Aberrant expressions of annexin A10 short isoform, osteopontin and α-fetoprotein at chromosome 4q cooperatively contribute to progression and poor prognosis of hepatocellular carcinoma

Shu, Peng; Ou, Yueh‐Hsing; Chen, Wei-Jen; Li, Huei-Ying; Liu, Shu-Hsiang; Pan, Hung‐Wei; Lai, Po-Lin; Jeng, Yung‐Ming; Chen, David C P; Hsu, Hey‐Chi

doi:10.3892/ijo.26.4.1053

Cited by 19 publications

(26 citation statements)

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“…This study also showed that annexin A10 was down‐regulated in HCCs and was associated with a poor prognosis 72. Reduced expression of the short form of annexin A10 in hepatocellular carcinoma has been confirmed in a larger series of hepatocellular carcinomas 73.…”

Section: Individual Annexins and Tumour Development And Progressionsupporting

confidence: 52%

The role of annexins in tumour development and progression

Mussunoor¹,

Murray²

2008

The Journal of Pathology

265

243

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The annexins are a super-family of closely related calcium and membrane-binding proteins. They have a diverse range of cellular functions that include vesicle trafficking, cell division, apoptosis, calcium signalling and growth regulation. Many studies have shown the annexins to be among the genes whose expression are consistently differentially altered in neoplasia. Some annexins show increased expression in specific types of tumours, while others show loss of expression. Mechanistic studies relating the changes in annexin expression to tumour cell function, particularly tumour invasion and metastasis, angiogenesis and drug resistance, are now also emerging. Changes in the expression of individual annexins are associated with particular types of tumour and hence the annexins may also be useful biomarkers in the clinic.

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Section: Individual Annexins and Tumour Development And Progressionsupporting

confidence: 52%

The role of annexins in tumour development and progression

Mussunoor¹,

Murray²

2008

The Journal of Pathology

265

243

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“…It is reasonable to suggest that ANXA10 will exhibit unique tissue expression and function distinct from the ANX family. Its shorter, splicing variant, ANXA10S, which was previously mistaken as ANXA10, 25 was specifically expressed in the liver 26 . In the present study, we demonstrated that ANXA10 is a nuclear protein specifically expressed in the mucus cells of the gastric mucosa surface and foveolae, and Brunner's glands in humans and animals, including woodchucks, minipigs, and mice, but not in any other tissues.…”

Section: Discussionsupporting

confidence: 45%

“…Through the mRNA differential display screening and gene expression analysis, we showed that ANXA10 was expressed in a tissue‐restricted pattern and was limited to the liver and stomach 25 . Subsequently, we cloned an amino terminal‐truncated, shorter splicing variant lacking the first five exons, designated as ANAXA10's liver‐specific short isoform or ANXA10S (AY626137) 26 . ANXA10S, 26 which was previously mistaken as ANXA10, 25 was specifically expressed in the liver, and downregulated in HCC associated with tumor progression and poor prognosis 25,26 .…”

Section: Introductionmentioning

confidence: 99%

Expression and prognostic significance of gastric‐specific annexin A10 in diffuse‐ and intestinal‐type gastric carcinoma

Chen

Shun

et al. 2010

J of Gastro and Hepatol

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“…33,35 In this study, we demonstrated for the first time that in patients with resectable HCCs, the HCCs with HNF1β expression were associated with a significantly lower 5-year survival rate than those without HNF1β expression. Most importantly, the prognostic implications of HNF1β expression were independent of the tumor stage.…”

Section: Discussionmentioning

confidence: 87%