Effect of Formula Composition on the Development of Infant Gut Microbiota

Hascoët, Jean Michel; Hubert, C.; Rochat, Florence; Legagneur, Henryse; Gaga, Simona; Emady-Azar, Shahram; Steenhout, Philippe

doi:10.1097/mpg.0b013e3182105850

Cited by 99 publications

(101 citation statements)

References 26 publications

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“…Such an intervention is therefore likely not to compensate for differences in microbiota composition observed between breast-and formula feeding. This is in contrast to some cultivation-based studies in which bifidobacteria intervention accounted for changes in early life fecal bacterial composition (11,32). Although the F2 and BF2 groups significantly differed from the B, F+, and BF+ groups at month 1, these differences disappeared over time.…”

Section: Discussioncontrasting

confidence: 50%

Randomized controlled trial on the impact of early-life intervention with bifidobacteria on the healthy infant fecal microbiota and metabolome

Bazanella

Maier²,

Clavel

et al. 2017

The American Journal of Clinical Nutrition

140

150

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Background: Early-life colonization of the intestinal tract is a dynamic process influenced by numerous factors. The impact of probioticsupplemented infant formula on the composition and function of the infant gut microbiota is not well defined. Objective: We sought to determine the effects of a bifidobacteriacontaining formula on the healthy human intestinal microbiome during the first year of life. Design: A double-blind, randomized, placebo-controlled study of newborn infants assigned to a standard whey-based formula containing a total of 10 7 colony-forming units (CFU)/g of Bifidobacterium bifidum, Bifidobacterium breve, Bifidobacterium longum, B. longum subspecies infantis (intervention), or to a control formula without bifidobacteria (placebo). Breastfed controls were included. Diversity and composition of fecal microbiota were determined by 16S ribosomal RNA gene amplicon sequencing, and metabolite profiles were analyzed by ultrahigh-performance liquid chromatography-mass spectrometry over a period of 2 y. Results: Infants (n = 106) were randomly assigned to either the interventional (n = 48) or placebo (n = 49) group; 9 infants were exclusively breastfed throughout the entire intervention period of 12 mo. Infants exposed to bifidobacteria-supplemented formula showed decreased occurrence of Bacteroides and Blautia spp. associated with changes in lipids and unknown metabolites at month 1. Microbiota and metabolite profiles of intervention and placebo groups converged during the study period, and long-term colonization (24 mo) of the supplemented Bifidobacterium strains was not detected. Significant differences in microbiota and metabolites were detected between infants fed breast milk and those fed formula (P , 0.005) and between infants birthed vaginally and those birthed by cesarean delivery (P , 0.005). No significant differences were observed between infant feeding groups regarding growth, antibiotic uptake, or other health variables (P . 0.05). Conclusion:The supplementation of bifidobacteria to infant diet can modulate the occurrence of specific bacteria and metabolites during early life with no detectable long-term effects. This trial was registered at germanctr.de as DRKS00003660. Am J Clin Nutr 2017;106: 1274-86.

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Section: Discussioncontrasting

confidence: 50%

Randomized controlled trial on the impact of early-life intervention with bifidobacteria on the healthy infant fecal microbiota and metabolome

Bazanella

Maier²,

Clavel

et al. 2017

The American Journal of Clinical Nutrition

140

150

View full text Add to dashboard Cite

show abstract

“…Breast-feeding reduced the genotype-related differences in microbiota composition associated with higher risk whereas formula feeding did not (Palma et al, 2012). A modified formula containing whey protein, lower phosphate, and protein, more similar to human milk, did promote Bifidobacterium colonization (Hascoet et al, 2011). However the recent discovery of immune-modulatory motifs in the metagenome of human milk indicates another level of complexity in the immunomodulatory effects of human milk.…”

Section: Role Of Nutrition In the Development Of The Microbiotamentioning

confidence: 97%

Malnutrition, Immunodeficiency, and Mucosal Infection

Herzog

Cunningham‐Rundles

2015

Mucosal Immunology

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“…formula vs. breast milk) [30,31,33,114,115]. Caesarean section-born infants, for example, undergo delayed colonization with an altered flora compared to vaginally delivered infants [31].…”

Section: Postnatal Development Of the Intestinal Microbiotamentioning

confidence: 99%

Establishment of intestinal homeostasis during the neonatal period

Stockinger

Hornef

Chassin

2011

Cell. Mol. Life Sci.

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The intestinal mucosa faces the challenge of regulating the balance between immune tolerance towards commensal bacteria, environmental stimuli and food antigens on the one hand, and induction of efficient immune responses against invading pathogens on the other hand. This regulatory task is of critical importance to prevent inappropriate immune activation that may otherwise lead to chronic inflammation, tissue disruption and organ dysfunction. The most striking example for the efficacy of the adaptive nature of the intestinal mucosa is birth. Whereas the body surfaces are protected from environmental and microbial exposure during fetal life, bacterial colonization and contact with potent immunostimulatory substances start immediately after birth. In the present review, we summarize the current knowledge on the mechanisms underlying the transition of the intestinal mucosa during the neonatal period leading to the establishment of a stable, life-long host-microbial homeostasis. The environmental exposure and microbial colonization during the neonatal period, and also the influence of maternal milk on the immune protection of the mucosa and the role of antimicrobial peptides, are described. We further highlight the molecular mechanisms of innate immune tolerance in neonatal intestinal epithelium. Finally, we link the described immunoregulatory mechanisms to the increased susceptibility to inflammatory and infectious diseases during the neonatal period.

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Effect of Formula Composition on the Development of Infant Gut Microbiota

Abstract: This study showed that infant formula closer resembling human milk was more bifidogenic than the control formula and led to a microbiota profile similar to that for breast-fed infants.

Cited by 99 publications

References 26 publications

Randomized controlled trial on the impact of early-life intervention with bifidobacteria on the healthy infant fecal microbiota and metabolome

Randomized controlled trial on the impact of early-life intervention with bifidobacteria on the healthy infant fecal microbiota and metabolome

Malnutrition, Immunodeficiency, and Mucosal Infection

Establishment of intestinal homeostasis during the neonatal period

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