Aberrant promoter methylation and expression of the imprinted PEG3 gene in glioma

Otsuka, Susumu; Maegawa, Satoru; Takamura, Ayumi; Kamitani, Hideki; Watanabe, Takashi; Oshimura, Mitsuo; Nanba, Eiji

doi:10.2183/pjab.85.157

Cited by 27 publications

(21 citation statements)

References 30 publications

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“…The expressions of Cdkn1a and Wee1 kinase show opposite circadian phases, with peak expression of Cdkn1a occurring at the transition from dark to light period (cluster 1, ZT 0) and peak expression of Wee1 occurring at the early dark period (cluster 5, ZT 16). Almost all genes present in this grouping are found to be differentially regulated in various cancers (20,33,35,41).…”

Section: Resultsmentioning

confidence: 96%

Circadian variations in gene expression in rat abdominal adipose tissue and relationship to physiology

Sukumaran

Xue²,

Jusko³

et al. 2010

Physiological Genomics

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Circadian rhythms occur in all levels of organization from expression of genes to complex physiological processes. Although much is known about the mechanism of the central clock in the suprachiasmatic nucleus, the regulation of clocks present in peripheral tissues as well as the genes regulated by those clocks is still unclear. In this study, the circadian regulation of gene expression was examined in rat adipose tissue. A rich time series involving 54 animals euthanized at 18 time points within the 24-h cycle (12:12 h light-dark) was performed. mRNA expression was examined with Affymetrix gene array chips and quantitative real-time PCR, along with selected physiological measurements. Transcription factors involved in the regulation of central rhythms were examined, and 13 showed circadian oscillations. Mining of microarray data identified 190 probe sets that showed robust circadian oscillations. Circadian regulated probe sets were further parsed into seven distinct temporal clusters, with >70% of the genes showing maximum expression during the active/dark period. These genes were grouped into eight functional categories, which were examined within the context of their temporal expression. Circadian oscillations were also observed in plasma leptin, corticosterone, insulin, glucose, triglycerides, free fatty acids, and LDL cholesterol. Circadian oscillation in these physiological measurements along with the functional categorization of these genes suggests an important role for circadian rhythms in controlling various functions in white adipose tissue including adipogenesis, energy metabolism, and immune regulation.

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Section: Resultsmentioning

confidence: 96%

Circadian variations in gene expression in rat abdominal adipose tissue and relationship to physiology

Sukumaran

Xue²,

Jusko³

et al. 2010

Physiological Genomics

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“…Currently, approximately 80 imprinted genes have been characterized in the mouse genome. Two-thirds of them show conserved imprinting patterns between mice and humans, whereas others show imprinting patterns specific to humans.…”

Section: Introductionmentioning

confidence: 99%

Loss of Imprinting as an Epigenetic Marker in Bladder Cancer

Reis¹,

Rainho²

2013

Advances in the Scientific Evaluation of Bladder Cancer and Molecular Basis for Diagnosis and Treatment

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“…208 In glioma, ovarian and other gynaecological cancers, PEG3 was found to be silenced by DNA hypermethylation of the DMR, which could be relieved by demethylating drugs, especially in combination with a histone deacetylase inhibitor. [209][210][211][212][213] Interestingly, the methylation of the intragenic PEG3 DMR correlated also with the expression of the neighbouring ITUP1 gene oriented head-to-head to PEG3. 214 The PEG3 gene product is a Krüppel-type zinc finger protein.…”

Section: Peg3mentioning

confidence: 94%

Specific changes in the expression of imprinted genes in prostate cancer—implications for cancer progression and epigenetic regulation

Ribarska¹,

Bastian²,

Koch³

et al. 2012

Asian J Androl

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Epigenetic dysregulation comprising DNA hypermethylation and hypomethylation, enhancer of zeste homologue 2 (EZH2) overexpression and altered patterns of histone modifications is associated with the progression of prostate cancer. DNA methylation, EZH2 and histone modifications also ensure the parental-specific monoallelic expression of at least 62 imprinted genes. Although it is therefore tempting to speculate that epigenetic dysregulation may extend to imprinted genes, expression changes in cancerous prostates are only well documented for insulin-like growth factor 2 (IGF2). A literature and database survey on imprinted genes in prostate cancer suggests that the expression of most imprinted genes remains unchanged despite global disturbances in epigenetic mechanisms. Instead, selective genetic and epigenetic changes appear to lead to the inactivation of a sub-network of imprinted genes, which might function in the prostate to limit cell growth induced via the PI3K/Akt pathway, modulate androgen responses and regulate differentiation. Whereas dysregulation of IGF2 may constitute an early change in prostate carcinogenesis, inactivation of this imprinted gene network is rather associated with cancer progression.

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Aberrant promoter methylation and expression of the imprinted PEG3 gene in glioma

Cited by 27 publications

References 30 publications

Circadian variations in gene expression in rat abdominal adipose tissue and relationship to physiology

Circadian variations in gene expression in rat abdominal adipose tissue and relationship to physiology

Loss of Imprinting as an Epigenetic Marker in Bladder Cancer

Specific changes in the expression of imprinted genes in prostate cancer—implications for cancer progression and epigenetic regulation

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