ABCB1 in dermatology: roles in skin diseases and their treatment

Abstract

Adenosine triphosphate–binding cassette subfamily B member 1 (ABCB1), also known as permeability glycoprotein, multidrug-resistant protein 1, or cluster of differentiation 243 (CD243), is a crucial protein for purging foreign substances from cells. The functions of ABCB1 have been investigated extensively for their roles in cancer, stem cells, and drug resistance. Abundant pharmacogenetic studies have been conducted on ABCB1 and its association with treatment responsiveness to various agents, particularly chemotherapeutic and immunomodulatory agents. However, its functions in the skin and implications on dermatotherapeutics are far less reported. In this article, we reviewed the roles of ABCB1 in dermatology. ABCB1 is expressed in the skin and its appendages during drug delivery and transport. It is associated with treatment responsiveness to various agents, including topical steroids, methotrexate, cyclosporine, azathioprine, antihistamines, antifungal agents, colchicine, tacrolimus, ivermectin, tetracycline, retinoid acids, and biologic agents. Moreover, genetic variation in ABCB1 is associated with the pathogenesis of several dermatoses, including psoriasis, atopic dermatitis, melanoma, bullous pemphigoid, Behçet disease, and lichen planus. Further investigation is warranted to elucidate the roles of ABCB1 in dermatology and the possibility of enhancing therapeutic efficacy through ABCB1 manipulation.

Antifungal Efficacy of Gallic Acid Extracted From Pomegranate Peel Against Trichophyton rubrum: In Vitro Case Study

“…It has been reported that the upregulation of ABCB1 can reduce the drug resistance of bacteria. 28 Our results also suggest that the expression of ABCB1 was significantly increased after the application of GA, suggesting that GA in pomegranate peel extract can reduce the resistance of T rubrum and increase its sensitivity. MEP4 and SUB1 are key enzymes involved in ergosterol biosynthesis in T rubrum.…”

Novel Epoxides of Soloxolone Methyl: An Effect of the Formation of Oxirane Ring and Stereoisomerism on Cytotoxic Profile, Anti-Metastatic and Anti-Inflammatory Activities In Vitro and In Vivo

“…Considering the key role of ATP-binding cassette (ABC) transporters in the efflux of xenobiotic molecules from tumor cells [ 32 ], our attention further turned to the study of the probable direct interaction of SM epoxides and SM with P-glycoprotein (ABCB1), MRP1 (ABCC1) and MXR1 (ABCG2), ABC transporters, which play important functions in the regulation of drug resistance and high malignancy of melanoma [ 33 , 34 , 35 ]. Performed molecular docking studies demonstrated that all evaluated triterpenoids could properly fit into the transmembrane domain of the listed transporters with low binding energies, forming hydrogen bonds with key amino acid residues crucial for the pump activity of these proteins ( Figure 2 D): In the case of P-glycoprotein, SM and αO-SM formed a hydrogen bond with Tyr307, which is involved in regulating the ATP hydrolytic activity of the protein [ 36 ] and is a major interaction partner of the novel benzophenone sulfonamide-based inhibitor of P-glycoprotein [ 37 ].…”

Screening Biomarkers for Systemic Lupus Erythematosus Based on Machine Learning and Exploring Their Expression Correlations With the Ratios of Various Immune Cells

“…Furthermore, we confirmed the expression of ABCB1 in the Chinese population using our own cohort. ABCB1, also known as P-glycoprotein (P-GP), is a multidrug resistance protein mainly expressing in barrier organs such as brain, liver, kidney, and skin (29)(30)(31)(32). Recently, ABCB1 has been reported being expressed in a variety of immune cells, such as monocytes, antigen presenting dendritic cells, T cells and B cells, and is involved in the efflux of inflammatory molecules (33).…”