Abdominal fat is associated with a greater brain reward response to high‐calorie food cues in hispanic women

Luo, Shan; Romero, Alessandra de Cássia; Adam, Tanja C.; Hu, Houchun H.; Monterosso, John; Page, Kathleen A.

doi:10.1002/oby.20344

Cited by 40 publications

(37 citation statements)

References 40 publications

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“…These data therefore suggest that fat mass may predict food reward (particularly food wanting) independently of fat-free mass. These findings are consistent with recent observations that fat mass and fat-free mass operated differentially in the control of appetite, with separate roles for fat-free mass in satiation [29] and hunger [19, 30] and fat mass in hedonic eating behaviour traits [31] and neural activation to high energy foods[32]. However, these findings are so far limited to obese individuals and need to be confirmed in a range of different populations, that is, lean versus obese and active versus inactive.…”

Section: Discussionsupporting

confidence: 92%

Fasting Leptin Is a Metabolic Determinant of Food Reward in Overweight and Obese Individuals during Chronic Aerobic Exercise Training

Hopkins

Gibbons

Caudwell

et al. 2014

International Journal of Endocrinology

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Changes in food reward have been implicated in exercise-induced compensatory eating behaviour. However, the underlying mechanisms of food reward, and the physiological correlates of exercise-induced changes in food reward, are unknown. Methods. Forty-six overweight and obese individuals completed 12 weeks of aerobic exercise. Body composition, food intake, and fasting metabolic-related hormones were measured at baseline, week six, and postintervention. On separate days, the reward value of high-and-low-fat food (explicit liking and implicit wanting) was also assessed at baseline, week six, and postintervention. Results. Following the intervention, FM, FFM, and VO2peak improved significantly, while fasting leptin decreased. However, food intake or reward did not change significantly. Cross-sectional analyses indicated that FM (P = 0.022) and FFM (P = 0.046) were associated with explicit liking for high-fat food, but implicit wanting was associated with FM only (P = 0.005). Fasting leptin was associated with liking (P = 0.023) and wanting (P = 0.021) for high-fat food. Furthermore, a greater exercise-induced decline in fasting leptin was associated with increased liking (P = 0.018). Conclusion. These data indicate that food reward has a number of physiological correlates. In particular, fasting leptin appears to play an active role in mediating food reward during exercise-induced weight loss.

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Section: Discussionsupporting

confidence: 92%

Fasting Leptin Is a Metabolic Determinant of Food Reward in Overweight and Obese Individuals during Chronic Aerobic Exercise Training

Hopkins

Gibbons

Caudwell

et al. 2014

International Journal of Endocrinology

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“…The associations found between visceral adiposity levels and functional connectivity changes within mIns networks concur with previous neuroimaging studies showing anatomical and functional alterations in this region in relation to visceral adiposity (8,11,12). Furthermore, they support Craig's models of insular cortex function (7,13), which emphasizes the role of this region in processing information about the body's homeostatic state.…”

Section: Discussionsupporting

confidence: 89%

“…Neuroimaging studies have consistently found associations between visceral adiposity levels and both structural alterations (8)(9)(10) and increased activations to caloric foods (11,12) in the anterior and mid-posterior insular regions. Posterior sections of the insula are primarily involved in processing interoceptive signals (7,13), therefore changing its activation in relation to the homeostatic states of hunger and satiety (14,15).…”

Section: Introductionmentioning

confidence: 99%

“…Likewise, we also investigated whether the putative association between visceral adiposity-and insulae functional networks was related to heightened food craving. We hypothesized that greater levels of body visceral adiposity will modulate the connectivity between the mIns and interoceptive processing regions, such as the hypothalamus (17,18), and between the rIns and saliency processing regions, such as the amygdala, dorsal anterior cingulate cortex, and orbital-opercular cortices (11,12,16). Moreover, we expected that such associations between functional connectivity patterns of the insula and visceral adiposity was also related with increased food craving (11,12,18).…”

Section: Introductionmentioning

confidence: 99%

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Visceral adiposity and insular networks: associations with food craving

et al. 2018

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“…Such foods are powerful drivers of obesity that contribute to, maintain, and promote overeating (42–46). This is due, in part, to the highly reinforcing properties of high-fat foods.…”

Section: Discussionmentioning

confidence: 99%

Regulation of motivation for food by neuromedin U in the paraventricular nucleus and the dorsal raphe nucleus

2016

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BACKGROUNDMotivation for high-fat food is thought to contribute to excess caloric intake in obese individuals. A novel regulator of motivation for food may be Neuromedin U (NMU), a highly-conserved neuropeptide which influences food intake. Although these effects of NMU have primarily been attributed to signaling in the paraventricular nucleus of the hypothalamus (PVN), NMU has also been found in other brain regions involved in both feeding behavior and motivation. We investigate the effects of NMU on motivation for food and food intake, and identify the brain regions mediating these effects.METHODSThe motivational state for a particular reinforcer (e.g., high-fat food) can be assessed using a progressive ratio schedule of reinforcement under which an increasing number of lever presses are required to obtain subsequent reinforcers. Here, we have employed a progressive ratio operant responding paradigm in combination with an assessment of cumulative food intake to evaluate the effects of NMU administration in rats, and identify the brain regions mediating these effects.RESULTSWe found that peripheral administration of NMU decreases operant responding for high-fat food in rats. Evaluation of Fos-like immunoreactivity in response to peripheral NMU indicated the PVN and dorsal raphe nucleus (DRN) as sites of action for NMU. NMU infusion into either region mimics the effects of peripheral NMU on food intake and operant responding for food. NMU-containing projections from the lateral hypothalamus (LH) to the PVN and DRN were identified as an endogenous source of NMU.CONCLUSIONSThese results identify the DRN as a site of action for NMU, demonstrate that the LH provides endogenous NMU to the PVN and DRN, and implicate NMU signaling in the PVN and DRN as a novel regulator of motivation for high-fat foods.

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Abdominal fat is associated with a greater brain reward response to high‐calorie food cues in hispanic women

Cited by 40 publications

References 40 publications

Fasting Leptin Is a Metabolic Determinant of Food Reward in Overweight and Obese Individuals during Chronic Aerobic Exercise Training

Fasting Leptin Is a Metabolic Determinant of Food Reward in Overweight and Obese Individuals during Chronic Aerobic Exercise Training

Visceral adiposity and insular networks: associations with food craving

Regulation of motivation for food by neuromedin U in the paraventricular nucleus and the dorsal raphe nucleus

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