he retrograde transaortic approach via a femoral artery or the transseptal approach via a femoral vein is widely used for endocardial catheterization [1][2][3][4][5] in the procedure of radiofrequency catheter ablation (RFCA) of left-sided atrioventricular accessory pathways (APs). Despite a high success rate, 2,4,5 puncture and cannulation of either the femoral artery or vein are required and complications, such as local hematoma, vagus reflex, and deep vein thrombosis of the lower limb caused by sheath-removal, compression for hemostasis or long-term restricted movement after the procedure, sometimes can not be avoided. 6,7 Catheter-based percutaneous coronary intervention (PCI) via the transradial approach is widely used for treating obstructive coronary artery disease, because of its safety, effectiveness and simplicity. [8][9][10][11][12][13][14] However, there has not been a systematic evaluation of the transradial approach for RFCA of left-sided APs in patients with type A WolffParkinson-White (WPW) syndrome.
MethodsThe study protocol was approved by the hospital's Ethical Committee. The possible risks and benefits of catheter ablation through a transradial approach were explained to each patient and/or family in detail and written informed consent was obtained before the patients were sent to the catheterization laboratory for the ablation procedure.
Patient PopulationWe evaluated 40 consecutive patients (26 men, 14 women, mean age 41±15 years) with type A WPW syndrome undergoing RFCA via the transradial approach. Left-sided APs were confirmed by electrophysiological study (EPS) and patients with coexisting right-sided APs were excluded from this study. All patients had a history of spontaneous symptomatic and sustained supraventricular tachycardia for an average of 8.8±4.7 years (range 3-18) and had been refractory to antiarrhythmic drugs for 2.3±0.8 years. Two patients had multiple syncope episodes because of atrial fibrillation with a fast ventricular rate. All patients had structurally and functionally normal hearts; none had stenosis or plaque in either the subclavian artery or carotid artery, confirmed by vascular ultrasound examination. The radial artery pulse was palpable and Allen's test was positive, indicating good collateral circulation of the ulnar and radial arteries.Data from another group of 30 patients with left APs who had previously undergone RFCA via the transfemoral approach were retrospectively reviewed as the controls. The baseline characteristics of the 2 groups were similar.
EPSEPSs were performed in the fasting state, with all antiarrhythmic agents having been withdrawn for at least 5 drug elimination half-lives before the procedure. After local anesthesia with 2% lidocaine, the right radial artery was punctured where the pulse was apparently palpable and a 6Fr arterial introducer sheath was inserted. A 0.035-inch (Received July 29, 2008; revised manuscript received December 4, 2008; accepted December 16, 2008; released online March 13, 2009