Aberrant DNA methylation patterns in diabetic nephropathy

Maghbooli, Zhila; Larijani, Bagher; Emamgholipour, Solaleh; Amini, Manochehr; Keshtkar, Abbasali; Pasalar, Parvin

doi:10.1186/2251-6581-13-69

Cited by 48 publications

(37 citation statements)

References 55 publications

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“…The inclusion and exclusion criteria, retinopathy and nephropathy diagnosis criteria of the study population have been described previously [21–23]. …”

Section: Methodsmentioning

confidence: 99%

The association between bone turnover markers and microvascular complications of type 2 diabetes

Maghbooli

Shabani

Gorgani‐Firuzjaee

et al. 2016

J Diabetes Metab Disord

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BackgroundGlobal epidemic of diabetes is a serious health care concern because of its complications and consequently reduced life expectancy and increased morbidity. However, the bone turnover and thus bone health may be affected or even compromised by diabetes and its complications. The aim of this study was to assess whether bone turnover markers are associated with diabetes micro-vascular complications.MethodsA total of 204 type 2 diabetes patients (104 patients with diabetic micro-vascular complications (retinopathy and/or nephropathy) as a case group and 100 patients without retinopathy and/or nephropathy) as a control group were recruited in this case–control study. The biochemical and metabolic parameters and bone turnover markers were assessed in all patients.ResultsOur findings showed serum levels of osteocalcin (OC) (p = 0.0001) and, carboxy-terminal collagen crosslinks (CTX) (p = 0.006) were higher in diabetic patients with both diabetic retinopathy and nephropathy compared with control group. However, there was no significant difference in serum levels of procollagen I aminoterminal propeptide (P1NP) between diabetic patients with diabetic retinopathy (DR) and/or diabetic nephropathy (DN) compared with control.In diabetes patients with complications, there were significant negative correlation between OC and CTX with estimated-glomerular filtration rate (e-GFR) and also positive correlation between each bone marker (OC and CTX) and PTH levels (p = 0.0001) and BUN (p = 0.0001).In a general linear model, after adjusting for age, sex and BMI, and microvascular complications, there was not any significant association between three bone turnover markers and metabolic markers including fasting glucose, insulin, and lipid profile. Among kidney markers, there were significant positive associations between serum levels of CTX and OC with BUN (p < 0.05) as well as PTH (p < 0.0001).ConclusionsOur data suggest the possible role of PTH and BUN levels in modulating bone turnover markers in diabetic patients.

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“…The inclusion and exclusion criteria, retinopathy and nephropathy diagnosis criteria of the study population have been described previously [21–23]. …”

Section: Methodsmentioning

confidence: 99%

The association between bone turnover markers and microvascular complications of type 2 diabetes

Maghbooli

Shabani

Gorgani‐Firuzjaee

et al. 2016

J Diabetes Metab Disord

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“…In a separate study, DNA methylation profiling with the Infinium 27K bead array from samples of whole blood was used to identify 19 prospective CpG sites associated with risk of DN in T1DM compared to those without nephropathy . Additional studies using various DNA methylation assays and DNA collected from peripheral blood samples or saliva identified specific DNA methylation profiles for diabetic patients with and without nephropathy . Most of these studies proposed using DNA methylation profiles as biomarkers to help predict disease status and progression and did not report associated gene expression data.…”

Section: Diabetic Nephropathy and Dna Methylationmentioning

confidence: 99%

DNA methylation and its role in the pathogenesis of diabetes

2017

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Although the factors responsible for the recent increase in the prevalence of diabetes worldwide are not entirely known, the morbidity associated with this disease results in substantial health and economic burden on society. Epigenetic modifications, including DNA methylation have been identified as one mechanism by which the environment interacts with the genome and there is evidence that alterations in DNA methylation may contribute to the increased prevalence of both Type 1 and Type 2 diabetes. This review provides a summary of DNA methylation and its role in gene regulation, and includes descriptions of various techniques to measure site-specific and genome wide DNA methylation changes. In addition, we review current literature highlighting the complex relationship between DNA methylation, gene expression, and the development of diabetes and related complications. In studies where both DNA methylation and gene expression changes were reported, DNA methylation status had a strong inverse correlation with gene expression, suggesting that this interaction may be a potential future therapeutic target. We highlight the emerging use of genome wide DNA methylation profiles as a biomarker to predict patients at risk of developing diabetes or specific complications of diabetes. Developing a predictive model that incorporates both genetic information and DNA methylation changes may be an effective diagnostic approach for all types of diabetes and could lead to additional innovative therapies.

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“…In animal models, epigenetic silencing due to increased promoter DNA methylation has been linked to islet dysfunction and development of diabetes [69,70]. In a casecontrolled study of 168 patients with type 2 DM, the global DNA methylation status was shown to be associated with DR. Additionally, the DNA methylation status exhibited a strong correlation with the progression of DR [71,72]. Apart from the increased activity of Dnmts in the retina and its capillary cells [73], histone-modifying machinery is also affected in diabetes.…”

Section: The Role Of Epigenetics In the Pathogenesis Of Diabetic Retimentioning

confidence: 99%

Oxidative Stress Biomarkers for Diabetic Retinopathy and Medical Management Affecting Oxidative Stress

Cilenšek¹,

Ramuš²,

Petrovič³

et al. 2016

Role of Biomarkers in Medicine

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Changes in dietary habits and lifestyles associated with rapid economic growth have dramatically increased the incidence of diabetes and related vascular complications. Diabetic retinopathy (DR), a microvascular complication of diabetes, is associated with both environmental and genetic factors. Several metabolic abnormalities are implicated in its pathogenesis; however, the exact mechanism remains to be determined. Among them, oxidative stress is expected to play an important role.Environmental, genetic, and epigenetic factors affecting the oxidative stress responsible for DR are reviewed in this paper. The knowledge about genetic biomarkers of DR is quite extensive, whereas the awareness about epigenetics and epigenetic markers is only beginning to be understood.Modulation of epigenetic changes by pharmaceutical means may provide a potential strategy to retard the progression of DR. In addition to the intense medical management, these strategies include dietary measures (antioxidants) and the introduction of epigenetic drugs, such as inhibitors of DNA methylation and histone demethylases.

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Aberrant DNA methylation patterns in diabetic nephropathy

Cited by 48 publications

References 55 publications

The association between bone turnover markers and microvascular complications of type 2 diabetes

The association between bone turnover markers and microvascular complications of type 2 diabetes

DNA methylation and its role in the pathogenesis of diabetes

Oxidative Stress Biomarkers for Diabetic Retinopathy and Medical Management Affecting Oxidative Stress

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