Aberrant Immunophenotypic Expression of CD5 in a Case of B Acute Lymphoblastic Leukemia: A Case Report

Mutreja, Deepti; Pati, Hara Prasad; Bansal, Divya; Sharma, Rahul Kumar; Jain, Sonal

doi:10.1007/s12288-014-0332-1

Cited by 13 publications

(8 citation statements)

References 8 publications

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“…All the patients described in case reports published till now correlate this entity with aggressive behaviour, described a patient of same entity with lymphadenopathy, hepatomegaly and ascites. This patient died before chemotherapy could be initiated [5]. Two patients reported showed aggressive behaviour [6] and reported a Ph positive B-cell ALL patient with aberrant CD 5 expression.…”

Section: Discussionmentioning

confidence: 90%

Aberrant Expression of a T-Cell and a Monocytic Antigen in a Newly Diagnosed Precursor B-Cell Acute Lymphoblastic Leukaemia

Siddiqui¹,

Saud²,

Ramzan³

2017

Natl. j. health sci.

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Background: Aberrant expression of antigens/or loss of some antigens on leukemic cells is sometimes seen. Such expressions may or not affect prognosis of leukaemia. Aberrant co-expression of CD5 and CD64 on precursor B-cell ALL leukemic cells is found first time.Objective: To report a novel case of precursor B-cell ALL which co-expressed a T-cell lineage (CD5) and a monocytic lineage (CD64) antigens.Methods: Bone marrow immunophenotyping was performed using FACSCalibur (a four-color flowcytometer) and acute leukaemia panel of antibodies.Case Presentation: A 4-year old boy with circulating small sized blasts. Immunophenotyping data revealed expression of CD45, CD19, CD79a, TdT, CD34, CD10, CD5 and CD64 while absence of CD3, MPO, CD13, CD33, CD4, CD7 and CD8 antigens. Conclusion:A diagnosis of precursor B-cell ALL with aberrant CD5 and CD64 expression was made.

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Section: Discussionmentioning

confidence: 90%

Aberrant Expression of a T-Cell and a Monocytic Antigen in a Newly Diagnosed Precursor B-Cell Acute Lymphoblastic Leukaemia

Siddiqui¹,

Saud²,

Ramzan³

2017

Natl. j. health sci.

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“…The patient died of pancreatitis before starting induction chemotherapy [11]. Compiling all the cases in the literature, aberrant expression of CD 5 is reported only in 15 cases [3,4,6,[9][10][11]. They are summarized in Table 1.…”

Section: Discussionmentioning

confidence: 96%

CD5 Positive B Lymphoblastic Leukemia: Report of a Case with Review of Literature

Sreedharanunni

Kumar²,

Khadwal

2014

Indian J Hematol Blood Transfus

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We report a rare CD5 positive B cell acute lymphoblastic leukemia (B-ALL) with a review of the clinopathological features and prognosis of previously reported cases in the literature. The aberrant expression of CD 5 antigen is uncommon in B-ALL; the morphological differential diagnosis includes blastic mantle cell lymphoma, denovo CD5(+) diffuse large B cell lymphoma and secondary diffuse large cell lymphoma/Richter's transformation. CD5(+) B cell ALL is commonly reported in younger patients (<18 years). Though the expression of T cell antigens is reported to have poor prognosis, the experience with CD5(+) B-ALL is limited to draw any firm conclusion regarding its prognosis.

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“…Additionally, there was no assessment for t(11;14) translocation or cyclin D1 positivity . However, while lack of TdT and/or CD45 expression is not typical of B‐ALL, it is hardly rare, as it has been reported in as many as 10% and 30% of cases, respectively . Furthermore, lack of surface immunoglobulin (sIg), negative cytogenetics, and the patient's clinical presentation (hepatosplenomegaly) suggest C5 + B‐ALL was the appropriate diagnosis .…”

Section: Discussionmentioning

confidence: 99%

CD5 positive B‐ALL, a uniquely aggressive subcategory of B‐ALL? A case report and brief review of the literature

Staley

Feldman

Koenig

et al. 2018

Pediatric Blood & Cancer

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CD5 antigen expression in B-cell acute lymphoblastic leukemia (B-ALL) is exceptionally rare. There are six detailed case reports in the literature, with only 16 cases described. Case series analyzing the frequency of aberrant B-ALL immunophenotypes suggest that this variant may occur in as little as 2-4.5% of all B-ALL cases, with one series having no CD5 + positive cases. Herein we report a case of CD5 + B-ALL in a 15-year-old female, and review the previously reported cases. As limited information is available, more data from prospective clinical trials are required to determine whether CD5 positivity portends a poorer prognosis. K E Y W O R D S acute lymphoblastic leukemia, B-cell ALL, CD5 + , immunophenotypic aberrancies in ALL, variant B-ALL

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Aberrant Immunophenotypic Expression of CD5 in a Case of B Acute Lymphoblastic Leukemia: A Case Report

Cited by 13 publications

References 8 publications

Aberrant Expression of a T-Cell and a Monocytic Antigen in a Newly Diagnosed Precursor B-Cell Acute Lymphoblastic Leukaemia

Aberrant Expression of a T-Cell and a Monocytic Antigen in a Newly Diagnosed Precursor B-Cell Acute Lymphoblastic Leukaemia

CD5 Positive B Lymphoblastic Leukemia: Report of a Case with Review of Literature

CD5 positive B‐ALL, a uniquely aggressive subcategory of B‐ALL? A case report and brief review of the literature

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