Abdominal Aortitis after Use of Granulocyte Colony-Stimulating Factor

Adiga, Giridhar U.; El-Kadi, D. A.; Malik, Sabrina; Fitzpatrick, Jill D.; Madajewicz, Stefan

doi:10.2165/11530790-000000000-00000

Cited by 36 publications

(17 citation statements)

References 9 publications

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“…To gather data related to G-CSF-induced aortitis, we searched the PubMed database using the term "G-CSF AND aortitis" (6). Seventeen case reports were found between 2004 and 2019 (5,(7)(8)(9)(10)(11). In addition to the previous reports, a total of 21 cases were summarized, including the present case and other cases from our department (Table).…”

Section: Discussionmentioning

confidence: 99%

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Migratory Aortitis Associated with Granulocyte-colony-stimulating Factor

et al. 2020

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We herein report a case of migratory aortitis after the administration of granulocyte-colony-stimulating factor (G-CSF) to a 65-year-old woman with a history of pancreatic cancer. She was being administered pegfilgrastim and developed aortitis around the aortic arch. Although it resolved within two weeks, she again developed aortitis around the descending aorta, presenting as migratory aortitis, after pegfilgrastim was resumed. We further experienced three additional cases of G-CSF-induced aortitis that also showed spontaneous resolution, suggesting no or short-term use of immunosuppression. Aortitis due to G-CSF can present as migratory aortitis, since aortitis can quickly resolve and inflammation can recur at a different location.

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Section: Discussionmentioning

confidence: 99%

“…Recently, the development of aortitis following the use of granulocyte-colony-stimulating factor (G-CSF) has been recognized (5). We experienced four cases of aortitis associated with the use of G-CSF.…”

Section: Introductionmentioning

confidence: 99%

Migratory Aortitis Associated with Granulocyte-colony-stimulating Factor

et al. 2020

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“…Generally, drug-induced vasculitis develops within seven to 21 days after a drug regimen is started (1). Drugs that have been implicated in large vessel vasculitis include penicillin, aminopenicillins, sulfonamide, allopurinol, thiazides, quinolones, hydantoins, propylthiouracil (1) and G-CSF (2). Of the many antineoplastic chemotherapy agents, gemcitabine and platinum-based therapies are most frequently associated with vascular complications.…”

Section: Discussionmentioning

confidence: 99%

Periaortitis Associated with Anti-neutrophil Cytoplasmic Antibodies Induced by Bevacizumab Combination Therapy

et al. 2013

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Drug-induced vessel vasculitis is a rare complication of chemotherapy. In particular, few reports have investigated drug-induced large vessel vasculitis. We herein report the case of a 57-year-old woman with advanced lung adenocarcinoma who developed perinuclear anti-neutrophil cytoplastic antibodies (p-ANCA)-positive periaortitis induced by bevacizumab combination chemotherapy. With the increasing use of combination therapy with bevacizumab, the incidence of vascular complications will potentially increase. A noninfectious fever occurring during chemotherapy might be a sign of vasculitis; therefore, we must ensure that possible periaortitis is not overlooked.

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“…(16) In addition, a case in which carotidynia was histologically confirmed showed lymphocytic inflammation with fibrosis, although the recruitment of neutrophils was also observed. (15) In our patient, blood neutrophil count was 19,500/µL at the onset of carotidynia.…”

Section: B 3amentioning

confidence: 99%