Aberrant Methylation of T-cadherin Can Be a Diagnostic Biomarker for Colorectal Cancer

Duan, Bo-Shi; Xie, Longfei; Wang, Yue

doi:10.21873/cgp.20038

Cited by 9 publications

(8 citation statements)

References 17 publications

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“…Canhoroz [15] who measured tissue APN expression also showed that this is not associated with DFS. This study was also limited by the small number of patients recruited [15]. T-cadherin receptor which binds the biologically most active HMW isoform is less well studied but was investigated by Duan et al [16].…”

Section: Adiponectin (Apn)mentioning

confidence: 97%

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The prognostic and therapeutic role of hormones in colorectal cancer: a review

et al. 2018

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Colorectal cancer (CRC) is one of the commonest cancers in Western society with a poor prognosis in patients with advanced disease. Targeted therapy is of increasing interest and already, targeted hormone treatment for breast and prostate cancer has improved survival. The aim of this literature review is to summarise the role of hormones in CRC prognosis and treatment. A literature review of all human and animal in vivo and in vitro studies in the last 20 years, which assessed the role of hormones in CRC treatment or prognosis, was carried out. The hormones described in this review have been subdivided according to their secretion origin. Most of the studies are based on in vitro or animal models. The main findings point to adipokines, insulin and the insulin growth factor axis as key players in the link between obesity, type 2 diabetes mellitus and a subset of CRC. Gut-derived hormones, especially uroguanylin and guanylin are being increasingly investigated as therapeutic targets, with promising results. Using hormones as prognostic and therapeutic markers in CRC is still in the preliminary stages for only a fraction of the hormones affecting the GIT. In light of the increasing interest in tailoring treatment strategies, hormones are an important area of focus in the future of CRC management.

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Section: Adiponectin (Apn)mentioning

confidence: 97%

“…However only 58 patients were recruited in this study and their body mass index (BMI) was not known [12]. Canhoroz [15] who measured tissue APN expression also showed that this is not associated with DFS. This study was also limited by the small number of patients recruited [15].…”

Section: Adiponectin (Apn)mentioning

confidence: 99%

The prognostic and therapeutic role of hormones in colorectal cancer: a review

et al. 2018

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“…Because CDH13 promoter methylation is common in many human tumors, it has been suggested as an early detection and prognostic marker for human malignancies [ 27 , 46 , 49 ], particularly colorectal [ 40 , 41 ], breast [ 34 ], and non-small cell lung cancer (NSCLC) [ 29 , 32 , 33 ]. The methylation site, cg02263260, located in the promoter region of CDH13 might be important in assessing breast cancer risk and prognosis [ 49 ].…”

Section: Introductionmentioning

confidence: 99%

Interactive association between dietary fat and sex on CDH13 cg02263260 methylation

Shiu

Tantoh

et al. 2021

BMC Med Genomics

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Background DNA methylation of Cadherin 13 (CDH13), a tumor suppressor gene is associated with gene repression and carcinogenesis. We determined the relation of dietary fat and sex with CDH13 cg02263260 methylation in Taiwanese adults. Methods Data of 870 eligible participants (430 men and 440 women) between 30 and 70 years were obtained from the Taiwan Biobank (TWB) database. The association of dietary fat and sex with CDH13 cg02263260 methylation was determined using multiple linear regression. Results The association between sex and cg02263260 methylation was significant: beta-coefficient (β) = 0.00532; 95% confidence interval (CI) = 0.00195–0.00868. Moreover, the interaction between sex and dietary fat on cg02263260 methylation was significant (P-value = 0.0145). After stratification by sex, the association of dietary fat with cg02263260 methylation was significant only in women. Specifically, high dietary fat was positively associated with cg02263260 methylation in women (β = 0.00597; 95% CI = 0.00061–0.01133) and the test for trend was significant (P-value = 0.0283). Conclusion High fat intake was significantly associated with higher cg02263260 methylation in women and the test for trend was significant. These findings suggest that the association of fat intake and CDH13 cg02263260 might vary by sex and CDH13 cg02263260 methylation levels in women might increase as fat intake increases.

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“…[3–5] In many Asian countries, the incidence of CRC has increased 2 to 4 times over the past few decades. [6–8] Despite improvements in treatment strategies in recent years, the overall survival rate of CRC is still very low. [8] The survival rate of CRC depends to a large extent on the stage of the disease at the time of diagnosis.…”

Section: Introductionmentioning

confidence: 99%

“…[6–8] Despite improvements in treatment strategies in recent years, the overall survival rate of CRC is still very low. [8] The survival rate of CRC depends to a large extent on the stage of the disease at the time of diagnosis. [9] The 5-year survival rate for CRC patients detected at the local stage is about 90% after curative surgery, 70% for regional patients, and approximately 10% for patients with disseminated disease.…”

Section: Introductionmentioning

confidence: 99%