Ab1231 profile of Osteoporosis in Young Women: Experience From a Population in Southern Morocco

Abstract

BackgroundOsteoporosis is a generalized skeletal disease characterized by low bone density and alterations in bone microarchitecture. Current definitions and recommendations focus more on postmenopausal osteoporosis with a low number of studies in young pré-menopausal women, which makes it difficult to estimate the prevalence of osteoporosis in this population.ObjectivesTo establish the prevalence and determine the etiologies of osteoporosis in young women and their management according to the experience of our department.MethodsRetrospective descriptive and analytical study including 97 female patients aged less than 45 years, who performed a bone densitometry measurement between the years 2014 and 2022. Data were collected from the bone densitometry database. Osteoporosis was retained if a T score less than or equal to -2.5. Women older than 45 years and or followed for genetic osteopathy were excluded from this study.ResultsThere were 97 patients with osteoporosis in this study. The average age was 25 years. Early menopause was found in 15% of cases (10% of cases after chemotherapy). Osteoporosis secondary to endocrinopathy was found in 17% of cases (5% diabetes, 10% primary hyperparathyroidism, 2% Cushing’s syndrome). It was secondary to a systemic disease or chronic inflammatory rheumatism in 45% of cases (29% rheumatoid arthritis, 12% spondyloarthropathy, 3% systemic lupus erythematosus and 1 % Horton’s disease). The other pathologies found were chronic renal failure in 3% of cases, a notion of prolonged use of corticosteroids in 21% and hormone therapy for breast neoplasia in 14%. 3% of the patients had at least one osteoporotic vertebral fracture. The mean bone mineral density (BMD) in both femurs was 0.727g/cm2. The mean BMD in the spine was 0.965g/cm2. 11% of these patients were treated with oral anti-osteoporotic drugs, 35% were supplemented with vitamin D and calcium.ConclusionThe discovery of osteoporosis is rare in young women, hence the scarcity of studies in this category of women. It may be of metabolic or drug-induced origin or related to other chronic inflammatory diseases. It should be investigated in the presence of risk factors in order to limit the risk of bone fractures.Reference[1]Pepe J, Body J, Hadji P, McCloskey E, Meier C, Obermayer-Pietsch B, et al.Osteoporosis in Premenopausal Women: A Clinical Narrative Review by the ECTS and the IOF. The Journal of Clinical Endocrinology & Metabolism. 2020 Aug 1;105(8):2487-506.Acknowledgements:NIL.Disclosure of InterestsNone Declared.