Arcanobacterium haemolyticum is a gram-positive bacillus that is most commonly implicated in pharyngitis and infections of the skin and soft tissue. Systemic and deep-seated infections caused by this organism are rarely reported in the litera ture.Recently, we encountered two cases of invasive infections caused by A. haemolyticum. We describe two cases, one with vertebral osteomyelitis with an epidural abscess and the other with a buttock abscess with bacteremia.