Abdominal Manifestations of Extranodal Lymphoma: Spectrum of Imaging Findings

Lee, Wai-Kit; Lau, Eddie; Duddalwar, Vinay; Stanley, Anthony; Ho, Yvonne Y.

doi:10.2214/ajr.07.3146

Cited by 88 publications

(90 citation statements)

References 17 publications

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“…F-FDG distribution must be confirmed by anatomical imaging modalities, endoscopic studies and biopsies for a definitive diagnosis. Some studies have also reported that structural CT abnormalities and uptake intensities can improve the reliability of 18 F-FDG PET-CT for the differentiation of lymphomatous infiltration from physiological tracer activity, but the uptake pattern has not been found to be a reliable marker (3,4,8,(19)(20)(21)(22). The Waldeyer's ring and lungs are also sites that have relatively high false positive results due to infectious or inflammatory reasons (23).…”

Section: Discussionmentioning

confidence: 99%

Fluorine-18 fluorodeoxyglucose PET-CT for extranodal staging of non-Hodgkin and Hodgkin lymphoma

Ömür

Baran

Oral³

et al. 2014

Diagn Interv Radiol

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NUCLEAR MEDICINE AND MOLECULAR IMAGINGF-FDG PET-CT imaging, following a diagnostic contrast-enhanced CT (CE-CT) performed within the last month, were included in our study. A total of 129 PET-CT images, and all radiologic, clinical, and pathological records of these patients were retrospectively reviewed. RESULTSIn total, 137 hypermetabolic extranodal infiltration sites were detected by 18 F-FDG PET-CT in 62 of 110 patients. There were no positive findings by CE-CT that reflected organ involvement in 40 of 137 18 F-FDG-positive sites. The κ statistics revealed fair agreement between PET-CT and CE-CT for the detection of extranodal involvement (κ=0.60). The organs showing a disagreement between the two modalities were the spleen, bone marrow, bone, and thyroid and prostate glands. In all lesions that were negative at CE-CT, there was a diffuse 18 F-FDG uptake pattern in the PET-CT images. The frequency of extranodal involvement was 51% and 58% in Hodgkin and non-Hodgkin lymphoma patients, respectively. There was a high positive correlation between the maximum standardized uptake values of the highest 18 F-FDG-accumulating lymph nodes and extranodal sites (r=0.67) in patients with nodal and extranodal involvement. CONCLUSION 18 F-FDG PET-CT is a more effective technique than CE-CT for the evaluation of extranodal involvement in Hodgkin and non-Hodgkin lymphoma patients. PET-CT has a significant advantage for the diagnosis of diffusely infiltrating organs without mass lesions or contrast enhancement compared to CE-CT.

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Section: Discussionmentioning

confidence: 99%

Fluorine-18 fluorodeoxyglucose PET-CT for extranodal staging of non-Hodgkin and Hodgkin lymphoma

Ömür

Baran

Oral³

et al. 2014

Diagn Interv Radiol

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“…(13) In these cases, the spleen may demonstrate focal nodules or diffuse enlargement. The nodules are typically hypoattenuating, with reduced contrast material enhancement compared to normal splenic tissue.…”

Section: Discussionmentioning

confidence: 99%

Peritoneal lymphomatosis mimicking peritoneal carcinomatosis: important imaging clues for correct diagnosis

Sia¹,

Kapur²,

Thian³

2013

SMedJ

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Peritoneal lymphomatosis, a rare presentation of lymphoma, can mimic peritoneal carcinomatosis.Computed tomography findings in both conditions include omental caking, as well as peritoneal enhancement, thickening and nodularity. We report three cases of peritoneal lymphomatosis and give an analysis of the salient imaging features that aided in the accurate diagnosis of the condition in each case. Two of the three cases demonstrated elevated serum cancer antigen 125 levels, a marker commonly associated with ovarian carcinoma. It is thus critical to distinguish peritoneal lymphomatosis from carcinomatosis, as the prognosis and management are dramatically different.

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“…The abdominal and pelvic region, including the gastrointestinal tract, mesentery, peritoneum, retroperitoneum, and genitourinary tract, is commonly affected by BL, particularly by its sporadic form (7,8). The ileocecal region, specifically the Peyer's patches, is the most common site involved.…”

Section: Abdominal Involvementmentioning

confidence: 99%

“…Infiltrating masses in the periportal area of the liver or in the perihilar area of the kidney may be observed and cause biliary obstruction or ureteropelvic obstruction, respectively ( Fig. 10) (5,8,10). Testicular and ovarian involvement in BL has been reported.…”

Section: Main Pointsmentioning

confidence: 99%