Ab0838 comparison of the Characteristics of the Osteoporotic Patients With and Without Rheumatoid Arthritis Through Radiofrequency Echographic Multi Spectrometry

Abstract

BackgroundOsteoporosis is a common bone disease characterized by reduction in bone mass accompanied by microarchitectural changes, resulting in brittle bones and in an increased risk of fractures. Rheumatoid arthritis is a well-known risk factor for the development of osteoporosis. With the introduction of radiofrequency echographic multi spectrometry (REMS), easily evaluation of the lumbar spine bone mineral density (BMD) ultrasound (BMDus) and hip BMDus is possible for early diagnosis of osteoporosis.ObjectivesThe aim of this study is to compare the characteristics of the osteoporotic patients with and without rheumatoid arthritis through radiofrequency echographic multi spectrometry.MethodsA total of 70 patients with osteoporosis were included in the study. 43% of them (30/70) had RA and 57% (40/70) were without RA. Patients were diagnosed with rheumatoid arthritis if they had a score of 6/10 or higher based on 2010 ACR/EULAR classification criteria for RA. Age, body mass index (BMI), lumbar spine BMDus, as well as total hip BMDus and fracture risk score (FRAX) were assessed.ResultsPatients with RA were significantly younger (69.3 ± 6.5 years) than those without RA (76.4 ± 5.0 years) (p = 0.002). BMI values did not differ significantly between the two groups (25.76 ± 4.82 kg/m2 for patients with RA and 27.57 ± 5.37 kg/m2 for patients without RA). Patients with and without RA did not show any significantly differences between BMDus values of L1-L4 (0.629/0.607 g/cm2 for L1, 0.692/0.688 g/cm2 for L2, 0.761/0.743 g/cm2 for L3 and 0.789/0.769 g/cm2 for L4). Patients with RA had higher total lumbar spine T-score (-2.6 ± 0.8 standard deviations) compared to those without RA (-3.1 ± 0.5 standard deviations), but this difference was not significant (p > 0.05). Femoral neck BMDus, trochanteric BMDus and total hip BMDus were similar in the groups with and without RA (0.550/0.548 g/cm2 for femoral neck, 0.710/0.693 g/cm2 for trochanter, 0.688/0.678 g/cm2 for total hip). FRAX score of the patients with RA was significantly higher (32.89% for 10-year probability of major osteoporotic fracture and 14.29% for 10-year probability of hip fracture) compared to the patients without RA (22.36% for 10-year probability of major osteoporotic fracture and 8.75% 10-year probability of hip fracture).ConclusionAlthough there were no significant differences in lumbar spine BMDus values and total hip BMDus values between the patients with and without RA, patients with RA showed higher 10-year probability of major osteoporotic fracture and hip fracture.References[1] Conversano F, Franchini R, Greco A, Soloperto G, Chiriacò F, Casciaro E, Aventaggiato M, Renna MD, Pisani P, Di Paola M, Grimaldi A, Quarta L, Quarta E, Muratore M, Laugier P, Casciaro S (2015) A novel ultrasound methodology for estimating spine mineral density. Ultrasound Med Biol41:281–300[2] Casciaro S, Peccarisi M, Pisani P, Franchini R, Greco A, De Marco T, Grimaldi A, Quarta L, Quarta E, Muratore M, Conversano F (2016) An advanced quantitative echosound methodology for fem...