ABC Transporters in the Eyes of Dogs and Implications in Drug Therapy

Milanova, Aneliya; Krastev, S.; Santos, Regiane R.; Schrickx, Jan A.; Fink‐Gremmels, Johanna

doi:10.3109/02713683.2012.754903

Cited by 3 publications

(2 citation statements)

References 27 publications

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“…Since previously, no case reports were presented for dogs, the present authors may briefly suggest that species difference might be a confounding factor involving the expression of ABCG2 transporters in dogs [16,17] .…”

Section: Discussionmentioning

confidence: 99%

Aşırı Doz Marbofloksasin: Bir Köpekte Akut Körlük İçin Olağan Şüpheli

Akin¹,

Karademir²,

Belge³

et al. 2016

Kafkas Univ Vet Fak Derg

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In this case report, a 4 year old female terrier crossbred dog was presented with acute blindness following accidental high dose marbofloxacin administration was discussed. On initial referral to the clinic, a respiratory disease was evident, requiring antibiotic therapy and marbofloxacin (2.5 mg/kg) was prescribed. Meanwhile, patient was transferred to another veterinary practitioner specialized in large animal diseases, marbofloxacin had administered at an over dose (1050 mg/total dose through 3 days). The dog was then introduced back to our clinic with acute bilateral blindness. A diagnosis of marbofloxacin toxicity related to an overdose was made based on clinical examination and laboratory findings, excluding other relevant etiology. Dexamethasone was applied as initial treatment. In the following weeks, vision loss was eminent even without responding to bright light and not able to negotiate the obstacle course. According to the current literature, this is the first report on marbofloxacin overdose related acute blindness in dogs. Keywords: Blindness, Marbofloxacin overdose, Dog Aşırı Doz Marbofloksasin: Bir Köpekte Akut Körlük İçin Olağan Şüpheli ÖzetBu olgu sunumunda yanlışlıkla yüksek doz marbofloksasin uygulaması sonucunda 4 yaşlı, dişi, terrier melezi bir köpekte gelişen akut körlük vakası irdelenmiştir. Olgu kliniğe ilk başvurduğunda antibiyotik sağaltımı gerektiren bir solunum yolu enfeksiyonu olduğu belirlendi ve marbofloksasin (2.5 mg/kg) reçete edildi. Bu süre içerisinde, büyük hayvan hastalıkları konusunda uzmanlaşmış bir veteriner hekime götürülmüş ve marbofloksasin 3 gün boyunca aşırı dozda (1050 mg/3 gün boyunca toplam doz) uygulanmıştır. Köpek, uygulama sonrasında tekrar kliniğimize getirildiğinde akut körlük mevcuttu. Marbofloksasin toksisite tanısı, diğer ilişkili etiyoloji haricinde klinik, labaratuvar bulgular ve ilacın aşırı doz alımı temel alınarak konuldu. İlk sağaltım uygulaması olarak deksametazon uygulandı. Takip eden haftalarda görüş bozukluğunun olduğu, parlak ışığa tepki vermediği ve engellere takılmadan yürüyemediği tespit edildi. Son literatürlere göre köpeklerde marbofloksasinin aşırı doz uygulanması sonucu gelişen akut körlük ilk kez bildirilmiştir.

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Section: Discussionmentioning

confidence: 99%

Aşırı Doz Marbofloksasin: Bir Köpekte Akut Körlük İçin Olağan Şüpheli

Akin¹,

Karademir²,

Belge³

et al. 2016

Kafkas Univ Vet Fak Derg

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“…Studies of ocular transporters in dogs, humans, and other species have highlighted both the similarities between species, and the differences. For instance, P-gp plays an important role in limiting the availability of topical ophthalmic medications administered to the cornea of rabbits but is less important in dogs [128]. Examples such as this highlight that species differences in drug transporter expression at blood-tissue barriers have practical and important clinical ramifications.…”

Section: The Potential Role Of Transporters At Blood Tissue Barriers ...mentioning

confidence: 99%

Equine Drug Transporters: A Mini-Review and Veterinary Perspective

Rosa

2020

Pharmaceutics

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Xenobiotic transport proteins play an important role in determining drug disposition and pharmacokinetics. Our understanding of the role of these important proteins in humans and pre-clinical animal species has increased substantially over the past few decades, and has had an important impact on human medicine; however, veterinary medicine has not benefitted from the same quantity of research into drug transporters in species of veterinary interest. Differences in transporter expression cause difficulties in extrapolation of drug pharmacokinetic parameters between species, and lack of knowledge of species-specific transporter distribution and function can lead to drug–drug interactions and adverse effects. Horses are one species in which little is known about drug transport and transporter protein expression. The purpose of this mini-review is to stimulate interest in equine drug transport proteins and comparative transporter physiology.

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Pharmacokinetic aspects of retinal drug delivery

Amo

Rimpelä

Heikkinen

et al. 2017

Progress in Retinal and Eye Research

510

533

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Drug delivery to the posterior eye segment is an important challenge in ophthalmology, because many diseases affect the retina and choroid leading to impaired vision or blindness. Currently, intravitreal injections are the method of choice to administer drugs to the retina, but this approach is applicable only in selected cases (e.g. anti-VEGF antibodies and soluble receptors). There are two basic approaches that can be adopted to improve retinal drug delivery: prolonged and/or retina targeted delivery of intravitreal drugs and use of other routes of drug administration, such as periocular, suprachoroidal, sub-retinal, systemic, or topical. Properties of the administration route, drug and delivery system determine the efficacy and safety of these approaches. Pharmacokinetic and pharmacodynamic factors determine the required dosing rates and doses that are needed for drug action. In addition, tolerability factors limit the use of many materials in ocular drug delivery. This review article provides a critical discussion of retinal drug delivery, particularly from the pharmacokinetic point of view. This article does not include an extensive review of drug delivery technologies, because they have already been reviewed several times recently. Instead, we aim to provide a systematic and quantitative view on the pharmacokinetic factors in drug delivery to the posterior eye segment. This review is based on the literature and unpublished data from the authors' laboratory.

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ABC Transporters in the Eyes of Dogs and Implications in Drug Therapy

Cited by 3 publications

References 27 publications

Aşırı Doz Marbofloksasin: Bir Köpekte Akut Körlük İçin Olağan Şüpheli

Aşırı Doz Marbofloksasin: Bir Köpekte Akut Körlük İçin Olağan Şüpheli

Equine Drug Transporters: A Mini-Review and Veterinary Perspective

Pharmacokinetic aspects of retinal drug delivery

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