Abdelazim and Sakiyeva endocrinopathy associated with polycystic ovary syndrome: Case reports

Introduction: A genetic variation at the level of aromatase enzyme and/or androgen receptors was suggested in polycystic ovary syndrome (PCOS).Aim of the study: To determine the androgens elevated and diagnostic for PCOS. Material and methods: A total of 120 PCOS women were compared to non-PCOS controls in this study. The studied women were evaluated thoroughly, including: day 2-3 hormonal profile and any hormonal change confirmed by two laboratory results eight weeks apart. Collected data were analysed to determine the androgens elevated and diagnostic for PCOS.Results: The luteinising hormone (LH) and LH/follicle stimulating hormone (FSH) ratio were significantly high in the studied PCOS group compared to controls (p = 0.02 and 0.01, respectively). In addition, total and free testosterone and androstenedione were significantly high in the studied PCOS group compared to controls (p = 0.001, 0.003, and 0.02, respectively).The studied PCOS group had higher relative risk (RR) and odds ratio (OR) of elevated total testosterone (2.4 and 5.7, respectively), elevated free testosterone (2.9 and 4.9, respectively), and elevated androstenedione (3.0 and 4.8, respectively), compared to controls.Conclusions: Testosterone (both total and free testosterone) and androstenedione were the main elevated androgens and were diagnostic for excess ovarian androgens in the studied PCOS women, whereas dehydroepiandrosterone (DHEA) was not elevated and/or diagnostic for excess ovarian androgens in the studied PCOS women.

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“…PCOS is a multifactorial disorder, involving interactions between certain genes, and pituitary and hypothalamic dysfunction [2,4].…”

Section: Introductionmentioning

confidence: 99%

Elevated and diagnostic androgens of polycystic ovary syndrome

Abdelazim

Alanwar

Abu-Faza

et al. 2020

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“…The elevated thyrotropin-releasing hormone (TRH) in hypothyroidism acts as dopamine antagonist with subsequent hyperprolactinemia [ 9 ]. Abdelazim and Kanshaiym recommended screening of PCOS women for the hypothyroidism, and hyperprolactinemia because the undiagnosed hypothyroidism, and hyperprolactinemia can aggravate the PCOS symptoms [ 10 ]. Therefore, this study designed to determine whether the IR, hypothyroidism, and hyperprolactinemia are common endocrine disorders associated with the PCOS.…”

Section: Introductionmentioning

confidence: 99%

Common endocrine disorders associated with the polycystic ovary syndrome

Abdelazim

Karimova²,

Farghali

2020

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“…According to the ESHRE/ASRM recommendation, causes of hyperandrogenism such as Cushing`s syndrome, late-onset congenital adrenal hyperplasia, and androgen-secreting tumours were excluded before diagnosing PCOS [14][15][16].…”

Section: Methodsmentioning

confidence: 99%

Sildenafil citrate as an adjuvant to clomiphene citrate for ovulation induction in polycystic ovary syndrome: crossover randomized controlled trial

Mohammed¹,

Abbas²,

Abdelazim³

et al. 2022

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Introduction: To evaluate sildenafil citrate as an adjuvant to clomiphene citrate (CC) for ovulation induction (OI) in women with polycystic ovary syndrome (PCOS).Material and methods: A total of 595 infertile PCOS women were randomly assigned into either a clomiphene/sildenafil (C/S) group or a CC group. Transvaginal (TVS)-Doppler studies were done for participants when the dominant follicle reach 16 mm, to measure the resistance index, pulsatility index, and maximum velocity of sub-endometrial, uterine, and ovarian vessels. Participants were examined using TVS on the 21st day of the cycle to detect ovulation or, after a positive pregnancy test, for documentation of pregnancy. Participants with negative pregnancy tests were given 2 months' rest without OI, followed by crossover of OI medication between the 2 studied groups. The crossover results were assessed by TVS, TVS-Doppler, and pregnancy test.Results: The endometrial thickness was significantly higher among the C/S than the CC group during the first 3 months (9.6 ± 1.2 vs. 8.7 ± 1.0 mm, respectively, p = 0.003) and after crossover of OI (9.1 ± 1.3 vs. 8.2 ± 1.0 mm, respectively, p = 0.007).The chemical and clinical pregnancy rates were significantly higher among the C/S compared to the CC group (39.8% and 36.6% vs. 25% and 18.98%, respectively) (p = 0.01 and 0.001, respectively) during the first 3 months and after crossover of OI (36.6% and 33.1% vs. 23.8% and 20.6%, respectively) (p = 0.02 and 0.01, respectively).Conclusions: SC as an adjuvant to CC for OI in PCOS women increases the chemical and clinical pregnancy rates. It also improves the endometrial thickness and ovulation rate through improved endometrial and ovarian Doppler indices.

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Abdelazim and Sakiyeva endocrinopathy associated with polycystic ovary syndrome: Case reports

Cited by 9 publications

References 7 publications

Elevated and diagnostic androgens of polycystic ovary syndrome

Elevated and diagnostic androgens of polycystic ovary syndrome

Common endocrine disorders associated with the polycystic ovary syndrome

Sildenafil citrate as an adjuvant to clomiphene citrate for ovulation induction in polycystic ovary syndrome: crossover randomized controlled trial

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