Ablación de la unión auriculoventricular en la fibrilación auricular refractaria a tratamiento farmacológico

Fatty amides (N-alkylamides) are a group of bioactive lipids widely distributed in microorganisms, animals, and plants. The low yield in the extraction process of spilantol, a grease amide, which has been related mainly to diverse biological effects, compromises its application on a large scale. Thus, this study proposed an alternative to the synthesis of fatty amides from Bertholletia excelsa (AGBe) oil, with a chemical structure similar to that of spilantol. In vivo models induced by carrageenan were used in Zebra sh (Danio rerio). In in vivo studies, oral AGBe produced no signs of toxicity. In the histopathological study, AGBe did not cause signi cant changes in the main metabolizing organs (liver, kidneys, and intestines). In the anti-in ammatory evaluation, all doses (45 mg/kg, 500 mg/kg, and 1000 mg/kg) were effective, signi cantly reducing edema and producing a dose-response effect when compared to spilantol. In the in silico study, with the use of molecular docking, he showed that among the AGBe, the molecules 18:1, ω-7-ethanolamine and 18:1, ω-9-ethanolamine stood out, which had 21 interactions for COX-2 and 20 interactions for PLA 2 , respectively, surpassing the spilantol standard with 15 interactions for COX-2 and PLA 2 . The hypothesis of anti-in ammatory action was con rmed in the in silico study, demonstrating the involvement of AGBe in the process of inhibiting the enzymes COX-2 and PLA 2 .Therefore, based on all the results obtained and the fact that until the dose of 1000 mg/kg, orally, in zebra sh, it was not possible to determine the LD 50 , it can be said that AGBe is effective and safe for the activity anti-in ammatory.

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Fatty ethanolamide of Bertholletia excelsa triglycerides (Brazil nuts): anti-inflammatory action and acute toxicity evaluation in Zebrafish (Danio rerio)

Quitian-Useche

Sánchez-Ortíz

Borges

et al. 2021

Inflammopharmacol

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Ablación de la unión aurículo-ventricular en pacientes con fibrilación auricular

Torrado

2000

Medicina Intensiva

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Estimulación permanente del haz de His tras ablación mediante radiofrecuencia del nodo auriculoventricular en pacientes con trastorno de la conducción suprahisiano

Vázquez

Pichardo

Gamero

et al. 2001

Revista Española de Cardiología

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Ablación de la unión auriculoventricular en la fibrilación auricular refractaria a tratamiento farmacológico

Cited by 3 publications

References 22 publications

Fatty ethanolamide of Bertholletia excelsa triglycerides (Brazil nuts): anti-inflammatory action and acute toxicity evaluation in Zebrafish (Danio rerio)

Fatty ethanolamide of Bertholletia excelsa triglycerides (Brazil nuts): anti-inflammatory action and acute toxicity evaluation in Zebrafish (Danio rerio)

Ablación de la unión aurículo-ventricular en pacientes con fibrilación auricular

Estimulación permanente del haz de His tras ablación mediante radiofrecuencia del nodo auriculoventricular en pacientes con trastorno de la conducción suprahisiano

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