Aberrant features of in vivo striatal dynamics in Parkinson's disease

Abstract

The striatum plays an important role in learning, selecting, and executing actions. As a major input hub of the basal ganglia, it receives and processes a diverse array of signals related to sensory, motor, and cognitive information. Aberrant neural activity in this area is implicated in a wide variety of neurological and psychiatric disorders. It is therefore important to understand the hallmarks of disrupted striatal signal processing. This review surveys literature examining how in vivo striatal microcircuit dynamics are impacted in animal models of one of the most widely studied movement disorders, Parkinson's disease. The review identifies four major features of aberrant striatal dynamics: altered relative levels of direct and indirect pathway activity, impaired information processing by projection neurons, altered information processing by interneurons, and increased synchrony.

Inhibition of beta oscillations by delayed feedback in a cortex-basal ganglia-thalamus-pedunculopontine nucleus neural loop model

“…In BGTh, the structure of the striatum model proposed by Moran et al [28] is referenced, it contains FSI and MSN [29][30][31]. Depending on the dopamine receptors, MSN contains two types of D1 and D2 (i.e.…”

A computational model‐based analysis of basal ganglia pathway changes in Parkinson’s disease inferred from resting‐state fMRI

“…The "rate model" of PD and corresponding neurophysiological findings Due to the popularity of the so-called rate model of the basal ganglia, particularly the version of DeLong (1990), we compared the individual predictions of this rate model and our results with respect to experimental findings compiled in several reviews (DeLong & Wichmann, 2009;Galvan et al, 2015;Galvan & Wichmann, 2008;Lee & Masmanidis, 2019;McGregor & Nelson, 2019;Obeso & Lanciego, 2011;Obeso et al, 2000;Wichmann & Delong, 2002).…”