A widely tunable, near-infrared laser-based trace gas sensor for hydrogen cyanide (HCN) detection in exhaled breath

Azhar, Mohiudeen; Mandon, Julien; Neerincx, Anne H.; Liu, Z.; Mink, J.; Merkus, Peter; Cristescu, Simona M.; Harren, F.J.M.

doi:10.1007/s00340-017-6842-4

Cited by 25 publications

(9 citation statements)

References 36 publications

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“…Furthermore, any concentration can be determined as long as there is a reference line shape from a gas sample. This procedure can also be used for line multiplets, congested lines, or complete vibrational bands and have been successfully applied previously [29,33,34].…”

Section: Resultsmentioning

confidence: 99%

Intensity enhancement in off-axis integrated cavity output spectroscopy

et al. 2018

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Article 25fa pilot End User Agreement This publication is distributed under the terms of Article 25fa of the Dutch Copyright Act (Auteurswet) with explicit consent by the author. Dutch law entitles the maker of a short scientific work funded either wholly or partially by Dutch public funds to make that work publicly available for no consideration following a reasonable period of time after the work was first published, provided that clear reference is made to the source of the first publication of the work. This publication is distributed under The Association of Universities in the Netherlands (VSNU) 'Article 25fa implementation' pilot project. In this pilot research outputs of researchers employed by Dutch Universities that comply with the legal requirements of Article 25fa of the Dutch Copyright Act are distributed online and free of cost or other barriers in institutional repositories. Research outputs are distributed six months after their first online publication in the original published version and with proper attribution to the source of the original publication. You are permitted to download and use the publication for personal purposes. All rights remain with the author(s) and/or copyrights owner(s) of this work. Any use of the publication other than authorised under this licence or copyright law is prohibited. If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons.

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Section: Resultsmentioning

confidence: 99%

Intensity enhancement in off-axis integrated cavity output spectroscopy

et al. 2018

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“…In addition, the exhaled air has a relative high humidity, which might introduce measurement errors, the absorption bands of water molecules should be avoid for highly sensitive detection. According to the HITRAN molecular spectroscopic absorption database [33], the CO 2 molecule shows several strong absorption bands in the near-infrared spectral regions, and the absorption line centered at 1579 nm was selected as the optimum target line [34,35]. Figure 1 depicts the absorption spectra of CO 2 , H 2 O and O 2 at atmospheric pressure and 296 K. It is evident that the spectral line intensity of CO 2 located at 1579.57 nm (6330.82 cm −1 ) is determined to be 1.5×10 −23 cm −1 /(molec•cm −2 ), meanwhile, the line intensities of O 2 and H 2 O is 4.5×10 −31 cm −1 /(molecule•cm −2 ) and 1.6×10 −27 cm −1 /(molecule•cm −2 ), ∼7 and 4 orders of magnitude lower than that of CO 2 , respectively.…”

Section: Line Selectionmentioning

confidence: 99%

Near-infrared tunable diode laser absorption spectroscopy-based determination of carbon dioxide in human exhaled breath

Lou

Jing

Wang

et al. 2019

Biomed. Opt. Express

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A spectroscopic detection system for the accurate monitoring of carbon dioxide (CO 2 ) in exhaled breath was realized by tunable diode laser absorption spectroscopy (TDLAS) in conjunction with a vertical-cavity surface-emitting laser (VCSEL) and a multipass cell with an effective optical path-length of 20 m. The VCSEL diode emitting light with an output power of 0.8 mW, covered the strong absorption line of CO 2 at 6330.82 cm −1 by drive-current tuning. The minimum detectable concentration of 0.769% for CO 2 detection was obtained, and a measurement precision of approximately 100 ppm was achieved with an integration time of 168 s. Real-time online measurements were carried out for the detection of CO 2 expirograms from healthy subjects, different concentrations were obtained in dead space and alveolar gas. The exhaled CO 2 increased significantly with the increasing physical activity, reaches its maximal value at the beginning of respiratory compensation and then decreased slightly until maximal exercise. The developed measurement system has a great potential to be applied in practice for the detection of pulmonary diseases associated with CO 2 retention.

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“…This method has been evaluated and implemented previously to find the detection limit of spectroscopic techniques, e.g. in [14,21,[47][48][49].…”

Section: Detection Limits and Long-term Stabilitymentioning

confidence: 99%

Experimental-based comparison between off-axis integrated cavity output spectroscopy and multipass-assisted wavelength modulation spectroscopy at 77 µm

et al. 2019

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A mid-infrared trace gas detection system based on off-axis integrated cavity output spectroscopy (OA-ICOS) is demonstrated for accurate and sensitive detection of N 2 O in combination with a continuous wave external-cavity quantum cascade laser (EC-QCL) working around 7.7 µm. A 13-times improvement in signal-to-noise ratio is achieved using a re-injection mirror and a minimum detection limit of 70 ppbv in less than 10 s averaging time is achieved, which yields a noise-equivalent absorption sensitivity (NEAS) of 6×10 −9 cm −1 Hz −1/2 . For comparison, a compact multipass cell is deployed to measure the same absorption line of N 2 O using wavelength modulation spectroscopy with second harmonic detection (WMS-2f). An enhancement factor of 20 in comparison to direct absorption spectroscopy (DAS) is achieved, yielding a minimum detection limit of 15 ppbv in less than 10 s averaging and a NEAS of 1×10 −9 cm −1 Hz −1/2 . A comprehensive comparison between the two systems is carried out in terms of residual amplitude noise (RAM), linearity, long-term stability, detection limit, spectral fitting, reproducibility, and background variations. The proposed sensor based on OA-ICOS is potentially advantageous for trace gas sensing in outdoor applications and harsh environments due to its robustness and flexibility of alignment.

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A widely tunable, near-infrared laser-based trace gas sensor for hydrogen cyanide (HCN) detection in exhaled breath

Cited by 25 publications

References 36 publications

Intensity enhancement in off-axis integrated cavity output spectroscopy

Intensity enhancement in off-axis integrated cavity output spectroscopy

Near-infrared tunable diode laser absorption spectroscopy-based determination of carbon dioxide in human exhaled breath

Experimental-based comparison between off-axis integrated cavity output spectroscopy and multipass-assisted wavelength modulation spectroscopy at 77 µm

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