Aberrant functional connectivity in depression as an index of state and trait rumination

Rosenbaum, David; Haipt, Alina; Fuhr, K; Haeußinger, Florian B.; Metzger, Florian; Nuerk, Hans‐Christoph; Fallgatter, Andreas J.; Batra, Anil; Ehlis, Ann‐Christine

doi:10.1038/s41598-017-02277-z

Cited by 64 publications

(74 citation statements)

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“…Recent research indicates that only some depressed individuals report ruminating during resting-state scans. However, both state and trait measures of rumination have been found to be associated with functional connectivity (Kaiser et al, 2016;Rosenbaum et al, 2017). Accordingly, future studies should consider implementing a state measure of rumination assessing cognition during the resting-state scan to provide a link between the ruminative state and neural underpinnings during functional connectivity scans.…”

Section: Discussionmentioning

confidence: 99%

Functional connectivity of reflective and brooding rumination in depressed and healthy women

Satyshur

Layden

Gowins

et al. 2018

Cogn Affect Behav Neurosci

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Ruminative thinking is related to an increased risk for major depressive disorder (MDD) and perpetuates negative mood states. Rumination, uncontrollable negative thoughts about the self, may comprise both reflective and brooding components. However, only brooding rumination is consistently associated with increased negativity bias and negative coping styles, while reflective rumination has a less clear relationship with negative outcomes in healthy and depressed participants. The current study examined seed-to-voxel (S2.V) resting-state functional connectivity (FC) in a sample of healthy (HC) and depressed (MDD) adult women (HC: n=50, MDD: n=33). The S2V FC of six key brain regions, including the left and right amygdala, anterior and posterior cingulate cortex (ACC, PCC), and medial and dorsolateral prefrontal cortices (mPFC, dlPFC), was correlated with self-reported reflective and brooding rumination. Results indicate that HC and MDD participants had increased brooding rumination associated with decreased FC between the left amygdala and the right temporal pole. Moreover, reflective rumination was associated with distinct FC of the mPFC, PCC, and ACC with parietal, occipital, and cingulate regions. Depressed participants, compared with HC, exhibited decreased FC between the PCC and a region in the right middle frontal gyrus. The results of the current study add to the understanding of the neural underpinnings of different forms of self-related cognition-brooding and reflective rumination-in healthy and depressed women.

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Section: Discussionmentioning

confidence: 99%

Functional connectivity of reflective and brooding rumination in depressed and healthy women

Satyshur

Layden

Gowins

et al. 2018

Cogn Affect Behav Neurosci

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“…For each item, subjects indicate the frequency of each event on a scale ranging from 0 ("almost never") to 3 ("almost always"), yielding a range of possible scores from 0-30. The brooding subscale has high reliability (a=0.77-0.92)(Erdur-Bakera & Bugaya, 2010), is well-validated within depressed populations (Treynor et al, 2003), decontaminated of any explicitly depressive content (Treynor et al, 2003), and the sub-scale of choice for most neurobiological studies of DR (Hamilton et al, 2011;Nejad et al, 2013;Ordaz et al, 2016;Rosenbaum et al, 2017;Southworth et al, 2017). For these reasons, we used the brooding subscale exclusively to measure DR.…”

Section: Depressive Rumination Measurementmentioning

confidence: 99%

“…Four IC's were manually identified as noise and removed from further examination. Of the remaining twenty-one networks, all were identified using visual inspection by way of reference to the 17 RSN's delineated by the Yeo et al 2011atlas (Yeo et al, 2011, thus allowing for identification of the three IC's of the triple-network that were introduced above -the pDMN (Hamilton et al, 2011;Rosenbaum et al, 2017), the coSN (Wu et al, 2016), and the fECN (Bernstein et al, 2017;Dutta et al, 2014;Watkins & Brown, 2002).…”

Section: Rsfmri: Group Independent-components Analysis (Ica) / Dual-rmentioning

confidence: 99%

“…Broadly speaking, diminished Precuneal integration with the DMN may reflect impaired inhibition of internal mentation, particularly given the role of the Precuneus as a core parietal hub for maintaining conscious self-awareness (Klaassens et al, 2017). Conversely, greater segregation from frontal cognitive control modules and somatosensory areas in DR may imply globally dysregulated self-referential processing that is largely detached from present-moment sensory experience (Johnson et al, 2009;Pelletier-Baldelli et al, 2015;Rosenbaum et al, 2017).…”

Section: Pdmnmentioning

confidence: 99%

“…believed to amplify self-referential processing and thereby increase the demand on cognitive resources (Leech et al, 2011;Sheline et al, 2009). In particular, recent studies have shown that greater DR severity is associated with lower functional connectivity within a parietal sub-system of the DMN, the Precuneal DMN (pDMN), which is both vulnerable to malfunctioning under conditions of cognitive resource depletion (Wang et al, 2016), and specifically responsible for regulating the episodic memory retrieval that supports inner mentation (Rosenbaum et al, 2017).…”

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confidence: 99%

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A Reproducible Neurobiology of Depressive Rumination

Pisner

Shumake

Beevers

et al. 2018

Preprint

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Depressive Rumination (DR), which involves a repetitive focus on one’s distress, has been linked to alterations in functional connectivity of the ‘triple-network’, consisting of Default-Mode, Salience, and Executive Control networks. A structural basis for these functional alterations that can dually explain DR’s persistence as a stable trait remains unexplored, however. Using diffusion and functional Magnetic Resonance Imaging, we investigated multimodal relationships between DR severity, white-matter microstructure, and resting-state functional connectivity in depressed adults, and then directly replicated our results in a phenotypically-matched, independent sample (total N = 78). Among the fully-replicated findings, DR severity was associated with: (a) global microstructure of the right Superior Longitudinal Fasciculus and local microstructure of distributed primary-fiber and crossing-fiber white-matter; (b) an imbalance of functional connectivity segregation and integration of the triple-network; and (c) ‘multi-layer’ associations linking these microstructural and functional connectivity biomarkers to one another. Taken together, the results provide reproducible evidence for a multi-layer, microstructural-functional network model of rumination in the depressed brain.

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Intrasubject functional connectivity related to self‐generated thoughts

Brennan¹,

Murrough

Morris

2020

Brain and Behavior

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Introduction In psychiatric research, functional connectivity (FC) derived from resting‐state functional MRI (rsfMRI) is often used to investigate brain abnormalities in psychiatric disorders. This approach assumes implicitly that FC can recover reliable maps of the functional architecture of the brain and that these profiles of connectivity reflect trait differences underlying pathology. However, evidence of FC related to self‐generated thoughts (mind‐wandering) stands in contrast with these assumptions, as FC may reflect thought patterns rather than functional architecture. Methods Multi‐factor analysis (MFA) was used to investigate the reported content of self‐generated thoughts during high‐field (7T) rsfMRI in a repeated sample of 22 healthy individuals. To investigate the relationship between these experiences and FC, individual scores for each of these dimensions were compared with whole‐brain connectivity using the network‐based statistic (NBS) method. Results This analysis revealed three dimensions of thought content: self‐referential thought, negative thoughts about one's surroundings, and thoughts in the form of imagery. A network of connections within the sensorimotor cortices negatively correlated with self‐generated thoughts concerning the self was observed (p = .0081, .0486 FDR). Conclusion These results suggest a potentially confounding relationship between self‐generated thoughts and FC, and contribute to the body of research concerning the functional representation of mind‐wandering.

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Aberrant functional connectivity in depression as an index of state and trait rumination

Cited by 64 publications

References 65 publications

Functional connectivity of reflective and brooding rumination in depressed and healthy women

Functional connectivity of reflective and brooding rumination in depressed and healthy women

A Reproducible Neurobiology of Depressive Rumination

Intrasubject functional connectivity related to self‐generated thoughts

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