A γ-cyclodextrin-based metal–organic framework embedded with graphene quantum dots and modified with PEGMA <i>via</i> SI-ATRP for anticancer drug delivery and therapy

Jia, Qiaojuan; Li, Zhenzhen; Guo, Chuanpan; Huang, Xiaoyu; Song, Yingpan; Zhou, Nan; Wang, Minghua; He, Linghao; Du, Miao

doi:10.1039/c9nr06195a

Cited by 105 publications

(47 citation statements)

References 55 publications

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“…The UiO-68-azo compound showed favorable stimuli-responsive without any premature drug release 240 . Based on the low pH of micro-environment in tumor, the pH responsive poly dimethacrylate was grafted by surface reaction to manufacture the PEGMA@GQDs@ γ -CD-MOF which provided a platform for valid DOX delivery and neoplasm growth suppression both in vitro and in vivo 241 . Furthermore, high temperatures facilitate drug released 242 .…”

Section: Applications Of Mofs In Therapy and Drug Deliverymentioning

confidence: 99%

Metal-organic frameworks for advanced drug delivery

et al. 2021

Acta Pharmaceutica Sinica B

292

116

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Metal-organic frameworks (MOFs), comprised of organic ligands and metal ions/metal clusters via coordinative bonds are highly porous, crystalline materials. Their tunable porosity, chemical composition, size and shape, and easy surface functionalization make this large family more and more popular for drug delivery. There is a growing interest over the last decades in the design of engineered MOFs with controlled sizes for a variety of biomedical applications. This article presents an overall review and perspectives of MOFs-based drug delivery systems (DDSs), starting with the MOFs classification adapted for DDSs based on the types of constituting metals and ligands. Then, the synthesis and characterization of MOFs for DDSs are developed, followed by the drug loading strategies, applications, biopharmaceutics and quality control. Importantly, a variety of representative applications of MOFs are detailed from a point of view of applications in pharmaceutics, diseases therapy and advanced DDSs. In particular, the biopharmaceutics and quality control of MOFs-based DDSs are summarized with critical issues to be addressed. Finally, challenges in MOFs development for DDSs are discussed, such as biostability, biosafety, biopharmaceutics and nomenclature.

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Section: Applications Of Mofs In Therapy and Drug Deliverymentioning

confidence: 99%

Metal-organic frameworks for advanced drug delivery

et al. 2021

Acta Pharmaceutica Sinica B

292

116

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“…Then, tumor is targeted by the DDRS-loaded drugs through ligand-receptor interactions. Finally, antitumor drugs are released from DDRS in the low pH environment of tumor cells for effective tumor ablation [190].…”

Section: Ligand-ph Delivery-release Modementioning

confidence: 99%

Synthesis of graphene quantum dots and their applications in drug delivery

et al. 2020

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This review focuses on the recent advances in the synthesis of graphene quantum dots (GQDs) and their applications in drug delivery. To give a brief understanding about the preparation of GQDs, recent advances in methods of GQDs synthesis are first presented. Afterwards, various drug delivery-release modes of GQDs-based drug delivery systems such as EPR-pH delivery-release mode, ligand-pH delivery-release mode, EPR-Photothermal delivery-Release mode, and Core/Shell-photothermal/magnetic thermal delivery-release mode are reviewed. Finally, the current challenges and the prospective application of GQDs in drug delivery are discussed.

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“…[192] Other types of QDs (e.g., carbon QDs) either in pristine or modified forms were also found suitable delivery vehicles for tumor cellular targeted drug delivery. [193][194][195][196] QDs can be used for drug delivery strategies because they can simply sense the release of therapeutics by a change in the fluorescence of the imaging modality. [197,198] Recently, Su et al could successfully develop red-emissive carbon QDs capable of entering into the nuclei of both cancer cells and cancer stem cells.…”

Section: Qds For Drug Deliverymentioning

confidence: 99%

Quantum Dots: A Review from Concept to Clinic

Kargozar

Hoseini

Milan

et al. 2020

Biotechnology Journal

169

101

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Quantum dots (QDs) are semiconductor materials that have gained great interest due to their unique characteristics like optical properties. They are extensively being used in different areas, including solar cells, light-emitting diodes, laser technology, as well as biological and biomedical applications. In this review, comprehensive information about different aspects of QDs is provided, including their types and classifications, synthesis approaches, in vitro and in vivo toxicity, biological applications, and potentials in clinical applications. With a focus on the biological aspects, the respective in vitro and in vivo studies are collected and presented. Various surface modifications on QDs are discussed as directly influencing their properties like toxicity and optical abilities. Given the promising results, these materials are clinically used for targeted molecular therapy and imaging. However, there are a large number of questions that should be addressed before the wide application of QDs in a clinical setting. Regarding the existing barriers to QDs, suggestions are given and discussed to present an appropriate route for the clinical use of these materials.

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A γ-cyclodextrin-based metal–organic framework embedded with graphene quantum dots and modified with PEGMA via SI-ATRP for anticancer drug delivery and therapy

Abstract: A biocompatible γ-CD-MOF based DDS with high drug loading and full drug release was prepared and effective tumor growth inhibition was achieved in vivo.

Cited by 105 publications

References 55 publications

Metal-organic frameworks for advanced drug delivery

Metal-organic frameworks for advanced drug delivery

Synthesis of graphene quantum dots and their applications in drug delivery

Quantum Dots: A Review from Concept to Clinic

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