Abnormal association between reduced magnetic mismatch field to speech sounds and smaller left planum temporale volume in schizophrenia

Yamasue, Hidenori; Yamada, Hideaki; Yumoto, Masato; Kamio, Satoru; Kudo, Noriko; Uetsuki, Miki; Abe, Osamu; Fukuda, Ryouichi; Aoki, Shigeki; Ohtomo, Kuni; Iwanami, Akira; Kato, Nobuo; Kasai, Kiyoto

doi:10.1016/j.neuroimage.2004.01.042

Cited by 48 publications

(26 citation statements)

References 43 publications

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“…[22]), and recent magnetoencephalography (MEG) studies have suggested that schizophrenia patients are associated with left superior temporal cortical abnormality in phoneme perception [23,24]. In our study, however, the association between phoneme-duration MMN amplitude and auditory verbal memory performance was found in bilateral temporal electrodes.…”

Section: Discussioncontrasting

confidence: 87%

Phonetic mismatch negativity predicts verbal memory deficits in schizophrenia

et al. 2006

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Deficits in auditory sensory memory at the electrophysiological level as indexed by mismatch negativity and those in auditory verbal memory at the neuropsychological level have been independently demonstrated in previous studies of schizophrenia. We predicted a specific association between these indices in schizophrenia. Mismatch negativities elicited by change in tone duration and phoneme duration were recorded in 23 schizophrenia patients, who were also evaluated for auditory verbal memory and executive function. Lower amplitude of mismatch negativity under the phoneme-duration condition was significantly associated with worse verbal memory. Phoneme-duration mismatch negativity was not correlated with executive function, nor was tone-duration mismatch negativity correlated with verbal memory. These results suggest that electrophysiological auditory sensory memory dysfunction underlies the basis for neuropsychological auditory verbal memory deficits in schizophrenia.

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Section: Discussioncontrasting

confidence: 87%

Phonetic mismatch negativity predicts verbal memory deficits in schizophrenia

et al. 2006

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“…Furthermore, schizophrenia patients have a reduced MMN not only to changes in simple sound features but also to changes in speech sounds (Kasai et al, 2002a; for corroborating MEG results, see Kasai et al, 2002b;Yamasue et al, 2004). Yamasue et al (2004) also found that the phoneme-change MMNm strength in the left hemisphere correlated with the left planum temporale grey-matter volume in schizophrenia patients.…”

Section: Mmn Amplitude Reduction In Schizophreniamentioning

confidence: 59%

“…Yamasue et al (2004) also found that the phoneme-change MMNm strength in the left hemisphere correlated with the left planum temporale grey-matter volume in schizophrenia patients. This suggests that left-hemisphere structural planum-temporale abnormalities may underlie the functional abnormalities of fundamental language-related processing in schizophrenia patients.…”

Section: Mmn Amplitude Reduction In Schizophreniamentioning

confidence: 72%

Central auditory dysfunction in schizophrenia as revealed by the mismatch negativity (MMN) and its magnetic equivalent MMNm: a review

Näätänen

Kähkönen

2008

Int. J. Neuropsychopharm.

222

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Since the early 1990s, the auditory change-detection response, mismatch negativity (MMN) and its magnetoencephalographic (MEG) equivalent MMNm have been applied in a large number of studies on schizophrenia. These studies have enhanced our understanding of the central auditory dysfunction underlying schizophrenia. The attenuation of the MMN amplitude is a systematic and robust neurophysiological finding in these patients. The gradual attenuation of the MMN amplitude resulting from frequency change reflects the progress of the disease, particularly the impairment occurring as a function of illness duration, whereas the MMN deficiency for duration change may be more closely linked to the genetic aspect of the illness. Electroencephalographic (EEG) and magnetoencephalographic (MEG) studies, together, suggest that both the temporal and frontal cortices contributing to MMN generation are affected in schizophrenia patients. Furthermore, abnormalities in auditory perception and discrimination revealed by a deficient temporal MMN generator process might be associated with patients' positive symptoms, whereas the dampened frontal attention-switching function, suggested by the attenuated responses of the frontal MMN generator, might contribute to the negative symptoms such as social withdrawal. In addition, gradual MMN amplitude reduction, in particular that for frequency change, reflects cognitive and functional impairment occurring as a function of illness duration. Finally, as MMN can be detected even in animals such as the mouse, it might provide a useful biomarker for assessing the effects of the drugs developed to fight the cognitive and functional impairments in schizophrenia patients.

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“…Morphologic abnormalities of the superior temporal gyrus (STG) [21][22][23] and its functionally relevant subregions such as the primary auditory cortex (HG) [24][25][26] and planum temporale (PT), 24,[26][27][28][29] a neocortical language region, 30 have been repeatedly described in schizophrenia. Volume reduction of these regions, especially in the left hemisphere, have been found to correlate with auditory hallucinations or thought disorder.…”

Section: S Everal Lines Of Evidence Sup-mentioning

confidence: 99%