Aberrant Activation-Induced Cytidine Deaminase Gene Expression Links BCR/ABL1-Negative Classical Myeloproliferative Neoplasms

Dermenci, Hasan; Aday, Aynur Dağlar; Akadam-Teker, Başak; Hancer, Veysel Sabri; Gelmez, Metin Yusuf; Nalçacı, Meliha; Yavuz, Akif Selim

doi:10.4274/haseki.galenos.2022.8133

Cited by 1 publication

(2 citation statements)

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“…Previous studies on myelodysplastic syndrome and myeloproliferative neoplasms have found a strong association between AID overexpression and these malignancies (14,17)…”

Section: Discussionmentioning

confidence: 99%

“…) reported the kinase activity of BCR-ABL to upregulate AID expression and increase genetic instability, thus contributing to the progression of CML to BC and the leukemogenesis of BCR-ABL+ B-ALL. Assuming AID to be an oncogene that initiates tumorigenesis, a therapy targeting AID has been suggested for possibly suppressing processes such as cell proliferation and migration (17).…”

Section: Discussionmentioning

confidence: 99%

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Activation-Induced Cytidine Deaminase Expression in Patients with Chronic Myeloid Leukemia

Oğuz¹,

Aday²,

Yavuz³

2022

experimed

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Objective: The findings on chronic myeloid leukemia (CML) patients suggest that clonal tumoral cells tend to have additional mutations besides the formation of the BCR-ABL fusion gene. Previous studies have demonstrated abnormal activation-induced cytidine deaminase (AID) expression in various types of cancer, showing AID transcript levels to be elevated in the CML blast phase. The study aimed to investigate the AID gene expression levels in CML and to investigate the etiopathogenic role of AID, which is not yet fully understood. Materials and Methods:This study analyzed the AID transcript levels of 80 CML patients and 50 controls using real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR). Results:The study found the AID transcript levels to be significantly elevated (p < 0.001) in the CML patients compared to the control group, with no significance in AID transcript levels with regard to the patients' age, gender, clinical characteristics, or laboratory findings. No correlation was found between the AID and BCR-ABL transcript levels, while a positive correlation was present between AID transcript levels and presence of polymorphonuclear leukocytes (PMNL; r = 0.320, p = 0.021). No significant relationship occurred in AID transcription levels with the tyrosine-kinase-inhibitor (TKI) resistant mutation profile or cytogenetic response during TKI therapy. Conclusion:This study found AID expression levels to be significantly elevated in CML patients and AID to be able to contribute to the etiopathogenesis of CML

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“…Previous studies on myelodysplastic syndrome and myeloproliferative neoplasms have found a strong association between AID overexpression and these malignancies (14,17)…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%