Ability of the ALBI grade to predict posthepatectomy liver failure and long-term survival after liver resection for different BCLC stages of HCC

Zhang, Zequn; Li, Xiong; Zhou, Jiangjiao; Miao, Xiangshui; Li, Qinglong; Wen, Yu; Zou, Heng

doi:10.1186/s12957-018-1500-9

Cited by 55 publications

(57 citation statements)

References 37 publications

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“…The disease outcomes of HCC patients post-liver resection is partly affected by the existing liver physiological status. In accordance with previous studies [10,13,31,32], we determined that ALBI grade could in uence the OS of the total cohort and tumor size ≤7 cm subgroup. The patients who had an ALBI grade 1 presented a better survival time compared to those had an ALBI grade 2 in the total cohort.…”

Section: Discussionsupporting

confidence: 73%

Prognostic value of the ALBI grade among patients with single hepatocellular carcinoma without macrovascular invasion

Chen

Zhang

Wang

et al. 2020

Preprint

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Background: Although evidence for the application of albumin–bilirubin (ALBI) grading system to assess liver function in hepatocellular carcinoma (HCC) is available, less is known whether it can be applied to determine the prognosis of single HCC with different tumor sizes. This study aimed to address this gap.Methods: Here, we enrolled patients who underwent hepatectomy due to single HCC from the year 2010 to 2014. Analyses were performed to test the potential of ALBI grading system to monitor the long-term survival of single HCC subjects with varying tumor sizes.Results: Overall, 265 participants were recruited. The overall survival (OS) among patients whose tumors were ≤ 7 cm was remarkably higher compared to those whose tumors were > 7 cm. The Cox proportional hazards regression model identified the tumor differentiation grade, ALBI grade, and maximum tumor size as key determinants of the OS. The ALBI grade could stratify the patients who had a single tumor ≤ 7 cm into two distinct groups with different prognoses. The OS between ALBI grades 1 and 2 was comparable for patients who had a single tumor > 7 cm.Conclusions: We show that ALBI grading system can predict disease outcomes of single HCC patients with tumor size ≤ 7 cm. However, the ALBI grade may not predict capability the prognosis of patients with single tumor > 7 cm.

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Section: Discussionsupporting

confidence: 73%

Prognostic value of the ALBI grade among patients with single hepatocellular carcinoma without macrovascular invasion

Chen

Zhang

Wang

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…The disease outcomes of HCC patients post-liver resection is partly affected by the existing liver physiological status. In accordance with previous studies 10,11,25,26 , we determined that ALBI grade could in uence the OS of the total cohort and tumor size ≤7 cm subgroup. The patients who had an ALBI grade 1 presented a better survival time compared to those had an ALBI grade 2 in the total cohort.…”

Section: Discussionsupporting

confidence: 73%

Prognostic value of the ALBI grade among patients with single hepatocellular carcinoma without macrovascular invasion

Zou

Chen

Wang

et al. 2020

Preprint

Self Cite

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Overview and objective: Although evidence for the application of albumin–bilirubin (ALBI) grading system to assess liver function in hepatocellular carcinoma (HCC) is available, less is known whether it can be applied to determine the prognosis of single HCC with different tumor sizes. This study aimed to address this gap.Methods: Here, we enrolled patients who underwent hepatectomy due to single HCC from the year 2010 to 2014. Analyses were performed to test the potential of ALBI grading system to monitor the long-term survival of single HCC subjects with varying tumor sizes.Results: Overall, 265 participants were recruited. The overall survival (OS) among patients whose tumors were ≤ 7 cm was remarkably higher compared to those whose tumors were > 7 cm. The Cox proportional hazards regression model identified the tumor differentiation grade, ALBI grade, and maximum tumor size as key determinants of the OS. The ALBI grade could stratify the patients who had a single tumor ≤ 7 cm into two distinct groups with different prognoses. The OS between ALBI grades 1 and 2 was comparable for patients who had a single tumor > 7 cm.Conclusions: We show that ALBI grading system can predict disease outcomes of single HCC patients with tumor size ≤ 7 cm. However, the ALBI grade may not predict capability the prognosis of patients with single tumor > 7 cm.

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“…The ALBI score also correlated with recurrence of HCC after curative treatments, surgical resection, or ablative therapy . A risk of post‐hepatectomy liver failure and long‐term survival is stratified using the simple score . An ALBI score of <−2.600 indicates better prognosis, classified as grade 1, −2.600< ALBI score <−1.390 indicates moderate prognosis, classified as grade 2, and −1.390< ALBI score indicates worse prognosis, classified as grade 3.…”

Section: Discussionmentioning

confidence: 99%

Albumin–bilirubin score indicates liver fibrosis staging and prognosis in patients with chronic hepatitis C

Fujita

Oura

Yoneyama

et al. 2019

Hepatology Research

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Aim Albumin–bilirubin (ALBI) grade was investigated to predict prognosis of patients with cirrhosis. It was defined using the ALBI score calculated based on serum total bilirubin and albumin, which represent liver function. The diagnostic accuracy for liver fibrosis staging in patients with chronic hepatitis using the ALBI score has not been investigated well. This study aimed to evaluate the diagnostic abilities of the ALBI score for liver fibrosis staging in chronic hepatitis and cirrhosis in Japanese patients with hepatitis C virus (HCV) infection. Methods Japanese patients with HCV infection who underwent liver biopsy examinations were enrolled in a retrospective study. Fibrosis staging and activity grading were assessed using the modified METAVIR score. The ALBI score was calculated according to the following equation: Log10 total bilirubin (μmol/L) × 0.66 + albumin (g/L) × (−0.085). Results A total of 382 patients were enrolled in this study. The ALBI score differentiated fibrosis stage 4 from 3 and stage 3 from 2 (P < 0.05). When an ALBI score of −2.125 was adopted as a cut‐off value, the sensitivity and specificity were 73.2% and 87.1%, respectively, with a positive likelihood ratio of 5.67 to differentiate stage 4 from stages 1–3. Kaplan–Meier analysis showed that smaller ALBI scores at baseline correlated with better hepatocellular carcinoma (HCC)‐free and overall survival (P < 0.05). Conclusions The ALBI score indicates liver fibrosis staging in Japanese patients with HCV infection. Furthermore, smaller ALBI scores predict better HCC‐free survival and overall survival. The ALBI score has the potential to expand its application from cirrhosis to chronic hepatitis.

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Ability of the ALBI grade to predict posthepatectomy liver failure and long-term survival after liver resection for different BCLC stages of HCC

Cited by 55 publications

References 37 publications

Prognostic value of the ALBI grade among patients with single hepatocellular carcinoma without macrovascular invasion

Prognostic value of the ALBI grade among patients with single hepatocellular carcinoma without macrovascular invasion

Prognostic value of the ALBI grade among patients with single hepatocellular carcinoma without macrovascular invasion

Albumin–bilirubin score indicates liver fibrosis staging and prognosis in patients with chronic hepatitis C

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