2015
DOI: 10.1016/j.neuropsychologia.2015.10.029
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Aberrant function of frontoamygdala circuits in adolescents with previous verbal abuse experiences

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Cited by 29 publications
(36 citation statements)
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References 70 publications
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“…Potentially, this strengthening of early connections (e.g., those to the thalamus and nucleus accumbens) comes at the expense of the connections that form later in development, including those to the frontal cortex (Bouwmeester et al, 2002). Support for this idea comes from the preclinical observation of aberrant functional amygdala-frontal cortex connectivity in adolescents and adults that experienced childhood adversity (Birn et al, 2014; Fan et al, 2014; Lee et al, 2015). Alternatively, these changes in connectivity could derive from the precocious closing of a critical period of plasticity through neonatal stress.…”
Section: Hpa-axis Programming By Early Life Stress (Els)mentioning
confidence: 99%
“…Potentially, this strengthening of early connections (e.g., those to the thalamus and nucleus accumbens) comes at the expense of the connections that form later in development, including those to the frontal cortex (Bouwmeester et al, 2002). Support for this idea comes from the preclinical observation of aberrant functional amygdala-frontal cortex connectivity in adolescents and adults that experienced childhood adversity (Birn et al, 2014; Fan et al, 2014; Lee et al, 2015). Alternatively, these changes in connectivity could derive from the precocious closing of a critical period of plasticity through neonatal stress.…”
Section: Hpa-axis Programming By Early Life Stress (Els)mentioning
confidence: 99%
“…Additional evidence for the association between abuse and neglect and the neural responsiveness of the threat‐processing system comes from recent studies of both previously institutionalized children (Gee et al., ) and individuals who experienced maltreatment in a community setting (Lee et al., ; Marusak, Martin, Etkin, & Thomason, ; McLaughlin, Peverill, Gold, Alves, & Sheridan, ; Puetz et al., ). As these studies primarily focussed on investigating neural connectivity across brain regions during emotion regulation, we consider them in a separate section below.…”
Section: Functional Magnetic Resonance Imaging and The Study Of Childmentioning
confidence: 99%
“…To date, seven studies with children and adolescents with histories of maltreatment have investigated the brain circuitry involved in emotion regulation (Elsey et al., ; Gee et al., ; Lee et al., ; Marusak et al., ; McLaughlin et al., ; Puetz et al., , ). The findings of these studies largely converge, indicating functional alteration in a group of brain regions implicated in emotion regulation.…”
Section: Functional Magnetic Resonance Imaging and The Study Of Childmentioning
confidence: 99%
“…Interestingly, CM associated negative PFC-amygdala connectivity in children reflected adolescent like connectivity, suggesting that CM accelerates the development of amygdala-PFC coupling (Gee et al, 2013). Others found that CM related negative PFC-limbic connectivity was related with depression symptoms (Lee et al, 2015;Wang et al, 2014). Therefore, altered PFC-limbic connectivity should be further examined for its importance in resilient functioning after CM and positive fronto-limbic connectivity may reflect a mechanism through which the PFC regulates emotions and dampens HPA axis and inflammatory responses to stress.…”
Section: Brain Functioningmentioning
confidence: 99%
“…The PFC has extensive connectivity with the limbic system, and CM has been implicated with negative PFC-amygdala connectivity (Gee et al, 2013;Jedd et al, 2015;Lee et al, 2015). Interestingly, CM associated negative PFC-amygdala connectivity in children reflected adolescent like connectivity, suggesting that CM accelerates the development of amygdala-PFC coupling (Gee et al, 2013).…”
Section: Brain Functioningmentioning
confidence: 99%