Abies spectabilis-Mediated Silver Nanoparticles Inhibits Cell Growth and Promotes Apoptosis in Breast Cancer MCF-7 Cells

Ren, Guoyu; Hao, Xiao‐Jiang; Yan, Shuyi; Guo-bin, Qiu; Ang, Kok Pian; Tamrin, Mohd Islahuddin Mohd

doi:10.1615/jenvironpatholtoxicoloncol.2021039805

Cited by 3 publications

(2 citation statements)

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“…The current study's significant increase in LPO levels and a reduction in GPx activity and GSH contents suggest that 5‐FU and SiNP may synergistically raise the production of ROS, generating oxidative stress (Afrin et al, 2021; Akyuva & Nazıroğlu, 2023). These findings correspond with those of MCF‐7 breast tumors (Hamida et al, 2020) and Hep2 tumoral cells from the liver (Rank Miranda et al, 2020; Ren et al, 2022), which observed that SiNPs enhanced LPO while reducing levels of GSH and activity of GPx when compared with untreated cells.…”

Section: Discussionsupporting

confidence: 81%

Silver nanoparticles stimulate 5‐Fluorouracil‐induced colorectal cancer cells to kill through the upregulation TRPV1‐mediated calcium signaling pathways

Kaya

2024

Cell Biology International

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The involvement of the TRP vanilloid 1 (TRPV1) cation channel on the 5‐Fluorouracil (5‐FU)‐caused Ca2+ signals through the activation of the apoptotic signaling pathway and stimulating the mitochondrial Ca2+ and Zn2+ accumulation‐induced reactive oxygen species (ROS) productions in several cancer cells, except the colorectal cancer (HT‐29) cell line, was recently reported. I aimed to investigate the action of silver nanoparticles (SiNPs) and 5‐FU incubations through the activation of TRPV1 on ROS, apoptosis, and cell death in the HT‐29 cell line. The cells were divided into four groups: control, SiNP (100 µM for 48 h), 5‐FU (25 μM for 24 h), and 5‐FU + SiNP. SiNP treatment through TRPV1 activation (via capsaicin) stimulated the oxidant and apoptotic actions of 5‐FU in the cells, whereas they were diminished in the cells by the TRPV1 antagonist (capsazepine) treatment. The apoptotic and cell death actions of 5‐FU were determined by increasing the propidium iodide/Hoechst rate, caspase‐3, ‐8, and ‐9 activations, mitochondrial membrane depolarization, lipid peroxidation, and ROS, but decreasing the glutathione and glutathione peroxidase. The increase of cytosolic free Ca2+ and Zn2+ into mitochondria via the stimulation of TRPV1 current density increased oxidant and apoptotic properties of 5‐FU in the cells. For the therapy of HT‐29 tumor cells, I found that the combination of SiNPs and 5‐FU was synergistic via TRPV1 activation.

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Section: Discussionsupporting

confidence: 81%

Silver nanoparticles stimulate 5‐Fluorouracil‐induced colorectal cancer cells to kill through the upregulation TRPV1‐mediated calcium signaling pathways

Kaya

2024

Cell Biology International

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“…Initially silver NPs were used as antimicrobial agents due to their cytotoxicity ( Panáček et al, 2018 ). It was subsequently proved to kill tumor cells through inducing cellular oxidative stress and affecting mitochondrial membrane stability in vivo and in vitro experiments ( Cao et al, 2022 ; Ren et al, 2022 ; Skóra et al, 2022 ). As a result, silver nanomaterials have become a hot research topic in tumor therapy.…”

Section: Biocompatibility and Safety Of Nanomaterialsmentioning

confidence: 99%

Nanotechnology-Based Diagnostic and Therapeutic Strategies for Neuroblastoma

et al. 2022

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Neuroblastoma (NB), as the most common extracranial solid tumor in childhood, is one of the critical culprits affecting children’s health. Given the heterogeneity and invisibility of NB tumors, the existing diagnostic and therapeutic approaches are inadequate and ineffective in early screening and prognostic improvement. With the rapid innovation and development of nanotechnology, nanomedicines have attracted widespread attention in the field of oncology research for their excellent physiological and chemical properties. In this review, we first explored the current common obstacles in the diagnosis and treatment of NB. Then we comprehensively summarized the advancements in nanotechnology-based multimodal synergistic diagnosis and treatment of NB and elucidate the underlying mechanisms. In addition, a discussion of the pending challenges in biocompatibility and toxicity of nanomedicine was conducted. Finally, we described the development and application status of nanomaterials against some of the recognized targets in the field of NB research, and pointed out prospects for nanomedicine-based precision diagnosis and therapy of NB.

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Silver nanoparticles potentiate antitumor and oxidant actions of cisplatin via the stimulation of TRPM2 channel in glioblastoma tumor cells

Akyuva

Nazıroğlu²

2023

Chemico-Biological Interactions

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Abies spectabilis-Mediated Silver Nanoparticles Inhibits Cell Growth and Promotes Apoptosis in Breast Cancer MCF-7 Cells

Cited by 3 publications

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Silver nanoparticles stimulate 5‐Fluorouracil‐induced colorectal cancer cells to kill through the upregulation TRPV1‐mediated calcium signaling pathways

Silver nanoparticles stimulate 5‐Fluorouracil‐induced colorectal cancer cells to kill through the upregulation TRPV1‐mediated calcium signaling pathways

Nanotechnology-Based Diagnostic and Therapeutic Strategies for Neuroblastoma

Silver nanoparticles potentiate antitumor and oxidant actions of cisplatin via the stimulation of TRPM2 channel in glioblastoma tumor cells

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