Abdominal Adipose Tissue was Associated with Glomerular Hyperfiltration among Non- Diabetic and Normotensive Adults with a Normal Body Mass Index

Abstract

Glomerular hyperfiltration is recognized as an early marker of progressive kidney dysfunction in the obese population. This study aimed to identify the relationship between glomerular hyperfiltration and body fat distribution measured by computed tomography (CT) in healthy Korean adults. The study population included individuals aged 20-64 years who went a routine health check-up including an abdominal CT scan. We selected 4,378 individuals without diabetes and hypertension. Glomerular filtration rate was estimated using the CKD-EPI equation, and glomerular hyperfiltration was defined as the highest quintile of glomerular filtration rate. Abdominal adipose tissue areas were measured at the level of the umbilicus using a 16-detector CT scanner, and the cross-sectional area was calculated using Rapidia 2.8 CT software. The prevalence of glomerular hyperfiltration increased significantly according to the subcutaneous adipose tissue area in men (OR = 1.74 (1.16-2.61), P for trend 0.016, for the comparisons of lowest vs. highest quartile) and visceral adipose tissue area in women (OR = 2.34 (1.46-3.75), P for trend < 0.001) in multivariate analysis. After stratification by body mass index (normal < 23 kg/m 2 , overweight 23 kg/m 2 ), male subjects with greater subcutaneous adipose tissue, even those in the normal BMI group, had a higher prevalence of glomerular hyperfiltration (OR = 2.11 (1.17-3.80), P for trend = 0.009). Among women, the significance of visceral adipose tissue area on glomerular hyperfiltration resulted from the normal BMI group (OR = 2.14 (1.31-3.49), P for trend = 0.002). After menopause, the odds ratio of the association of glomerular hyperfiltration with subcutaneous abdominal adipose tissue increased (OR = 2.96 (1.21-7.25), P for trend = 0.013). Subcutaneous adipose tissue areas and visceral adipose tissue areas are positively associated with glomerular hyperfiltration in healthy Korean adult men and women, PLOS ONE |

Effects of age and sex on the relationship between body fat area and kidney events in patients with chronic kidney disease

“…In our study, not only was SFA identified as a risk factor with a statistically significant difference, but VFA also tended to increase kidney events. There are also reports of an association between SFA and worse glomerular hyperfiltration in healthy males 15 . Our results support those of a study that reported an association between body fat and kidney events.…”

“…There are also reports of an association between SFA and worse glomerular hyperfiltration in healthy males. 15 Our results support those of a study that reported an association between body fat and kidney events. Based on these results, we considered that high body fat area in males aged <75 years with CKD could be a risk factor for kidney events.…”

<p>Individual and Combined Components of Metabolic Syndrome with Chronic Kidney Disease in Individuals with Hypertension and/or Diabetes Mellitus Accompanied by Primary Health Care</p>

“…GFR. Lee et al 24 demonstrated in adult and postmenopausal men and women that subcutaneous adipose tissue showed increased association with glomerular hyperfiltration. This association was explained by the increase in leptin levels that are released by subcutaneous adipose tissue.…”

Risks of Muscle Atrophy in Patients with Malignant Lymphoma after Autologous Stem Cell Transplantation

“…VFA and SFA were measured as previously described 19) . Briefly, the VFA and SFA were measured by diagnostic CT scanning at the umbilical crossing line 19 ) . CT scan images had already been performed for the assessment of ML.…”