A Y(III)-based Metal–Organic Framework as a Carrier in Chemodynamic Therapy

Abstract

A biocompatible Y­(III)-based metal–organic framework [Y4(TATB)2]·(DMF)3.5·(H2O) (ZJU-16, H3TATB= 4,4′,4′′-(1,3,5-triazine-2,4,6-triyl) tribenzoic acid) was synthesized, and it was adopted to load Mn2+ for chemodynamic therapy. Meanwhile, ibuprofen sodium (IBUNa), an anti-inflammatory drug, was introduced to increase the amount of Mn2+ (about 5.66 wt %) due to the low loading capacity of Mn2+. Mn&IBUNa@ZJU-16 which was loaded by Mn2+ and IBUNa exhibited significant effects of chemodynamic therapy and excellent inhibition of the 4T1 tumor cell growth, implying its long-term prospects in chemodynamic therapy and its possibility in bimodal cancer therapy.

Synthesis, characterizations and kinetics of MOF‐5 as herbicide vehicle and its controlled release in PVA/ST biodegradable composite membranes

“…In the case of pure MOF-5, sharp intensity diffraction peaks centered at about 6.7°, 8.6°, 9.5°, 9.8°, 11.5°, 12.7°, 13.2°, 15.3°, 16.56°, 17.8°were detected, which were consistent with the simulated pattern of MOF-5 and reported results. 21 In the sample of AT @ MOF-5 hybrids, all the diffraction peaks were composed of that of AT and AT@MOF-5, the intensity of all the peaks was reduced, which indicated the presence of the herbicide on the surface as well as inside the cavity of MOF-5. From the XRD results of the membrane, it can be found that the characteristic diffraction peaks of amorphous nature of the PVA/ST membrane.…”

“…Metal-organic frameworks possess controllable pore size and shape, large specific surface area, and high porosity, which makes them have good adsorption properties. [5][6][7][8][9][18][19][20][21][22] MOF-5 is a kind of the most typical representative of the MOFs, which uses phthalic acid and Zn ions as the organic ligands and the metallic sites. [10,11] More recently, MOF-5 has been widely studied in gas storage and separation, drug delivery vehicle and adsorption materials.…”

A nanosized anionic MOF with rich thiadiazole groups for controlled oral drug delivery

“…The modular nature of MOFs endows them with powerful tunability of pore structure and chemistry, thus popularizing their applications including gas separation [ [5] , [6] , [7] , [8] ], [ [5] , [6] , [7] , [8] ] sensing [ [9] , [10] , [11] , [12] ] and catalysis [ 13 , 14 ]. Particularly, tremendous potentials of MOF materials have been exhibited as drug carriers [ [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] ] since MIL-101 was explored for the first time in 2006 by Ferey and co-workers [ 27 ]. Growing evidence has shown that the properties of MOFs highly depend on their crystal size and surface functionalities [ 28 , 29 ].…”

Three Zn(II) coordination polymers as dual‐responsive luminescent probes for highly selective detection of Fe3+ cation and MnO4− anion

“…[11] Hence, exploring a more convenient, practical, and economical detection method has become an urgent problem to be solved. [12][13][14] Luminescent coordination polymers (LCPs), due to the diversity of their structures and wide application in electrochemistry, catalysis, energy storage, and luminescence sensors, have attracted more and more attention. [15][16][17][18][19][20][21][22] It is well known that the specific CPs with different properties can be constructed by the dual-ligand coordination assemblies' strategy.…”