Abdominal metastases from Merkel cell carcinoma: Prevalence and presentation on CT examination in 111 patients

Girard, Raphaël; Djelouah, Manel; Barat, Maxime; Fornès, Paul; Guégan, Sarah; Dupin, Nicolas; Soyer, Philippe; Hoeffel, Christine

doi:10.1016/j.diii.2021.08.002

Cited by 6 publications

(5 citation statements)

References 35 publications

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“…Pancreatic lesion characterization is also of paramount importance, because the pancreas can be involved by a wide spectrum of conditions, including benign and malignant primary lesions, lesions with intermediate malignant potential, and metastases from distant primaries. [31][32][33][34][35] Although morphological imaging findings can be used to confidently discriminate between several pancreatic entities, researchers have tested the capabilities of radiomics in differentiating between PDAC and other pancreatic conditions, including normal pancreatic parenchyma. 32,36,37 In this regard, one study showed that radiomics has the ability to differentiate PDAC from AIP, with an accuracy of 95.2% compared to 67% by the radiologists.…”

Section: Lesion Characterizationmentioning

confidence: 99%

Imaging of Pancreatic Ductal Adenocarcinoma: An Update on Recent Advances

et al. 2022

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Pancreatic ductal carcinoma (PDAC) is one of the leading causes of cancer-related death worldwide. Computed tomography (CT) remains the primary imaging modality for diagnosis of PDAC. However, CT has limitations for early pancreatic tumor detection and tumor characterization so that it is currently challenged by magnetic resonance imaging. More recently, a particular attention has been given to radiomics for the characterization of pancreatic lesions using extraction and analysis of quantitative imaging features. In addition, radiomics has currently many applications that are developed in conjunction with artificial intelligence (AI) with the aim of better characterizing pancreatic lesions and providing a more precise assessment of tumor burden. This review article sums up recent advances in imaging of PDAC in the field of image/data acquisition, tumor detection, tumor characterization, treatment response evaluation, and preoperative planning. In addition, current applications of radiomics and AI in the field of PDAC are discussed.

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Section: Lesion Characterizationmentioning

confidence: 99%

Imaging of Pancreatic Ductal Adenocarcinoma: An Update on Recent Advances

et al. 2022

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“…Abdominal metastatic disease is described, but rare. Girard et al [ 3 ] identified 27 out of 111 patients with abdominal metastases from MCC to the non-regional lymph nodes, liver, and pancreas. A study that analyzed a cohort of over 200 patients found that the primary site of initial MCC influences the location of metastasis [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

“…A study that analyzed a cohort of over 200 patients found that the primary site of initial MCC influences the location of metastasis [ 10 ]. Gastrointestinal metastases from MCC are particularly rare, and the stomach has been reported as the most common site [ 3 , 11 ]. MCC metastasis causing large bowel obstruction is atypical, and its clinical presentation must be elucidated further to guide future management.…”

Section: Discussionmentioning

confidence: 99%

“…Because of its aggressive nature, about one-third of patients diagnosed with MCC have distant metastatic disease at diagnosis. Common sites of metastatic disease include lymph nodes, skin/body wall, and liver [ 3 , 4 ]. We present a rare case of upper extremity MCC, which metastasized to the intraperitoneal cavity-causing obstruction and ultimate perforation.…”

Section: Introductionmentioning

confidence: 99%

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Large Intestinal Obstruction and Perforation From Metastatic Merkel Cell Carcinoma: A Case Report

Lee,

Roman,

Newman

et al. 2023

Cureus

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Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine neoplasm of the skin that has a high propensity to metastasize. Abdominal metastases of MCC have been described previously though these are typically regional with nodal spread. We report the case of a 60-year-old man with a history of left upper extremity MCC who had resection, radiation therapy, and immunotherapy. He ultimately developed large bowel obstruction from metastatic intraperitoneal implants. A 6 cm mass at the descending colon was biopsied and proven to be metastatic MCC. The tumor eroded through the wall of the colon and perforated, requiring emergent colectomy for septic shock. Herein, we describe the first case of colonic perforation secondary to metastatic MCC. This case illustrates the importance of expedient and multifactorial management of patients with rapidly growing metastatic colonic tumors that are at risk for perforation.

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“…2,3 If MCC is determined in the absence of a known diagnosis or a primary cutaneous lesion, which is estimated to occur in one-third to half of all cases of MCC, pathologic techniques are used to characterize these tumors as MCC of unknown primary (MCCUP). [3][4][5] While MCC is commonly linked with sun exposure, both MCC and its rarer counterpart MCCUP have been attributed to Merkel cell polyomavirus (MCPyV) infection. 3,6 Prior reports of MCC with GI involvement have presented with symptoms ranging from fatigue and unintentional weight loss to GI bleeding.…”

Section: Introductionmentioning

confidence: 99%

An Extraordinary Cause of Colonic Obstruction: Merkel Cell Carcinoma of Unknown Primary

et al. 2023

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Merkel cell carcinoma is an aggressive and rare neuroendocrine skin cancer with documented metastases to the liver, lungs, and, seldom, the gastrointestinal tract. Metastases to the colon are rare but are seen with primary skin lesions or recurrent disease. Presented is a patient with large bowel obstruction secondary to a large hepatic flexure mass. Pathologic workup revealed Merkel cell carcinoma, and a dermatologic evaluation did not identify a primary cutaneous lesion. This is the first reported case of Merkel cell carcinoma of unknown primary presenting as large bowel obstruction.

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Abdominal metastases from Merkel cell carcinoma: Prevalence and presentation on CT examination in 111 patients

Cited by 6 publications

References 35 publications

Imaging of Pancreatic Ductal Adenocarcinoma: An Update on Recent Advances

Imaging of Pancreatic Ductal Adenocarcinoma: An Update on Recent Advances

Large Intestinal Obstruction and Perforation From Metastatic Merkel Cell Carcinoma: A Case Report

An Extraordinary Cause of Colonic Obstruction: Merkel Cell Carcinoma of Unknown Primary

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