0.7 log CFU/g, statistical power ¼ 90%, significance level ¼ 2.5% following Bonferroni adjustment, and an equivalence margin of 0.7 to À0.7 log CFU/mL, n ¼ 32 per group would be required.…”

Section: Statistical Analysesmentioning

confidence: 98%

“…Sample size calculation was based on the primary outcome of demonstrating equivalence in the 2-month bifidobacteria counts in infants fed the study formula with or without B longum BL999 and a difference in the 2-month bifidobacterial counts between infants fed the study formula and those fed the control formula. The standard deviation (SD) of bifidobacteria counts quantified by FISH in a previous study was 0.7 log CFU/g (14). To demonstrate equivalence with delta ¼ 0.7 log CFU/g, statistical power ¼ 90%, significance level ¼ 2.5% following Bonferroni adjustment, and an equivalence margin of 0.7 to À0.7 log CFU/mL, n ¼ 32 per group would be required.…”

Section: Statistical Analysesmentioning

confidence: 98%

“…These distinctions are believed to contribute to the differences in bifidogenic effect (an increase in the total number of bifidobacteria). Studies have suggested an effect of whey‐predominant formulas on the development of infant gut microbiota in a manner that is similar to that of breast‐fed infants (13,14).…”

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confidence: 99%

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Effect of Formula Composition on the Development of Infant Gut Microbiota

Hascoët¹,

Hubert²,

Rochat

et al. 2011

J. pediatr. gastroenterol. nutr.

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Section: Statistical Analysesmentioning

confidence: 98%

Section: Statistical Analysesmentioning

confidence: 98%

See 1 more Smart Citation

Effect of Formula Composition on the Development of Infant Gut Microbiota

Hascoët¹,

Hubert²,

Rochat

et al. 2011

J. pediatr. gastroenterol. nutr.

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“…Two studies conducted in South Africa [23,24] involved infants born to mothers who were diagnosed with HIV, and 3 other studies (in Australia [25] , Italy [26,27] and the United States [28] ) were of infants whose mothers were not diagnosed as having HIV infection ( table 1 ). With the exception of maternal HIV status, the 5 trials had similar inclusion and exclusion criteria.…”

Section: Studied Infant Populationsmentioning

confidence: 99%

The Effect of <i>Bifidobacterium lactis</i> on the Growth of Infants: A Pooled Analysis of Randomized Controlled Studies

2009

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Background/Aims: Breast milk is the best source of nutrition for the growth of the newborn infant. It is therefore essential that mothers who cannot breastfeed or choose not to are provided with alternatives that closely match the composition and functionality of breast milk. This study aimed to investigate the growth effects of probiotic-supplemented formulas on both healthy and vulnerable populations of infants. Methods: A meta-analysis of data from 5 randomized controlled clinical trials that included infants fed formulas containing a probiotic Bifidobacterium lactis CNCM I-3446 was performed (n = 525). A sub-analysis was performed among infants of HIV-positive mothers (n = 120). Growth measurements (gain in weight and body mass index, BMI, from enrollment to 120 days) were compared between infants fed a formula containing B. lactis and those fed a control formula. Changes in length and Z-scores were also compared. Results: Formula with B.lactis was demonstrated to be at least as good as formula without B. lactis in the meta-analysis of 5 studies. The lower boundary of the 95% confidence interval (CI) of the differences in mean weight gain (95% CI 0.09–2.93 g/day) was above the predefined non-inferiority margin of –3.0 g/day. Moreover, among infants with HIV-positive mothers, weight gain of those taking B. lactis was significantly higher than of those not taking B. lactis, by 3.1 g/day (95% CI 0.4–5.8 g/day, p = 0.0226) and the BMI gains were significantly higher, by 6.4 g/m²/day (95% CI 0.0.3–12.5 g/m²/day, p = 0.0400). The corresponding weight for age and BMI Z-scores were also significantly higher, by 0.37 (95% CI 0.03–0.71, p = 0.0308) and by 0.42 (95% CI 0.02–0.83, p = 0.0377), respectively, whereas differences in length gain or length-for-age Z-score were not significant. Among infants in the non-HIV mothers group, there were no significant differences between infants fed formulas with or without B. lactis, for any of the growth parameters. Conclusions: The analysis suggests that B. lactis may have a positive effect on growth in vulnerable populations, specifically in infants born to mothers with HIV.

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“…The study demonstrated that on day 14, whey formula induced a faecal flora closer to that of breastfed babies compared with casein-predominant formula. 41,42…”

Section: Whey Casein Ratiomentioning

confidence: 99%

Common gastrointestinal distress among infants: Role of optimal nutritional interventions

Kesavelu

Sethi

Bangale

et al. 2018

Clinical Epidemiology and Global Health

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The immature gastrointestinal (GI) tract makes infants vulnerable to transient disorders including colic, gastro-oesophageal reflux (GER) and constipation. These conditions cause a significant distress to infants and caregivers, and are among the most common reasons for the paediatrician referral. In addition, these conditions are associated with a significant morbidity, hospitalisations and high healthcare costs, adding to the burden of the disease. Although they are additions to the ongoing physiological development or arise from maladaptive behavioural responses, the evidence remains limited. The vague aetiology and the self-limiting nature, has devoid these conditions of robust clinical attention, both in the research and clinical practice. Frequent early-life intestinal insults may translate as a risk factor in the development of chronic GI disorders and psychological problems later in life. Emerging evidence suggests that providing an optimal nutritional intervention closer to the breast milk can be a path breaking approach to manage these frequently encountered conditions and aid the growth and development of infants.

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A whey-predominant formula induces fecal microbiota similar to that found in breast-fed infants

Cited by 6 publications

References 34 publications

Effect of Formula Composition on the Development of Infant Gut Microbiota

Effect of Formula Composition on the Development of Infant Gut Microbiota

The Effect of <i>Bifidobacterium lactis</i> on the Growth of Infants: A Pooled Analysis of Randomized Controlled Studies

Common gastrointestinal distress among infants: Role of optimal nutritional interventions

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