Abamectin: an uncommon but potentially fatal cause of pesticide poisoning

Bansod, Y. V.; Kharkar, Sandeep V.; Raut, Arshish; Choudalwar, Piyush

doi:10.5455/2320-6012.ijrms20130826

Cited by 9 publications

(11 citation statements)

References 4 publications

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“…Mild toxicity causes nausea, vomiting, diarrhoea, and weakness [2][3][4][5][6]. Moderate toxicity may include dilated pupils, nausea, ptosis, confusion, coma, and seizure [2][3][4][5][6]. Coma, respiratory failure, acidosis, and rarely death may occur in severe intoxication [2].…”

Section: Discussionmentioning

confidence: 99%

“…Human and veterinary uses include treatment of Onchocerca volvulus (the nematode causing river blindness) [1]. The intoxication may cause coma, hypotension, and respiratory failure [2][3][4][5][6]. This case, presented in accord with the CARE guidelines (https://www.carestatement.org/), illustrates the clinical features of abamectin toxicity and supportive therapy for outcome of patient.…”

Section: Introductionmentioning

confidence: 99%

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Acute abamectin toxicity: a case report

Pirasath

Nageswaran

Karunasena

et al. 2021

Toxicology Communications

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Acute abamectin toxicity: a case report

Pirasath

Nageswaran

Karunasena

et al. 2021

Toxicology Communications

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“…Evidences of the associations between gastric disorders and pesticide application by rural workers have been reported in the literature. (2)(3)(4)(5)(6) A study involving individuals who applied pesticides reported gastrointestinal symptoms, including nausea, vomiting, severe abdominal pain, and retrosternal pain or discomfort. These symptoms were attributed to gastrointestinal irritation produced by the release of phosphine into the stomach.…”

Section: Introductionmentioning

confidence: 99%

“…(2) Gastric disorders have also been reported in cases of mild intoxication with the pesticide Abamectin. (3) In addition, genetic research on gastric cancer in patients affected by the disease indicated a higher frequency of cancer in patients living in rural environments. Increased exposure to various pesticides in the field could explain the higher rate of gastric cancer in these patients.…”

Section: Introductionmentioning

confidence: 99%

Prevalência de sinais e sintomas digestórios em trabalhadoras rurais e fatores associados

et al. 2015

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Objective: To determine the prevalence of digestive signs and symptoms in rural workers and identify frequently associated factors. Methods: This cross-sectional study included 182 rural and horticultural farm workers aged 18 years or older. To assess internal data consistency, the Cronbach's alpha coefficient was used. To compare means between groups, student's t-test was used for independent samples. The Mann-Whitney test was used in cases of asymmetry. Results: The prevalence of digestive signs and symptoms was 31.9%. The signs and symptoms included epigastric pain (27.4%), regurgitation (18.1%), bloating (9.9%), nausea (9.9%), and vomiting (6.0%). Conclusion: The prevalence of digestive signs and symptoms reported by rural workers was high and was associated with being older than 60 years, using agricultural pesticides, and being of Italian descent. ResumoObjetivo: Conhecer a prevalência de sinais e sintomas digestórios em trabalhadoras rurais e identificar fatores associados mais frequentes. Métodos: Estudo transversal que incluiu 182 trabalhadoras rurais maiores de 18 anos e de agricultura de hortifrutigranjeiros. Para avaliar a consistência interna dos dados utilizou-se o coeficiente alfa de Cronbach. Para comparar médias entre os grupos, o teste t de Student foi aplicado para amostras independentes. Em caso de assimetria, foi utilizado o teste de Mann-Whitney. Resultados: A prevalência de sinais e sintomas digestórios relatados foi 31,9%. Os sinais e sintomas digestórios relatados foram: dor epigástrica (27,4%), regurgitação (18,1%), inchaço (9,9%), náusea (9,9%) e vômitos (6,0%). Conclusão: A prevalência de sinais e sintomas digestórios relatados por trabalhadoras rurais foi alto e esteve associado a idade maior de 60 anos, utilização de pesticidas agrícolas e ascendência italiana.

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“…[ 4 ] Avermectines are new pesticides with a wide margin of safety, however, in severe cases of intoxication cause coma, hypotension, acidosis and even death. [ 7 ] Most patients were poisoned in an attempt to commit suicide by abamectin. [ 8 ] The toxic dose of 30 mg per kg of body weight of the mice was measured in 50% of cases 2.…”

Section: Introductionmentioning

confidence: 99%

Conservative care in successful treatment of abamectin poisoning

Aminiahidashti¹,

Jamali²,

Gorji³

2014

Toxicol Int

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Human intoxication with abamectin is an uncommon but potentially fatal cause of pesticide poisoning. In this study a 42-year-old man was intoxicated with 3600 mg abamectin orally. On admission patient was fully alert with the smell of the poison from the mouth. Vital signs were normal and conjunctiva was hyperemic. Conservative cares such as gastric lavage was performed and charcoal was administered. After 2.5 hours, the patient gradually developed altered mental status as drowsiness, hypotension, tachycardia and dermal erythema. He was treated with H1 and H2 blockers and vasoactive agents and after 2 days was discharged in good condition. In comparison with organophosphates, abamectin intoxication has less risk in humans. However, consumption of large amounts in human can be fatal. Altered mental status could be considered as the first sign of abamectin intoxication. Normal level of consciousness is the best indicator of improvement of the condition. Conservative treatment is recommended.

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Abamectin: an uncommon but potentially fatal cause of pesticide poisoning

Cited by 9 publications

References 4 publications

Acute abamectin toxicity: a case report

Acute abamectin toxicity: a case report

Prevalência de sinais e sintomas digestórios em trabalhadoras rurais e fatores associados

Conservative care in successful treatment of abamectin poisoning

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