Abnormal asymmetry in benign epilepsy with unilateral and bilateral centrotemporal spikes: A combined fMRI and DTI study

Cao, Weifang; Zhang, Yaodan; Hou, Changyue; Yang, Fang; Gong, Jinnan; Jiang, Sisi; Huang, Yue; Xiao, Ruhui; Chen, Luo; Wang, Xiaoming; Yao, Dezhong

doi:10.1016/j.eplepsyres.2017.06.004

Cited by 17 publications

(16 citation statements)

References 41 publications

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“…Both decreases and increases of SMN connectivity strength have been observed. The interhemispheric connectivity strength between SMN regions appears to be weakened, a finding similar to that observed in language areas. Similarly, ReHo values appear to be increased in SMN regions, as is also observed in language areas .…”

Section: Functional Network In Cectssupporting

confidence: 75%

“…Two studies specifically examine the interhemispheric connectivity between left and right sensorimotor areas. In one study, there is a positive correlation between connectivity strength and performance and full‐scale IQ, although the other study observes the opposite . The remaining studies have tested for, but have not found, a significant correlation between connectivity results and cognitive developmental outcomes …”

Section: Functional Network In Cectsmentioning

confidence: 98%

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The epileptic network and cognition: What functional connectivity is teaching us about the childhood epilepsies

2019

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Our objective was to summarize and evaluate the rapidly expanding body of literature studying functional connectivity in childhood epilepsy. In the self‐limited childhood epilepsies, awareness of cognitive comorbidities has been steadily increasing, and recent advances in our understanding of the network effects of these disorders promise insights into the underlying neurobiology. We reviewed publications addressing functional connectivity in children with epilepsy with an emphasis on studies of children with self‐limited childhood epilepsies. The majority of studies have been published in the past 10 years and predominantly examine childhood epilepsy with centrotemporal spikes and childhood absence epilepsy. Cognitive network alterations are commonly observed across the childhood epilepsies. Some of these effects appear to be nonspecific to epilepsy syndrome or even to category of neurological disorder. Other patterns, such as changes in the connectivity of cortical language areas in childhood epilepsy with centrotemporal spikes, provide clues to the underlying cognitive deficits seen in affected children. The literature to date is dominated by general observations of connectivity patterns without a priori hypotheses. These data‐driven studies build an important foundation for hypothesis generation and are already providing useful insights into the neuropathology of the childhood epilepsies. Future work should emphasize hypothesis‐driven approaches and rigorous clinical correlations to better understand how the knowledge of network alterations can be applied to guidance and treatment for the children in our clinics.

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Section: Functional Network In Cectssupporting

confidence: 75%

Section: Functional Network In Cectsmentioning

confidence: 98%

The epileptic network and cognition: What functional connectivity is teaching us about the childhood epilepsies

2019

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“…For example, larger cortical gray matter volumes of sensorimotor cortices were observed in children with BECT compared to HC (Kim et al, 2015;Luo et al, 2015). DTI studies found reduced fractional anisotropy in the bilateral primary sensorimotor regions (Cao et al, 2017;Ciumas et al, 2014). Resting-state fMRI studies also reported reduced FC in the Rolandic areas (Luo et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

“…As the most common childhood idiopathic focal epilepsy syndrome, benign epilepsy with centrotemporal spikes (BECT) is characterized with the nocturnal epileptiform spikes arising from the rolandic or sensorimotor cortex. Although the epileptogenic zone of rolandic spikes originates from the rolandic cortex surrounding the central fissure, it can also lead to disturbances of the cortical and subcortical circuitry (Bouma, Bovenkerk, Westendorp, & Brouwer, ; Cao et al, ). As the white matter is the structural basis of the conduction of rolandic spikes, it can be hypothesized that the rolandic spikes also damaged the white matter.…”

Section: Introductionmentioning

confidence: 99%

“…Recently, Ciumas et al () demonstrated aberrant white‐matter microstructure in the precentral and postcentral gyri using the diffusion tensor imaging (DTI). Cao et al () indicated reduced white‐matter integrity between the corpus callosum and primary sensorimotor cortex in BECT. These neuroimaging studies provided evidence of structural abnormalities in the white matter to support this hypothesis.…”

Section: Introductionmentioning

confidence: 99%

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Dysfunctional white‐matter networks in medicated and unmedicated benign epilepsy with centrotemporal spikes

Jiang

et al. 2019

Human Brain Mapping

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Benign epilepsy with centrotemporal spikes (BECT) is the most common childhood idiopathic focal epilepsy syndrome, which characterized with white‐matter abnormalities in the rolandic cortex. Although diffusion tensor imaging research could characterize white‐matter structural architecture, it cannot detect neural activity or white‐matter functions. Recent studies demonstrated the functional organization of white‐matter by using functional magnetic resonance imaging (fMRI), suggesting that it is feasible to investigate white‐matter dysfunctions in BECT. Resting‐state fMRI data were collected from 24 new‐onset drug‐naive (unmedicated [NMED]), 21 medicated (MED) BECT patients, and 27 healthy controls (HC). Several white‐matter functional networks were obtained using a clustering analysis on voxel‐by‐voxel correlation profiles. Subsequently, conventional functional connectivity (FC) was calculated in four frequency sub‐bands (Slow‐5:0.01–0.027, Slow‐4:0.027–0.073, Slow‐3:0.073–0.198, and Slow‐2:0.198–0.25 Hz). We also employed a functional covariance connectivity (FCC) to estimate the covariant relationship between two white‐matter networks based on their correlations with multiple gray‐matter regions. Compared with HC, the NMED showed increased FC and/or FCC in rolandic network (RN) and precentral/postcentral network, and decreased FC and/or FCC in dorsal frontal network, while these alterations were not observed in the MED group. Moreover, the changes exhibited frequency‐specific properties. Specifically, only two alterations were shared in at least two frequency bands. Most of these alterations were observed in the frequency bands of Slow‐3 and Slow‐4. This study provided further support on the existence of white‐matter functional networks which exhibited frequency‐specific properties, and extended abnormalities of rolandic area from the perspective of white‐matter dysfunction in BECT.

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Interhemispheric functional connectivity asymmetry is distinctly affected in left and right mesial temporal lobe epilepsy

Zhao

Zhou

et al. 2022

Brain and Behavior

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Introduction:The differences of functional connectivity (FC) and functional asymmetry between left and right mesial temporal lobe epilepsy with hippocampal sclerosis (LMTLE and RMTLE) have not been completely clarified yet. The purpose of the present study is to investigate the FC changes and the FC asymmetric patterns of MTLE, and to compare the differences in FC and functional asymmetry between LMTLE and RMTLE. Methods: In total, 12 LMTLE, 11 RMTLE patients, and 23 healthy controls (HC) were included. Region of interest (ROI)-based analysis was used to evaluate FC. The right functional connectivity (rFC) and left functional connectivity (lFC) of each ROI were calculated. Asymmetry index (AI) was calculated based on the following formula: AI = 100 × (rFC − lFC)∕[(rFC + lFC)∕2]. Paired t-test and univariate analysis of variance were used to analyze FC asymmetry. Linear correlation analysis was performed between significant FC changes and lateralized ROIs and epilepsy onset age and duration.Results: LMTLE and RMTLE patients showed different patterns of alteration in FC and functional asymmetry when compared with controls. RMTLE presented more extensive FC abnormalities than LMTLE. Regions in ipsilateral temporal lobe presented as central regions of abnormalities in both patient groups. In addition, the asymmetric characteristics of FC were reduced in MTLE compared with HC, with even more pronounced reduction for RMTLE group. Meanwhile, ROIs presented FC AI differences among the three groups were mostly involving left temporal lobe (L_hippo, L_amyg, L_TP, L_aMTG, and L_pTFusC). No correlation was found between significant FC changes and lateralized ROIs and epilepsy onset age and duration. Conclusion:The FC and asymmetric features of MTLE are altered and involve both the temporal lobe and extra-temporal lobe. Furthermore, the altered FC and asymmetric features were distinctly affected in LMTLE and RMTLE compared to controls.

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Abnormal asymmetry in benign epilepsy with unilateral and bilateral centrotemporal spikes: A combined fMRI and DTI study

Cited by 17 publications

References 41 publications

The epileptic network and cognition: What functional connectivity is teaching us about the childhood epilepsies

The epileptic network and cognition: What functional connectivity is teaching us about the childhood epilepsies

Dysfunctional white‐matter networks in medicated and unmedicated benign epilepsy with centrotemporal spikes

Interhemispheric functional connectivity asymmetry is distinctly affected in left and right mesial temporal lobe epilepsy

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