A51 Synthesis of phosphonate conjugates of 188Re-DMSA for treatment of bone metastases

Choudhry, Uzma; Blower, Philip J.

doi:10.1097/00006231-200603000-00062

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It also has potential for conjugation to targeting ligands by virtue of its carboxyl groups. The synthesis of the corresponding dianhydride of this complex (15) provides a simple route to functionalization by reaction with amines linked to targeting groups such as phosphonate (29), imidazole (30) and biomolecules (15), while esterification of the complex offers further opportunity for biological targeting. Despite its advantages of ease of synthesis, well-defined structure and biological stability, it suffers from the limitation that, having two separate bidentate ligands, it forms three isomers ( syn-endo , as shown in Fig.…”

Section: Technetium-99m: Small Complexesmentioning

confidence: 99%

Opportunities and Challenges for Metal Chemistry in Molecular Imaging

Southworth

Rosales

Meszaros

et al. 2016

Advances in Inorganic Chemistry

View full text Add to dashboard Cite

The development of medical imaging is a highly multidisciplinary endeavor requiring the close cooperation of clinicians, physicists, engineers, biologists and chemists to identify capabilities, conceive challenges and solutions and apply them in the clinic. The chemistry described in this article illustrates how synergistic advances in these areas drive the technology and its applications forward, with each discipline producing innovations that in turn drive innovations in the others. The main thread running through the article is the shift from single photon radionuclide imaging towards PET, and in turn the emerging shift from PET/CT towards PET/MRI and further, combination of these with optical imaging. Chemistry to support these transitions is exemplified by building on a summary of the status quo, and recent developments, in technetium-99m chemistry for SPECT imaging, followed by a report of recent developments to support clinical application of short lived (Ga-68) and long-lived (Zr-89) positron emitting isotopes, copper isotopes for PET imaging, and combined modality imaging agents based on radiolabelled iron oxide based nanoparticles.

show abstract