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BackgroundAir pollution is incriminated in a large number of respiratory and cardiovascular pathologies. More recently, the role of particulate matter from pollution has been studied in autoimmune diseases and in particular in rheumatoid arthritis (RA).ObjectivesThe objective of our study is to evaluate the impact of air pollution measured by the air quality index (AQI) on different disease parameters during rheumatoid arthritis.MethodsWe included in this study 112 patients with seropositive rheumatoid arthritis, residing in different regions of southern Morocco. Inclusion criteria were: established rheumatoid arthritis, duration of residence exceeding one year in the same region. Exclusion criteria were: specific professional exposure to industrial pollutants and passive and active smoking. The air quality was evaluated by the new ATMO index which classifies the air quality in five levels: Good, average, degraded, bad, very bad and extremely bad according to the concentration of the four air pollutants. The following parameters were collected: duration of disease progression, age, number of exacerbations per year, the mean DAS 28 CRP during the last year, the mean CRP during the last year, the use of analgesics, the number of hospitalizations, an univariate and multivariate analysis evaluating the association and the correlation with the different parameters was carried out by the SPSS 2021.Results112 patients were included. The female sex represents 66%. The different regions included in the study were: Marrakech in 68 cases with an AQI of 47, Safi in 9 cases with an AQI of 21, Beni Mellal in 6 cases with an AQI of 29, Sidi Rehal in 1 case with an AQI of 1, Demnate in 2 cases with an AQI of 29, Ouarzazate in 4 cases with an AQI of 25, Azilal in 10 cases with an AQI of 34, Zagora in 4 cases with an AQI of 21, Youssoufia in 1 case with an AQI of 9, Guelmim in 7 cases with an AQI of 17, Semara in 1 case with an AQI of 46. The average DAS 28 was 3.11. The mean CRP was 23.1 mg/l. The average number of hospitalizations during the last year was 2.5. The average number of exacerbations in the last year was 5.6. The use of level 1 analgesic was noted in 22%, level 2 in 13%. A positive correlation was found between the number of exacerbations and AQI (p 0.001, rs 0.67), CRP and AQI (p 0.013, rs 0.71).ConclusionThe associations between rheumatoid arthritis and air pollution seem complex, it can be considered as a risk factor aggravating rheumatoid arthritis, and these hypotheses have to be demonstrated on a larger sample.Reference[1] Ho W, Chou L, Wang R, Doan T, Yu H, Chou T, et al. Association between Exposure to Ambient Air Pollution and the Risk of Rheumatoid Arthritis in Taiwan: A Population-Based Retrospective Cohort Study. IJERPH. 2022 Jun 8;19(12):7006Acknowledgements:NIL.Disclosure of InterestsNone Declared.

BackgroundOverweight, translated into a high body mass index (BMI), is associated with a risk of gonarthrosis, thus, this risk is increased by 15% for each increase of a unit of body mass index (BMI). (1)Various studies indicate that the association of high BMI and abdominal obesity measured by waist circumference leads to increased morbidity especially in obese. But no study has so far shown a sufficiently strong association force between waist circumference and gonarthrosis.(2,3)ObjectivesThe objective of our study is to assess the relationship between waist circumference and pain perception and gonarthrosis impact.MethodsThis work included patients followed in consultation for gonarthrosis. For each patient we specified next to the demographic data, the BMI, the waist circumference, and the existence or no pain of the knee or both. The intensity of pain was assessed by the Analog Visual Scale (EVA). Functional impact was assessed by the Lequesne index and Womac score. Knee X-rays were classified according to Kellgren Lawrence (KL) criteria.ResultsA total of 209 patients were included (24 men/185 women). The average age was 57.94± 9.01 years. The average body mass index was 25.15 ±5.47 kg/m2and the average TI was 93.45 ±12.35 cm.The average pain EVA at rest was 1.95 2.53 and at stress 7.89 ±1.30. Womac’s average score was 12.3± 8.92 and Lequesne’s average index was 6.71 3.20.WOMAC SCORE was significantly higher in gonarthrosis patients with a high waist circumference (p = 0.02).A positive correlation was found between the resting and stress pain EVA and the waist circumference of gonarthrosic patients with respectively (p=0.04, p=0.002). but it is statistically insignificant between the radiographic stages, the lesquene index and waist circumference with (p=0.11, p=0.06, respectively).ConclusionThe the waist circumference seems to be a predictive factor of the presence of gonalgie and a significant functional impact.References[1]L.Jiang, W.Tian, Y.Wang and col. Body mass index and susceptibility to osteoarthritis of the knee: meta-analysis. Rev Rhum Engl Ed 2012;2:142-148[2]Canadian Joint Replacement Registry. Total Hip and Total Knee Repla- cements in Canada: 2005 Report. Ottawa, ON: Canadian Institute for Health Information; 2005.[3]Tjepkema M, Shields M. Measured Obesity: Adult Obesity in Canada. Catalogue No. 82–620-XWE2005001 ed. Ottawa: Statistics Canada; 2005.Acknowledgements:NIL.Disclosure of InterestsNone Declared.

BackgroundThe knee osteoarthritis (KOA) pain can be divided into two main categories: pain on walking and pain at rest. A thorough understanding of pain is essential for managing KOA. However, few studies have focused on these two types of pain.ObjectivesThe objective of this study was to investigate possible factors associated with knee osteoarthritis pain with a focus on the differences between pain on walking and pain at rest.MethodsCross-sectional study including 87 patients. All demographic data and visual analog scale (VAS) score at walking, VAS score at rest, Kellgren and Lawrence (KL) stage on radiography, and results of clinical examination were collected. Exclusion criteria were the presence of a total knee prosthesis and patients followed for chronic inflammatory rheumatism. Statistical data analysis was performed using SPSS version 21 software.ResultsThis study included 87 patients followed for KOA, with an average age of 63.67+/-5.8 years (46-83 years), and a female predominance (78.3%). In the univariate analyses, significant correlations were found between the VAS score at walking with age (r=0.56, p=0.037), body mass index (BMI) (r=0.61, p=0.023), KL grade (r=0.54, p=0.039) and patellar shock (r=0.46, p=0.044). While the VAS score at rest was only correlated with BMI (r=0.26, p=0.01). And an association between VAS at rest and skin hyperalgesia was noted (p=0.034).The multivariate analysis showed that the significant explanatory factors of the VAS score on walking were BMI > 25kg/m2 (p=0.03) and KL grade >3 (p=0.03). On the other hand, no significant explanatory factor for the VAS score at rest was found.ConclusionPredisposing factors were significantly different between the two types of pain, indicating the presence of different pain mechanisms. Pain on walking was more strongly associated with mechanical and structural factors, whereas pain at rest was associated with knee hyperalgesia.Reference[1]Satake Y, Izumi M, Aso K, Igarashi Y, Sasaki N, Ikeuchi M. Comparison of Predisposing Factors Between Pain on Walking and Pain at Rest in Patients with Knee Osteoarthritis. JPR. 2021 Apr;Volume 14:1113-8.Acknowledgements:NIL.Disclosure of InterestsNone Declared.

BackgroundOsteoarthritis of the knee, together with that of the hip, is the most serious disease of osteoarthritis.Long considered a benign disease, gonarthrosis is nevertheless associated with significant morbidity.ObjectivesTo assess the prevalence of co-morbidities in gonarthrosis patients and to assess their impact on pain, functional impact and radiographic progression.MethodsOur study involved patients with gonarthrosis. Comprehensive comorbidity screening was done. Pain intensity was assessed by the Analogue Visual Scale (EVA). The neuropathic component was assessed by the DN4 score. Functional impact was assessed by the Lequesne index and Womac score. Knee X-rays were classified according to Kellgren Lawrence (KL) criteria.ResultsA total of 215 patients were included (24 men/191 women). The average age was 58.02 ±9.11 years. The mean body mass index was 24.87± 5.39 kg/m2. The main comorbidities were:COMORBIDITIESPREVALENCEOverweight and obesity40,6%Heart disease37,4%HTA26%Diabetes24,2%Dyslipidemia11.2%Anxiety9,3%Ostéoporosis7,9%Dysthyroidism7%Smoking3,7%Neoplasia1,4%Chronic kidney disease0,9%The visual analogic scale was 7.86± 1.31 and stress at 13.74 ±4.95. The average Womac score was 12.3 ±8.92. The average Lequesne score was 6.71 ±3.20. The average DN4 score was 18.81± 8.9.Comorbidities were associated with age (p = 0.02), DN4 score (p = 0.01), and KL radiographic grades (p = 0.02).ConclusionIn this study, co-morbidity in gonarthrosis was associated with advanced age, a neuropathic component of pain, and severe structural impairment.Reference[1]Comorbidities and osteoarthritis Christian-Hubert Roux, Service de rhumatologie, université Côte d’Azur, LAMHESS, EA 6312, CHU Nice, France,IBV CNRS UMR7277 Inserm, U1091, 06000 Nice, France, revue du rhumatisme 2021Acknowledgements:NIL.Disclosure of InterestsNone Declared.