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BackgroundOsteoporosis (OP) is a systemic skeletal disorder characterized by low bone mass responsible of fracture. It is a major public health problem. knowledge assessment is an essential step in therapeutic education which could improve the management of osteoporosis.ObjectivesThe objective of this study is to assess the degree of knowledge of osteoporotic patients regarding their disease as part of therapeutic education in order to improve management and develop a shared decision with the patient.MethodsThis is a cross-sectional epidemiological study conducted on osteoporotic patients at the rheumatology department of the university hospital center Mohamed VI Marrakech. Descriptive data, knowledge evaluation, patient expectations and therapeutic adherence were collected and analysed by SPSS 20. The comparison was made by the Chi-square test for qualitative variables.Results137 patients were included with an average age of 63.7 years, with a female predominance (94.9% female vs 5.1% male), 70.1% were illiterate, 58.4% had postmenopausal OP, 36.5% secondary OP and 5.1 % (n=7) male OP. 14.6% of the patients had diabetes, 9.5% had arterial hypertension, 5.8% had breast cancer under aromatase-inhibitors, 13.9% had rheumatoid arthritis and 9.5% had other chronic diseases, 16.1% were on long-term corticosteroids, 98.5% were on oral bisphosphonate and only 2 patients were on Intravenous zoledronate, 51.1% had osteoporosis for less than 2 years, 9.5% had a history of fracture with 2.9% major fractures.9.5% of patients answered that osteoporosis was linked to bone fragility, 29.2% thought it was age-related, 26.3% had a confusion between osteoporosis and osteoarthritis, 16.8% believed it was an inflammatory rheumatism. 81% supposed it was a female pathology, 92% presumed that their rheumatological manifestations were linked to osteoporosis, 58.4% didn’t know OP’s risk factors, 14.6% and 8.8% had recognized aging and menopause as OP’s risk factors respectively. 59.1% and 61.3% didn’t know any fall nor fracture related factors respectively.Concerning the clinical manifestations of osteoporosis, 48.2% thought OP manifested by arthralgia, 21.2% by myalgia, 2.2% by bone pain and only 5% assumed that it is a silent disease.95.6% assumed that physical activity is harmful and 32.1% had made environmental modifications.52.6% were convinced by their anti-osteoporotic treatment, 32.8% said they trusted the doctor’s decision and 14.6% were not convinced of the treatment but took it anyway.In bivariate analysis, there was a statistically significant correlation (p=0.008) between non-adherence to treatment and poor knowledge of OP’s risk factors.ConclusionThe knowledge evaluation being the first step of therapeutic education, it is necessary to encourage OP’s knowledge improvement and consequently increase therapeutic adherence.References[1]Bousselham S, Nassar K, Janani S. Enquête sur l’évaluation du degré de connaissance des patients ostéoporotiques vis-à-vis de leur maladie. Revue du Rhumatisme. 2021 Dec;88:A313.[2]Lespessailles E, Martaillé V, Beauvais C. Besoins et objectifs éducatifs des patients atteints d’ostéoporose. Revue du Rhumatisme Monographies. 2013 Jun;80(3):157-61.[3]Rousière M. L’ETP améliore-t-elle l’observance: quel bénéfice dans l’ostéoporose?. Revue du Rhumatisme Monographies. 2013 Jun;80(3):166-9.Disclosure of InterestsNone declared

BackgroundOsteoporosis is a generalized skeletal disease characterized by low bone density and alterations in bone microarchitecture. Current definitions and recommendations focus more on postmenopausal osteoporosis with a low number of studies in young pré-menopausal women, which makes it difficult to estimate the prevalence of osteoporosis in this population.ObjectivesTo establish the prevalence and determine the etiologies of osteoporosis in young women and their management according to the experience of our department.MethodsRetrospective descriptive and analytical study including 97 female patients aged less than 45 years, who performed a bone densitometry measurement between the years 2014 and 2022. Data were collected from the bone densitometry database. Osteoporosis was retained if a T score less than or equal to -2.5. Women older than 45 years and or followed for genetic osteopathy were excluded from this study.ResultsThere were 97 patients with osteoporosis in this study. The average age was 25 years. Early menopause was found in 15% of cases (10% of cases after chemotherapy). Osteoporosis secondary to endocrinopathy was found in 17% of cases (5% diabetes, 10% primary hyperparathyroidism, 2% Cushing’s syndrome). It was secondary to a systemic disease or chronic inflammatory rheumatism in 45% of cases (29% rheumatoid arthritis, 12% spondyloarthropathy, 3% systemic lupus erythematosus and 1 % Horton’s disease). The other pathologies found were chronic renal failure in 3% of cases, a notion of prolonged use of corticosteroids in 21% and hormone therapy for breast neoplasia in 14%. 3% of the patients had at least one osteoporotic vertebral fracture. The mean bone mineral density (BMD) in both femurs was 0.727g/cm2. The mean BMD in the spine was 0.965g/cm2. 11% of these patients were treated with oral anti-osteoporotic drugs, 35% were supplemented with vitamin D and calcium.ConclusionThe discovery of osteoporosis is rare in young women, hence the scarcity of studies in this category of women. It may be of metabolic or drug-induced origin or related to other chronic inflammatory diseases. It should be investigated in the presence of risk factors in order to limit the risk of bone fractures.Reference[1]Pepe J, Body J, Hadji P, McCloskey E, Meier C, Obermayer-Pietsch B, et al.Osteoporosis in Premenopausal Women: A Clinical Narrative Review by the ECTS and the IOF. The Journal of Clinical Endocrinology & Metabolism. 2020 Aug 1;105(8):2487-506.Acknowledgements:NIL.Disclosure of InterestsNone Declared.

BackgroundAir pollution is incriminated in a large number of respiratory and cardiovascular pathologies. More recently, the role of particulate matter from pollution has been studied in autoimmune diseases and in particular in rheumatoid arthritis (RA).ObjectivesThe objective of our study is to evaluate the impact of air pollution measured by the air quality index (AQI) on different disease parameters during rheumatoid arthritis.MethodsWe included in this study 112 patients with seropositive rheumatoid arthritis, residing in different regions of southern Morocco. Inclusion criteria were: established rheumatoid arthritis, duration of residence exceeding one year in the same region. Exclusion criteria were: specific professional exposure to industrial pollutants and passive and active smoking. The air quality was evaluated by the new ATMO index which classifies the air quality in five levels: Good, average, degraded, bad, very bad and extremely bad according to the concentration of the four air pollutants. The following parameters were collected: duration of disease progression, age, number of exacerbations per year, the mean DAS 28 CRP during the last year, the mean CRP during the last year, the use of analgesics, the number of hospitalizations, an univariate and multivariate analysis evaluating the association and the correlation with the different parameters was carried out by the SPSS 2021.Results112 patients were included. The female sex represents 66%. The different regions included in the study were: Marrakech in 68 cases with an AQI of 47, Safi in 9 cases with an AQI of 21, Beni Mellal in 6 cases with an AQI of 29, Sidi Rehal in 1 case with an AQI of 1, Demnate in 2 cases with an AQI of 29, Ouarzazate in 4 cases with an AQI of 25, Azilal in 10 cases with an AQI of 34, Zagora in 4 cases with an AQI of 21, Youssoufia in 1 case with an AQI of 9, Guelmim in 7 cases with an AQI of 17, Semara in 1 case with an AQI of 46. The average DAS 28 was 3.11. The mean CRP was 23.1 mg/l. The average number of hospitalizations during the last year was 2.5. The average number of exacerbations in the last year was 5.6. The use of level 1 analgesic was noted in 22%, level 2 in 13%. A positive correlation was found between the number of exacerbations and AQI (p 0.001, rs 0.67), CRP and AQI (p 0.013, rs 0.71).ConclusionThe associations between rheumatoid arthritis and air pollution seem complex, it can be considered as a risk factor aggravating rheumatoid arthritis, and these hypotheses have to be demonstrated on a larger sample.Reference[1] Ho W, Chou L, Wang R, Doan T, Yu H, Chou T, et al. Association between Exposure to Ambient Air Pollution and the Risk of Rheumatoid Arthritis in Taiwan: A Population-Based Retrospective Cohort Study. IJERPH. 2022 Jun 8;19(12):7006Acknowledgements:NIL.Disclosure of InterestsNone Declared.

BackgroundPsoriatic arthritis (PsA) is a chronic inflammatory rheumatism belonging to the spondyloarthritis. It is characterised by a heterogeneous clinical presentation.ObjectivesThe aim of our work is to evaluate the characteristics of axial involvement in RPso.MethodsRetrospective study of 86 patients followed for RPso in the rheumatology department over a period of 7 years from 2014 to 2021. The patients were divided into 2 groups: group 1 (RPso with axial involvement) and group 2 (RPso without axial involvement).ResultsOur study involved a population of 86 patients with RPso, the average age was 44.7 years with a female predominance (58.6%), 16.1% of the patients were diabetics, 9.3% were hypertensive, 9.3% were smokers and 2.4% had a history of psoriasis in the family. Concerning the clinical manifestations, 95.3% of patients had polyarthralgia, 73.3% had polyarthritis, 29.4% had deformities and 86% had axial involvement. The bivariate analysis allowed us to identify the results summarised in the following Table 1:Table 1.Group 1(74 patients)Group 2(12 patients)P valueWomen (%)63.533.30.04Duration of evolution(years)8.073.50.012Psoriasis (%)39.1250.3Polyarthralgias (%)95.991.60.2enthesic syndrome (%)37.568.80.08Dactylitis (%)6.741.60.003BASDAI >472.9741.60.03Average CRP28.750.60.032NSAIDs (%)40.5750.026Logistic regression analysis identified that patients with axial involvement were more likely to have a longer duration of evolution (OR = 3.5) and elevated CRP (OR = 4.9).ConclusionAxial involvement in our study was present in 86 % of the patients and was associated with a long.duration of evolution and a statistically significant higher average CRP.Reference[1]Mease, P. J., Palmer, J. B., Liu, M., Kavanaugh, A., Pandurengan, R., Ritchlin, C. T.,... & Greenberg, J. D. (2018). Influence of axial involvement on clinical characteristics of psoriatic arthritis: analysis from the Corrona Psoriatic Arthritis/Spondyloarthritis Registry.The Journal of rheumatology,45(10), 1389-1396.Table 1.Univariate analysis to the characteristics of the 2 groups.Acknowledgements:NIL.Disclosure of InterestsNone Declared.