Aberrant TGF-β1 signaling activation by MAF underlies pathological lens growth in high myopia

Zhu, Xiangjia; Du, Yu; Li, Dan; Xu, Jie; Wu, Qing-Feng; He, Wenwen; Zhang, Keke; Guo, Li; Qi, Ming; Liu, Ailin; Qi, Jiao; Wang, Guangyu; Meng, Jiaqi; Yang, Zhenglin; Zhang, Kang; Lü, Yi

doi:10.1038/s41467-021-22041-2

Cited by 42 publications

(38 citation statements)

References 44 publications

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“…Considering the impact of lens in refractive system among elder individuals, we used axial length in definition of high myopia referring to previously conducted studies. [21][22][23][24][25] High myopia was defined as AL≥26 mm. Age and sex matched controls were recruited from hospital employees and volunteers from the public.…”

Section: Methodsmentioning

confidence: 99%

Corneal Biometric Features and Their Association With Axial Length in High Myopia

Jin

Liu

Wang

et al. 2022

American Journal of Ophthalmology

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Section: Methodsmentioning

confidence: 99%

Corneal Biometric Features and Their Association With Axial Length in High Myopia

Jin

Liu

Wang

et al. 2022

American Journal of Ophthalmology

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“…As the crystalline lens were the core refracting medium of the eye, 27 thus it may be a critical step to understand the changes of the crystalline lens to prevent HM. Previous studies suggested no difference in lens thickness 28–30 but larger in lens diameter size 12 in highly myopic eyes compared to emmetropic eyes. In our present study, various energy metabolic-related gene sets were enriched in the lens epithelia of HM eyes, which indicated more lens content is produced in HM eyes.…”

Section: Discussionmentioning

confidence: 88%

“…The HM-related data set GSE136701 12 was downloaded from Gene Expression Omnibus ( https://www.ncbi.nlm.nih.gov/geo/ ). GSE136701 contains gene expression profiles based on the GPL570 of lens epithelia from three human highly myopic eyes and three emmetropic control eyes and was based on the GPL570 platform.…”

Section: Methodsmentioning

confidence: 99%

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Identification of the Potential Key Genes and Pathways Involved in Lens Changes of High Myopia

Lai¹,

Wu²,

Liang³

2022

IJGM

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Aim High myopia (HM) is a global problem; however, the molecular pathogenesis of HM underlying lens remains largely unknown. The aims of the present study were to identify the potential key genes and pathways involved in lens changes of HM. Methods Gene set enrichment analysis was carried out to identify the HM-specific pathway gene sets. The differentially expressed genes (DEGs) in lens epithelia of HM eyes compared to emmetropic control were screened using limma R package. A DEG-based protein–protein interaction network was constructed and used to identify hub genes and gene cluster analysis. The functional enrichment analysis was performed to reveal the potential biological functions for each gene cluster. Results Multiple metabolism-related pathways were significantly enriched in lens epithelia of HM. The expression patterns of DEGs could accurately distinguish HM and emmetropic and CD34, CD40, EGF, IL1A, CD40LG, and CXCL12 maybe the potential key genes involved in HM. Three gene clusters were identified and involved in distinct pathways. MAPK signaling pathway and calcium signaling pathway were considered the key pathways involved in lens changes of HM, due to two gene clusters both involve in these two pathways. Conclusion We identified potential key genes in pathological lens growth of HM eyes and proposed that the imbalances of MAPK signaling pathway and calcium signaling pathway may be the two crucial steps of pathological lens growth in HM.

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“…As specified by ISO 11979-3, premarketing testing of the mechanical properties of IOLs intended for capsular bag implantation that determine angle of contact in addition to other endpoints is done with placement of the IOL in a single-size (10 mm) compression well [14]. However, it is well known that the anatomy and capsular bag size vary among eyes, increasing with increasing axial length [15][16][17][18]. Furthermore, as a result of capsular bag fibrosis, capsular bag size decreases postoperatively and in an unpredictable manner [17].…”

Section: Introductionmentioning

confidence: 99%

Geometry of Acrylic, Hydrophobic IOLs and Changes in Haptic–Capsular Bag Relationship According to Compression and Different Well Diameters: A Bench Study Using Computed Tomography

Borkenstein

2022

Ophthalmol Ther

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Introduction: Characteristics of the haptics and optic-haptic junction (OHJ) of an intraocular lens (IOL) affect IOL position in the capsular bag, positional stability, and the development of posterior capsule opacification. Therefore, the haptics and OHJ have a role in determining initial and long-term visual outcomes after cataract surgery. Understanding differences in the haptics and OHJ of available IOLs and in the relationships between the haptics of each IOL and the capsular bag across a range of capsular bag sizes might inform selection of an IOL model for individuals. Purpose: To evaluate the geometry of five currently marketed, commonly used one-piece hydrophobic acrylic monofocal IOLs and changes in haptic-capsular bag relationships according to capsular bag size using a range of compression well diameters. Methods: AcrySof SN60WF, CT LUCIA 621PY, enVista MX60, TECNIS ZCB00, and Vivinex XY1 IOLs were scanned with computed tomography (CT) in a dry, uncompressed state for quantitative analyses of haptic and OHJ dimensions and qualitative assessment of

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Aberrant TGF-β1 signaling activation by MAF underlies pathological lens growth in high myopia

Cited by 42 publications

References 44 publications

Corneal Biometric Features and Their Association With Axial Length in High Myopia

Corneal Biometric Features and Their Association With Axial Length in High Myopia

Identification of the Potential Key Genes and Pathways Involved in Lens Changes of High Myopia

Geometry of Acrylic, Hydrophobic IOLs and Changes in Haptic–Capsular Bag Relationship According to Compression and Different Well Diameters: A Bench Study Using Computed Tomography

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