Aberrant expression of miRNAs predicts recurrence and survival in stage-II colorectal cancer patients from Egypt

Bahnassy, Abeer A.; Elsayed, Mohammad; Ali, Nasr M.; Khorshid, Ola; Hussein, Marwa M.; Yousef, Hend F.; Mohanad, Marwa; Zekri, Abdel-Rahman N.; Salem, Salem E.

doi:10.1186/s41241-017-0045-5

Cited by 9 publications

(4 citation statements)

References 29 publications

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“…Thus, the discovery of tumor-derived miRNAs prompted us to increase awareness of such miRNAs for screening and monitoring human malignancies. miRNA-21 (miR-21) is overexpressed in most tumors, including: lung (Jess, Rungoe, & Peyrin-Biroulet, 2012), breast (Dong et al, 2014), stomach (Jiang et al, 2011), prostate (Zheng et al, 2014), colon (Bahnassy et al, 2017), ovarian (Mahmoud, Fawzy, & RA, 2018), head and neck (Avissar, McClean, Kelsey, & Marsit, 2009), salivary adenoid cystic carcinoma (Yan, Wang, Li, Cai, & Sun, 2018), esophagus (He et al, 2017), and pancreas (Papaconstantinou et al, 2013). Overexpression of miR-21 is a novel prognosis biomarker in malignancies and is positively associated with high proliferation and tumor growth and low tumor cells apoptosis (Lu et al, 2008).…”

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confidence: 99%

Diagnostic, prognostic, and therapeutic potency of microRNA 21 in the pathogenesis of colon cancer, current status and prospective

Bahreyni

Rezaei

Bahrami

et al. 2018

Journal Cellular Physiology

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Aberrant microRNA (miR) expression is implicated in multiple human malignancies. miR‐21, acting as a proto‐oncogene, is involved in a variety of cellular processes and tumorigenesis and is frequently overexpressed in some cancer types. Several tumor suppressors, metastatic, and apoptotic genes have been identified as miR‐21 targets, including Ras homolog gene family member B, PTEN, Sprouty2, programmed cell death 4, Integrin‐β4, and E‐cadherin thereby regulating tumor growth, invasion, and metastasis. There is a growing evidence that miR‐21 expression is associated with clinical outcomes in patients with colorectal cancer (CRC). In this review, we summarize the potential diagnostic, prognostic, and therapeutic values of miR‐21 in CRC progression for a better understanding and hence a better management of this disease.

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mentioning

confidence: 99%

Diagnostic, prognostic, and therapeutic potency of microRNA 21 in the pathogenesis of colon cancer, current status and prospective

Bahreyni

Rezaei

Bahrami

et al. 2018

Journal Cellular Physiology

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“…Dysregulation of miR-137 is associated with prognosis of CRC. The decline of miR-137 expression is able to predict recurrence and survival of stage II CRC patients [37]. Furthermore, altered miR-137 expression has been shown to be associated with the progression of CRC.…”

Section: Mirna-137mentioning

confidence: 99%

MicroRNA Methylome Signature and Their Functional Roles in Colorectal Cancer Diagnosis, Prognosis, and Chemoresistance

Baharudin

Bakarurraini

Ismail

et al. 2022

IJMS

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Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide. Despite significant advances in the diagnostic services and patient care, several gaps remain to be addressed, from early detection, to identifying prognostic variables, effective treatment for the metastatic disease, and the implementation of tailored treatment strategies. MicroRNAs, the short non-coding RNA species, are deregulated in CRC and play a significant role in the occurrence and progression. Nevertheless, microRNA research has historically been based on expression levels to determine its biological significance. The exact mechanism underpinning microRNA deregulation in cancer has yet to be elucidated, but several studies have demonstrated that epigenetic mechanisms play important roles in the regulation of microRNA expression, particularly DNA methylation. However, the methylation profiles of microRNAs remain unknown in CRC patients. Methylation is the next major paradigm shift in cancer detection since large-scale epigenetic alterations are potentially better in identifying and classifying cancers at an earlier stage than somatic mutations. This review aims to provide insight into the current state of understanding of microRNA methylation in CRC. The new knowledge from this study can be utilized for personalized health diagnostics, disease prediction, and monitoring of treatment.

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“…miRNA is secreted into the circulation through many different mechanisms [ 34 ]. Coupled with this, the degradation of miRNA through endogenous RNase has proven to be resistant and difficult due to the length of the nucleic acid, its encapsulation through exosome microvesicles, and its existence in very stable forms in bodily fluids, including serum and urine [ 35 ]; therefore, it is now believed that the study of miRNA content in bodily fluids can be used as a major biological indicator for various diseases, and its association to cancer is undeniable [ 36 , 37 , 38 ], including colorectal cancer [ 39 ], gastric cancer [ 40 ], prostate cancer [ 41 ], breast cancer [ 42 ] and ovarian cancer [ 43 ].…”

Section: Introductionmentioning

confidence: 99%

Urinary MicroRNA Sensing Using Electrochemical Biosensor to Evaluate Colorectal Cancer Progression

et al. 2022

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Research in cancer diagnostics has recently established its footing and significance in the biosensor sphere, emphasizing the idea of a unique probe design used as a sensor and actuator, to identify the presence of protein, DNA, RNA, or miRNA. The fluorescein isothiocyanate (FITC) probe and biotinylated probe are designed for a two-pronged approach to the detection of the urinary miR-21 and miR-141, both of which have demonstrated significance in the development and progression of colorectal cancer, a leading cause of mortality and morbidity. The remainder of the apparatus is composed of a modified screen-printed carbon electrode (SPCE), to which the probes adhere, that transduces signals via the redox reaction between H2O2 and HRP, measured with chronoamperometry and cyclic voltammetry. The precise nature of our ultra-non-invasive biosensor makes for a highly sensitive and practical cancer detector, concluded by the significance when establishing disease presence (miR-21 p-value = 0.0176, miR-141 p-value = 0.0032), disease follow-up (miR-21 p-value = 0.00154, miR141 p-value < 0.0005), and even disease severity. This article hopes to emphasize the potential of an additional clinical tool for the management of colorectal cancer.

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Aberrant expression of miRNAs predicts recurrence and survival in stage-II colorectal cancer patients from Egypt

Cited by 9 publications

References 29 publications

Diagnostic, prognostic, and therapeutic potency of microRNA 21 in the pathogenesis of colon cancer, current status and prospective

Diagnostic, prognostic, and therapeutic potency of microRNA 21 in the pathogenesis of colon cancer, current status and prospective

MicroRNA Methylome Signature and Their Functional Roles in Colorectal Cancer Diagnosis, Prognosis, and Chemoresistance

Urinary MicroRNA Sensing Using Electrochemical Biosensor to Evaluate Colorectal Cancer Progression

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