Ability and Reproducibility of Fourier-Domain Optical Coherence Tomography to Detect Retinal Nerve Fiber Layer Atrophy in Parkinson's Disease

Characterization of retinal architecture in Parkinson's disease

“…While our findings are in line with other studies [16,17], several groups have found significant thinning of pRNFL in PD compared to HC [18][19][20][21]. We also found that the TMV was significantly reduced in patients with PD compared to HC.…”

Reliability and validity of Cirrus and Spectralis optical coherence tomography for detecting retinal atrophy in Alzheimer’s disease

“…The Spectralis OCT is more reliable and more readily detects retinal pathologies than the Cirrus OCT. 24,25 Various reports on Fourier-domain (FD) OCT in healthy and pathologic subjects have been published, 11,23,25 but no studies have evaluated the reliability of FD-OCT measurements on eyes from AD patients or measurements provided by different FD-OCT devices.…”

“…Numerous studies have analysed the ability of OCT to detect RNFL thickness abnormalities and changes in the macula of patients with neurodegenerative diseases. 10,11 Retrograde loss of nerve fibres in the retina and optic nerve may be an early biomarker of neurodegeneration in AD, even before hippocampal damage, which leads to memory impairment. 12 Recent studies have revealed the value of RNFL and macular measurements provided by OCT for detecting neurodegenerative disease progression and facilitating the diagnosis of diseases such as multiple sclerosis 10,13,14 and Parkinson's disease.…”

Ganglion Cell–Inner Plexiform Layer Thickness in Retinal Diseases: Repeatability Study of Spectral-Domain Optical Coherence Tomography

“…7,8 Recently, as interest in the ganglion cell-inner plexiform layer has grown, SD OCT has been found to be useful for the investigation of glaucoma and optic nerve and macular diseases. 6,[9][10][11][12][13][14][15][16] The ganglion cell-inner plexiform layer thickness can be measured directly using a manual method or automatically using auto-segmentation to measure the thickness of each layer of the OCT images. 17 Auto-segmentation may be affected by retinal elevation or atrophy, and the repeatability also could be affected.…”