Phonetic mismatch negativity predicts verbal memory deficits in schizophrenia

Kawakubo, Yuki; Kasai, Kiyoto; Kudo, Noriko; Rogers, Mark A.; Nakagome, Kazuyuki; Itoh, Kenji; Kato, Nobuo

doi:10.1097/01.wnr.0000221828.10846.ba

Cited by 54 publications

(38 citation statements)

References 21 publications

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“…Stage 1 APS scores that were averaged across a range of auditory stimuli were further associated with executive functioning, whereas APS scores averaged across the entire hour of training (Hour 1 metrics) were also moderately associated with baseline verbal memory. These findings are consistent with previous research demonstrating relationships between auditory perception and performance in complex cognitive domains (Javitt, 2009; Kawakubo et al, 2006; Leitman et al, 2005; Light, Swerdlow, & Braff, 2007; Rissling et al, 2014). As evidenced by their moderate-to-strong associations with all cognitive domains, the composite metrics calculated after a full hour of training appear to provide a more robust indicator of auditory perceptual efficiency than do metrics derived from Level 1 or Stage 1.…”

Section: 1 Discussionsupporting

confidence: 93%

Measuring the capacity for auditory system plasticity: An examination of performance gains during initial exposure to auditory-targeted cognitive training in schizophrenia

Tarasenko

Perez

Pianka

et al. 2016

Schizophrenia Research

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Auditory-Targeted Cognitive Training (ATCT), which aims to improve auditory information processing efficiency, has shown great promise for remediating cognitive deficits in schizophrenia (SZ). However, there is substantial heterogeneity in the degree of cognitive gains made during ATCT, and some patients show negligible benefit after completing therapeutic doses of training. Identifying individual differences that can be measured early in the course of ATCT and that predict subsequent cognitive benefits from the intervention is therefore important. The present study calculated a variety of performance metrics during the initial hour of exposure to ATCT Sound Sweeps, a frequency discrimination time-order judgment task, and investigated the relationships of these metrics to demographic, clinical, and cognitive characteristics of SZ patients. Thirty-seven SZ outpatients completed measures of auditory attention, working memory, verbal memory, and executive functioning, followed by one hour of Sound Sweeps training. Performance metrics, calculated after the first training level, the first training stage (Levels 1–4), and the entire hour of training included baseline and best auditory processing speed (APS) scores, as well as percent improvement in APS after training. The number of training levels completed by each participant was also calculated. Baseline and best APS correlated with performance in all cognitive domains, whereas APS improvements only correlated with verbal memory. Number of training levels completed was marginally associated with auditory attention only. Conclusions Sound Sweeps performance correlates with a range of neurocognitive abilities. APS improvement may provide a particularly sensitive index of “plasticity potential” within the neural network underlying verbal learning and memory.

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Section: 1 Discussionsupporting

confidence: 93%

Measuring the capacity for auditory system plasticity: An examination of performance gains during initial exposure to auditory-targeted cognitive training in schizophrenia

Tarasenko

Perez

Pianka

et al. 2016

Schizophrenia Research

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“…As previously mentioned, medication did not abolish MMN abnormality in schizophrenia patients (Catts et al, 1995;Kasai et al, 2002c ;Kawakubo et al, 2006;Korostenskaja et al, 2005;Umbricht et al, 1998Umbricht et al, , 1999. Furthermore, this abnormality was present irrespective of the inter-stimulus interval (ISI), the deviant-stimulus probability, and the magnitude of stimulus change .…”

Section: Mmn Amplitude Reduction In Schizophreniamentioning

confidence: 85%

“…This suggests that left-hemisphere structural planum-temporale abnormalities may underlie the functional abnormalities of fundamental language-related processing in schizophrenia patients. In addition, Kawakubo et al (2006) found that a MMN deficit with respect to the duration decrement of a speech sound (but not of a sinusoidal tone) was associated with poor auditory verbal memory in schizophrenia patients.…”

Section: Mmn Amplitude Reduction In Schizophreniamentioning

confidence: 98%

Central auditory dysfunction in schizophrenia as revealed by the mismatch negativity (MMN) and its magnetic equivalent MMNm: a review

Näätänen

Kähkönen

2008

Int. J. Neuropsychopharm.

222

140

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Since the early 1990s, the auditory change-detection response, mismatch negativity (MMN) and its magnetoencephalographic (MEG) equivalent MMNm have been applied in a large number of studies on schizophrenia. These studies have enhanced our understanding of the central auditory dysfunction underlying schizophrenia. The attenuation of the MMN amplitude is a systematic and robust neurophysiological finding in these patients. The gradual attenuation of the MMN amplitude resulting from frequency change reflects the progress of the disease, particularly the impairment occurring as a function of illness duration, whereas the MMN deficiency for duration change may be more closely linked to the genetic aspect of the illness. Electroencephalographic (EEG) and magnetoencephalographic (MEG) studies, together, suggest that both the temporal and frontal cortices contributing to MMN generation are affected in schizophrenia patients. Furthermore, abnormalities in auditory perception and discrimination revealed by a deficient temporal MMN generator process might be associated with patients' positive symptoms, whereas the dampened frontal attention-switching function, suggested by the attenuated responses of the frontal MMN generator, might contribute to the negative symptoms such as social withdrawal. In addition, gradual MMN amplitude reduction, in particular that for frequency change, reflects cognitive and functional impairment occurring as a function of illness duration. Finally, as MMN can be detected even in animals such as the mouse, it might provide a useful biomarker for assessing the effects of the drugs developed to fight the cognitive and functional impairments in schizophrenia patients.

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“…14 Neurophysiological measures of early auditory information processing (EAP) in schizophrenia correlate with both cognition 22–24 and functional outcome 25–28 , can be feasibly measured across diverse settings 29 , and thus have promising applications as endophenotypes in genomic studies and as biomarkers in clinical outcome studies. 14,29–36 …”

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confidence: 99%

Modeling Deficits From Early Auditory Information Processing to Psychosocial Functioning in Schizophrenia

et al. 2017

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Importance Neurophysiological measures of early auditory information processing (EAP) are used as endophenotypes in genomic studies and biomarkers in clinical intervention studies. Research in schizophrenia has established correlations among measures of EAP, cognition, clinical symptoms, and functional outcome. Clarifying these relationships by determining the pathways through which deficits in EAP affect functioning would suggest when and where to therapeutically intervene. Objective We sought to characterize the pathways from EAP to outcome and to estimate the extent to which enhancement of basic information processing might improve both cognition and psychosocial functioning in schizophrenia. Design Cross-sectional data were analyzed using structural equation modeling to examine the associations between EAP, cognition, negative symptoms, and functional outcome. Setting Participants were recruited from the community at five geographically distributed laboratories as part of the Consortium on the Genetics of Schizophrenia-2 (COGS-2). Participants This well-characterized cohort of schizophrenia patients (N = 1,415) underwent EAP and cognitive testing as well as thorough clinical and functional assessment. Main Outcome and Measures EAP was measured by mismatch negativity, P3a, and reorienting negativity. Cognition was measured by the Letter Number Span test and scales from the California Verbal Learning Test - Second Edition, the Wechsler Memory Scale Third Edition, and the Penn Computerized Neurocognitive Battery. Negative symptoms were measured by the Scale for the Assessment of Negative Symptoms. Functional outcome was measured by the Role Functioning Scale. Results EAP had a direct effect on cognition (β = 0.37, p < .001), cognition had a direct effect on negative symptoms (β = −0.16, p < .001), and both cognition (β = 0.26, p < .001) and experiential negative symptoms (β = −0.75, p < .001) had direct effects on functional outcome. Overall, EAP had a fully mediated effect on functional outcome, engaging general rather than modality-specific cognition, with separate pathways that either involved or bypassed negative symptoms. Conclusions and Relevance The data support a model where EAP deficits lead to poor functional outcome via impaired cognition and increased negative symptoms. Results can be used to help guide mechanistically informed, personalized treatments, and support the strategy of using EAP measures as surrogate endpoints in early stage pro-cognitive intervention studies.

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Phonetic mismatch negativity predicts verbal memory deficits in schizophrenia

Cited by 54 publications

References 21 publications

Measuring the capacity for auditory system plasticity: An examination of performance gains during initial exposure to auditory-targeted cognitive training in schizophrenia

Measuring the capacity for auditory system plasticity: An examination of performance gains during initial exposure to auditory-targeted cognitive training in schizophrenia

Central auditory dysfunction in schizophrenia as revealed by the mismatch negativity (MMN) and its magnetic equivalent MMNm: a review

Modeling Deficits From Early Auditory Information Processing to Psychosocial Functioning in Schizophrenia

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