Aberrant regional homogeneity in post-traumatic stress disorder after traffic accident: A resting-state functional MRI study

Fu, Shishun; Ma, Xiaofen; Li, Changhong; Wang, Tianyue; Li, Chao; Bai, Zhigang; Hua, Kelei; Yin, Yi; Wu, Yi‐Long; Yu, Kanghui; Liu, Mengchen; Ke, Qiying; Jian-guo, Tian; Jiang, Guihua

doi:10.1016/j.nicl.2019.101951

Cited by 10 publications

(10 citation statements)

References 59 publications

(64 reference statements)

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“…Stronger connectivity with the medial temporal lobe was shown during recovery of information, when compared to the left angular gyrus 88 . Previous studies have explored regional spontaneous brain activity (called regional homogeneity, or ReHo) changes in PTSD patients who suffered severe traffic accidents 89 . Relative to controls, participants with PTSD showed weaker right angular gyrus ReHo, and a negative correlation of right angular gyrus with CAPS scores.…”

Section: Discussionmentioning

confidence: 99%

An exploratory study of resting-state functional connectivity of amygdala subregions in posttraumatic stress disorder following trauma in adulthood

Leite

Esper

Lopes

et al. 2022

Sci Rep

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We carried out an exploratory study aimed at identifying differences in resting-state functional connectivity for the amygdala and its subregions, right and left basolateral, centromedial and superficial nuclei, in patients with Posttraumatic Stress Disorder (PTSD), relative to controls. The study included 10 participants with PTSD following trauma in adulthood (9 females), and 10 controls (9 females). The results suggest PTSD was associated with a decreased (negative) functional connectivity between the superficial amygdala and posterior brain regions relative to controls. The differences were observed between right superficial amygdala and right fusiform gyrus, and between left superficial amygdala and left lingual and left middle occipital gyri. The results suggest that among PTSD patients, the worse the PTSD symptoms, the lower the connectivity. The results corroborate the fMRI literature that shows PTSD is associated with weaker amygdala functional connectivity with areas of the brain involved in sensory and perceptual processes. The results also suggest that though the patients traumatic experience occured in adulthood, the presence of early traumatic experiences were associated with negative connectivity between the centromedial amygdala and sensory and perceptual regions. We argue that the understanding of the mechanisms of PTSD symptoms, its behaviors and the effects on quality of life of patients may benefit from the investigation of brain function that underpins sensory and perceptual symptoms associated with the disorder.

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Section: Discussionmentioning

confidence: 99%

An exploratory study of resting-state functional connectivity of amygdala subregions in posttraumatic stress disorder following trauma in adulthood

Leite

Esper

Lopes

et al. 2022

Sci Rep

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“… Zhan et al (2016) reported that reduced spontaneous neural activity in acute mTBI patients might be linked with emotional and cognitive disorders ( Zhan et al, 2016 ). fALFF and ReHo are common analytical methods used for investigating the pathophysiology of various neuropsychological disorders ( Zhan et al, 2015 ; Yang et al, 2018 ; Fu et al, 2019 ; Wang et al, 2019 ; Che et al, 2020 ; Mo et al, 2020 ). In this study, we took advantage of these tools to explore the neurological mechanism of chronic mTBI and its relationship with cognitive performance.…”

Section: Discussionmentioning

confidence: 99%

“…They also have found a negative correlation between decreased ReHo values in the right AG and symptom severity of PTSD (CAPS). The researchers concluded that ReHo alteration in the AG is a common feature of PTSD that could be associated with dissociative symptoms of PTSD ( Fu et al, 2019 ). The results of our study are consistent with this conclusion, as we have observed increased ReHo values in the right AG that were negatively associated with clinical scores including RPQ-13 and trail making A.…”

Section: Discussionmentioning

confidence: 99%

Resting-State Functional MRI Metrics in Patients With Chronic Mild Traumatic Brain Injury and Their Association With Clinical Cognitive Performance

Vedaei

Newberg

Alizadeh

et al. 2021

Front. Hum. Neurosci.

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Mild traumatic brain injury (mTBI) accounts for more than 80% of people experiencing brain injuries. Symptoms of mTBI include short-term and long-term adverse clinical outcomes. In this study, resting-state functional magnetic resonance imaging (rs-fMRI) was conducted to measure voxel-based indices including fractional amplitude of low-frequency fluctuation (fALFF), regional homogeneity (ReHo), and functional connectivity (FC) in patients suffering from chronic mTBI; 64 patients with chronic mTBI at least 3 months post injury and 40 healthy controls underwent rs-fMRI scanning. Partial correlation analysis controlling for age and gender was performed within mTBI cohort to explore the association between rs-fMRI metrics and neuropsychological scores. Compared with controls, chronic mTBI patients showed increased fALFF in the left middle occipital cortex (MOC), right middle temporal cortex (MTC), and right angular gyrus (AG), and increased ReHo in the left MOC and left posterior cingulate cortex (PCC). Enhanced FC was observed from left MOC to right precuneus; from right MTC to right superior temporal cortex (STC), right supramarginal, and left inferior parietal cortex (IPC); and from the seed located at right AG to left precuneus, left superior medial frontal cortex (SMFC), left MTC, left superior temporal cortex (STC), and left MOC. Furthermore, the correlation analysis revealed a significant correlation between neuropsychological scores and fALFF, ReHo, and seed-based FC measured from the regions with significant group differences. Our results demonstrated that alterations of low-frequency oscillations in chronic mTBI could be representative of disruption in emotional circuits, cognitive performance, and recovery in this cohort.

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“…The second method was an FDR correction ( p < 0.05) [ 50 , 51 ]. The third strategy was a PT containing 5000 permutations with TFCE, which has been reported to reach the optimal balance between family-wise error rate (< 5%) and test-retest reliability and showed optimal results in recent fMRI studies [ 20 , 52 , 53 ]. Age was also included as a covariate factor in the statistical analysis, with a previous study indicating an association between age and functional activity [ 54 ].…”

Section: Methodsmentioning

confidence: 99%

Altered spontaneous neural activity in the precuneus, middle and superior frontal gyri, and hippocampus in college students with subclinical depression

Zhang

Liu

et al. 2021

BMC Psychiatry

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Background Subclinical depression (ScD) is a prevalent condition associated with relatively mild depressive states, and it poses a high risk of developing into major depressive disorder (MDD). However, the neural pathology of ScD is still largely unknown. Identifying the spontaneous neural activity involved in ScD may help clarify risk factors for MDD and explore treatment strategies for mild stages of depression. Methods A total of 34 ScD subjects and 40 age-, sex-, and education-matched healthy controls were screened from 1105 college students. The amplitude of low-frequency fluctuation (ALFF) and regional homogeneity (ReHo) of resting-state fMRI were calculated to reveal neural activity. Strict statistical strategies, including Gaussian random field (GRF), false discovery rate (FDR), and permutation test (PT) with threshold-free cluster enhancement (TFCE), were conducted. Based on the altered ALFF and ReHo, resting-state functional connectivity (RSFC) was further analyzed using a seed-based approach. Results The right precuneus and left middle frontal gyrus (MFG) both showed significantly increased ALFF and ReHo in ScD subjects. Moreover, the left hippocampus and superior frontal gyrus (SFG) showed decreased ALFF and increased ReHo, respectively. In addition, ScD subjects showed increased RSFC between MFG and hippocampus compared to healthy controls, and significant positive correlation was found between the Beck Depression Inventory-II (BDI-II) score and RSFC from MFG to hippocampus in ScD group. Conclusion Spontaneous neural activities in the right precuneus, left MFG, SFG, and hippocampus were altered in ScD subjects. Functional alterations in these dorsolateral prefrontal cortex and default mode network regions are largely related to abnormal emotional processing in ScD, and indicate strong associations with brain impairments in MDD, which provide insight into potential pathophysiology mechanisms of subclinical depression.

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Aberrant regional homogeneity in post-traumatic stress disorder after traffic accident: A resting-state functional MRI study

Cited by 10 publications

References 59 publications

An exploratory study of resting-state functional connectivity of amygdala subregions in posttraumatic stress disorder following trauma in adulthood

An exploratory study of resting-state functional connectivity of amygdala subregions in posttraumatic stress disorder following trauma in adulthood

Resting-State Functional MRI Metrics in Patients With Chronic Mild Traumatic Brain Injury and Their Association With Clinical Cognitive Performance

Altered spontaneous neural activity in the precuneus, middle and superior frontal gyri, and hippocampus in college students with subclinical depression

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