Abdominal Ultrasound Findings of Tumor-Forming Hepatic Malignant Lymphoma

Kitahata, Shogo; Hiraoka, Atsushi; Kudo, Masatoshi; Murakami, Taisei; Ochi, Marie; Izumoto, Hirofumi; Ueki, Hidetaro; Kaneto, Miho; Aibiki, Toshihiko; Okudaira, Taeko; Yamago, Hiroka; Miyamoto, Yuji; Iwasaki, Ryuichiro; Tomida, Hideomi; Mori, Kenichiro; Kishida, Masato; Miyata, Hideki; Tsubouchi, Eiji; Hirooka, Masashi; Nakamura, Tomoyuki; Hiasa, Yoichi; Michitaka, Kojiro

doi:10.1159/000480138

Cited by 5 publications

(3 citation statements)

References 29 publications

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“…The tumors also showed penetrating vessels in the arterial phase. It was discovered earlier that multiple vascular channels could often be seen coursing through hepatic malignant lymphoma, including MALT lymphoma, which were referred to as the "vessel penetration sign" [34,35]. Comparisons of the image results of the present case with previously reported extranodal marginal zone lymphoma of MALT findings and typical hepatocellular carcinoma are summarized in Table 3.…”

Section: Discussionsupporting

confidence: 51%

Primary Hepatic Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue in a Patient with Chronic Hepatitis B Virus Infection: Case Report and Summary of the Literature

et al. 2021

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Background: The incidence of extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is low, at 7–8% of all non-Hodgkin lymphoma cases. The most common site of MALT lymphoma occurrence is the stomach. Primary hepatic extranodal marginal zone lymphoma of MALT is classified as a type of non-gastric MALT lymphoma and is considered extremely rare, with no consensus on imaging study findings or treatment due to a limited number of reports. We herein describe a rare case of primary hepatic extranodal marginal zone lymphoma of MALT with underlying hepatitis B infection (HBV) and present useful diagnostic findings of various imaging modalities, including contrast-enhanced ultrasonography (CEUS) with Sonazoid. Case presentation: A 66-year-old woman was diagnosed as being a non-active carrier of HBV at 51 years of age at the time of total hysterectomy and bilateral adnexectomy for uterine cervical cancer. She was admitted to our hospital following the incidental detection of two focal liver lesions on computed tomography. The lesions were considered malignant based on clinical and other radiologic imaging findings. Her CEUS results of hypo-enhancement in the portal and late phases were consistent with those of previously reported cases of hepatic extranodal marginal zone lymphoma of MALT, and histological liver biopsy findings were compatible with the diagnosis. Conclusions: Primary hepatic extranodal marginal zone lymphoma of MALT is a rare condition that can appear in HBV carriers. Characteristic CEUS findings may help in disease diagnosis. Clinicians should bear primary hepatic extranodal marginal zone lymphoma of MALT in mind when encountering patients with focal liver lesions which exhibit image findings different from those of typical hepatocellular carcinoma.

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Section: Discussionsupporting

confidence: 51%

Primary Hepatic Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue in a Patient with Chronic Hepatitis B Virus Infection: Case Report and Summary of the Literature

et al. 2021

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“…However, the pathogenesis of the diseases has not been elucidated. PHC and TC are often in advanced stages when there are clear symptoms and the patients seek medical assistance due to no symptoms in the early stages, which increases the difficulty of clinical intervention ( 11 , 12 ). Therefore, early diagnosis of PHC and TC, as well as timely effective treatments, is of great significance to patients' survival and prognosis.…”

Section: Discussionmentioning

confidence: 99%

Value of ultrasonography in the diagnosis of primary hepatic carcinoma and thyroid carcinoma

2018

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The present study explored the value of ultrasonography in the diagnosis of primary hepatic carcinoma (PHC) and thyroid carcinoma (TC) by assessing their sonographic features. A total of 426 patients diagnosed with liver space-occupying lesions by ultrasonic examination admitted to Liaocheng People's Hospital from March 2014 to October 2017 were enrolled in this study. These patients were divided into two groups: A total of 226 patients with 237 foci in the PHC group and 200 patients with 216 foci in the benign liver lesion group. During the same period, 367 patients diagnosed with thyroid nodules (382 nodules) by ultrasonic examination were also enrolled in this study. These patients were divided into further two groups: A total of 193 patients with 203 nodules in the TC group and 174 patients with 179 nodules in the benign thyroid nodule group. Two-dimensional and color Doppler ultrasonography were performed on all the patients in the four groups. Differences in the sonographic features such as focus morphology, focus size, internal echo, halo and blood flow distribution were statistically significant between patients in the PHC and the benign liver lesion group (p<0.001). Differences in the sonographic features such as nodule boundary, nodule size, internal echo, microcalcification, lymph node status and blood flow were statistically significant between patients in the TC and the benign thyroid nodule group (p<0.01). PHC can be differentiated from benign liver lesions by evaluation of focus morphology, focus size, internal echo, halo, and blood flow. TC can be differentiated from benign thyroid nodules by evaluation of nodule boundary, nodule size, internal echo, microcalcification, lymph node status, and blood flow. Ultrasonic diagnosis of PHC and TC is not only accurate, but also convenient, fast, cost-efficient and non-invasive. Thus, application of ultrasonography in the diagnosis of PHC and TC should be expanded for the benefits of patients.

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“…The diffuse pattern is usually seen in secondary involvement of the organ or in post-transplant lymphoproliferative disease. CEUS typically reveals APHE and early and punched washout [ 202 , 203 , 204 ]. Similar CECT and CEMRI features have been described as well [ 205 , 206 , 207 , 208 , 209 , 210 , 211 ].…”

Section: Malignant Focal Liver Lesionsmentioning

confidence: 99%

Incidental Findings in Pediatric Patients: How to Manage Liver Incidentaloma in Pediatric Patients

Čekuolis

Schreiber-Dietrich

Augustinienė

et al. 2023

Cancers

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The World Federation for Ultrasound in Medicine and Biology (WFUMB) is addressing the issue of incidental findings (IFs) with a series of publications entitled “Incidental imaging findings—the role of ultrasound”. IFs in the liver of newborns and children are rare and much less commonly encountered than in adults; as a result, they are relatively much more frequently malignant and life-threatening, even when they are of benign histology. Conventional B-mode ultrasound is the well-established first line imaging modality for the assessment of liver pathology in pediatric patients. US technological advances, resulting in image quality improvement, contrast-enhanced ultrasound (CEUS), liver elastography and quantification tools for steatosis have expanded the use of ultrasound technology in daily practice. The following overview is intended to illustrate incidentally detected liver pathology covering all pediatric ages. It aims to aid the examiner in establishing the final diagnosis. Management of incidentally detected focal liver lesions (FLL) needs to take into account the diagnostic accuracy of each imaging modality, the patient’s safety issues (including ionizing radiation and nephrotoxic contrast agents), the delay in diagnosis, the psychological burden on the patient and the cost for the healthcare system. Moreover, this paper should help the pediatric clinician and ultrasound practitioner to decide which pathologies need no further investigation, which ones require interval imaging and which cases require further and immediate diagnostic procedures.

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Abdominal Ultrasound Findings of Tumor-Forming Hepatic Malignant Lymphoma

Cited by 5 publications

References 29 publications

Primary Hepatic Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue in a Patient with Chronic Hepatitis B Virus Infection: Case Report and Summary of the Literature

Primary Hepatic Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue in a Patient with Chronic Hepatitis B Virus Infection: Case Report and Summary of the Literature

Value of ultrasonography in the diagnosis of primary hepatic carcinoma and thyroid carcinoma

Incidental Findings in Pediatric Patients: How to Manage Liver Incidentaloma in Pediatric Patients

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