Abiotic factors influencing podophyllotoxin and yatein overproduction in  Leptohyptis macrostachys  cultivated  in vitro

Meira, Paloma R.; David, Juceni P.; Ribeiro, Erika Maria de Oliveira; Santana, José Raniere Ferreira de; Brandão, Hugo Neves; Oliveira, Lenaldo Muniz de; David, Jorge M.; Medrado, Hector Hugo S.; Pastore, José Floriano Barêa

doi:10.1016/j.phytol.2017.10.016

Cited by 3 publications

(1 citation statement)

References 17 publications

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“…The in vitro propagation of Mesosphaerum suaveolens (syn. Hyptis suaveolens ) ( Bazaldúa et al, 2019 ; Velóz et al, 2013 ) and Leptohyptis macrostachys ( Meira et al, 2017 ) reached the goal, resulting in an increase in the production of podophyllotoxin ( 117 ) and yatein ( 113 ), in relation to the wild plants.…”

Section: Phytochemistrymentioning

confidence: 99%

Subtribe Hyptidinae (Lamiaceae): A promising source of bioactive metabolites

Bridi

Meirelles

Poser

2021

Journal of Ethnopharmacology

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Ethnopharmacological relevance The subtribe Hyptidinae contains approximately 400 accepted species distributed in 19 genera ( Hyptis , Eriope , Condea , Cantinoa , Mesosphaerum , Cyanocephalus , Hypenia , Hyptidendron , Oocephalus , Medusantha , Gymneia , Marsypianthes , Leptohyptis , Martianthus , Asterohyptis , Eplingiella , Physominthe , Eriopidion and Rhaphiodon ). This is the Lamiaceae clade with the largest number of species in Brazil and high rates of endemism. Some species have been used in different parts of the world mainly as insecticides/pest repellents, wound healing and pain-relief agents, as well as for the treatment of respiratory and gastrointestinal disorders. Aim of the review This review aims to discuss the current status concerning the taxonomy, ethnobotanical uses, phytochemistry and biological properties of species which compose the subtribe Hyptidinae. Materials and methods The available information was collected from scientific databases (ScienceDirect, Pubmed, Web of Science, Scopus, Google Scholar, ChemSpider, SciFinder ACS Publications, Wiley Online Library), as well as other literature sources (e.g. books, theses). Results The phytochemical investigations of plants of this subtribe have led to the identification of almost 300 chemical constituents of different classes such as diterpenes, triterpenes, lignans, α -pyrones, flavonoids, phenolic acids and monoterpenes and sesquiterpenes, as components of essential oils. Extracts, essential oils and isolated compounds showed a series of biological activities such as insecticide/repellent, antimicrobial and antinociceptive, justifying some of the popular uses of the plants. In addition, a very relevant fact is that several species produce podophyllotoxin and related lignans. Conclusion Several species of Hyptidinae are used in folk medicine for treating many diseases but only a small fraction of the species has been explored and most of the traditional uses have not been validated by current investigations. In addition, the species of the subtribe appear to be very promising as alternative sources of podophyllotoxin-like lignans which are the lead compounds for the semi-synthesis of teniposide and etoposide, important antineoplastic agents. Thus, there is a wide-open door for future studies, both to support the popular uses of the plants and to find new biologically active compoun...

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Section: Phytochemistrymentioning

confidence: 99%

Subtribe Hyptidinae (Lamiaceae): A promising source of bioactive metabolites

Bridi

Meirelles

Poser

2021

Journal of Ethnopharmacology

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Comparative metabolomic responses to gibberellic acid and 6-benzylaminopurine in Cunila menthoides Benth. (Lamiaceae): a contribution to understand the metabolic pathways

et al. 2018

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Gibberellic acid elicited synthesis of many phenols from different classes and enhanced production of sesquiterpenoids, polyterpenoids, steroids and monoterpenoids compared to control and 6-benzylaminopurine. Little is known about the effects of 6-benzylaminopurine (BA) and gibberellic acid (GA3) on the synthesis of secondary metabolites in species of Lamiaceae. In this study, for the first time, the profile of secondary metabolites in plantlets of Cunila menthoides was characterized, using UPLC-ESI-Qq-oaTOF-MS. Ninety metabolites were identified, including polyphenols and terpenes. BA down-regulated most of the identified molecules in relation to GA3 and MS0 (control). The results showed that GA3 elicited synthesis of many phenols from different classes, and seemed to play a major role in the shikimate pathway in relation to BA. GA3 enhanced production of sesquiterpenoids, polyterpenoids, steroids and monoterpenoids compared to MS0 and BA, and also seemed to positively influence the MEP/DOXP and MVA pathways. These data show the most comprehensive metabolomic profile of Cunila menthoides to date, and the effects of BA and GA3 on the synthesis of secondary metabolites, modulating quantitative aspects of metabolism in Lamiaceae.

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Biotic and abiotic stress roles in drugs production through in vitro approaches in plants – a review

Ahmed¹,

Kumar²,

Musthafa³

et al. 2020

AST

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Abstract. Plant metabolic engineering is a modern discipline that promises to create opportunities in pharmaceutical industries to produce and biomedicine. Over the long period natural and synthetic plant hormones have had tremendous implications in callus/cell culture /suspension/ for secondary metabolites production (SMs). Generally, SMs plays a vital fundamental role in protecting the plant from biotic and abiotic attacks to which it may be subjected. This review article focused on the relationship between various factors related to the drug production. In medicinal plants, in vitro studies, based on biotic factors such as fungal/endo-phytic fungal elicitors/microbe-derived exogenous elicitor yeast extract (YE) were cross checked with the abiotic six factor groups, including auxins and cytokinins, gamma radiation, lights, temperature, carbon sources, photoperiods, precursor chemicals and plant metabolic enzymes. Moreover, key enzymes and gene networks can serve as a resource to selected potential targets for specific SMs production. This is the first review to describe the light factors needed for the SM production, which has favorable role for SMs. We envisage that the researcher can design how to modulate the stress factors in terms of drug improvement from medicinal plants.

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Abiotic factors influencing podophyllotoxin and yatein overproduction in Leptohyptis macrostachys cultivated in vitro

Cited by 3 publications

References 17 publications

Subtribe Hyptidinae (Lamiaceae): A promising source of bioactive metabolites

Subtribe Hyptidinae (Lamiaceae): A promising source of bioactive metabolites

Comparative metabolomic responses to gibberellic acid and 6-benzylaminopurine in Cunila menthoides Benth. (Lamiaceae): a contribution to understand the metabolic pathways

Biotic and abiotic stress roles in drugs production through in vitro approaches in plants – a review

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