Abnormal brain functional and structural connectivity between the left supplementary motor area and inferior frontal gyrus in moyamoya disease

Hu, Jinwen; Li, Yin; Li, Zhaoqing; Chen, Jingyin; Cao, Yang; Xu, Duo; Zheng, Leilei; Bai, Ruiliang; Wang, Lin

doi:10.1186/s12883-022-02705-2

Cited by 8 publications

(3 citation statements)

References 36 publications

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“…Impairment in functional connectivity in patients with symptomatic MMD has been demonstrated in resting-state functional MRI studies [2][3][4]. With the enhanced awareness of physical examination and advances in noninvasive magnetic resonance methods, the early detection of asymptomatic patients with MMD who have not experienced CVAs is possible [5].…”

Section: Introductionmentioning

confidence: 99%

Atrophy in subcortical gray matter in adult patients with moyamoya disease

Zuo¹,

Guo²,

Chen³

et al. 2023

Neurol Sci

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Background Acute cerebrovascular accidents, long-term hypoperfusion, and/or remote neuronal degeneration may lead to structural alterations in patients with moyamoya disease (MMD). This study sought to comprehensively investigate the distribution characteristics of subcortical gray matter volume and their correlations with angiographic changes in the intracranial artery in patients with MMD. Method One hundred forty-two patients with MMD and 142 age- and sex-matched healthy controls underwent 3-dimensional high-resolution structural magnetic resonance imaging. Volumes of subcortical gray matter and subregions of the hippocampus and amygdala were calculated, and the degree of stenosis/occlusion of intracranial arteries in patients with MMD was evaluated on MR angiography. Results Volume reductions in the thalamus, caudate, putamen, hippocampus, amygdala, pallidum, and nucleus accumbens were found in patients with MMD. Hippocampal subfields and amygdala subnuclei in patients with MMD showed distinct vulnerability, and morphological alterations in specific subregions were more obvious than in the whole hippocampus/amygdala. Volume loss in several subcortical areas was related to disease duration and intracranial arterial changes. Conclusions Our findings revealed structural alteration patterns of subcortical gray matter in MMD. The specific atrophy in subregions of the hippocampus and the amygdala suggested potential cognitive and affective impairments in MMD, which warrants further investigation. Chronic cerebral hemodynamic alterations in MMD may play a pivotal role in morphological changes in subcortical areas.

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Section: Introductionmentioning

confidence: 99%

Atrophy in subcortical gray matter in adult patients with moyamoya disease

Zuo¹,

Guo²,

Chen³

et al. 2023

Neurol Sci

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“…Recent studies have shown that progression of the MMD can cause damage to the brain regions responsible for speech and language, leading to a variety of dysfunctions. In particular, the disease has been associated with damage to the frontal and temporal lobes, which play key roles in speech production and comprehension (Hu et al, 2022;Saito et al, 2021). The study by Zuo and colleagues showed that nearly 30% of patients (in a sample of 142 individuals) with moyamoya disease had speech impairments in the form of dysarthria and aphasia (Zuo et al, 2023).…”

Section: Introductionmentioning

confidence: 99%

Profile of speech and cognitive impairments in a patient with moyamoya disease: a longitudinal case study

Pashkov,

Filimonova,

Martirosyan

et al. 2023

Preprint

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Moyamoya is a rare chronic brain vascular disease with a set of potential life-threatening consequences due to a high probability of stroke occurrence. Patients suffering from this disease are often presented with diverse and severe sensory, motor and cognitive deficits, which often lead to general inability to work and, in the most severe cases, to complete loss of self-serving skills and gross disturbance of vital homeostatic functions. Here we present a case of a patient with moyamoya disease, who has been dynamically observed over more than 4 years after the first manifestation of her symptoms. We have been tracking the appearance of patient’s new symptoms and resolution of existing ones after neurosurgical treatment (revascularization surgery) with in-depth neurological examination, neuropsychological assessment and fMRI/DTI sessions. This study represents one of the first attempts to rigorously estimate the patterns of deficits at different levels, connecting neural circuits affected by the disease to behavior. Our findings lend further support to the idea that revascularization surgery can improve cognitive performance and highlights the importance of long-term follow-up in understanding the effects of surgery on brain function.

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“…A 'network pathophysiological model' of dystonia has been proposed, in which multiple lesions in and outside the basal ganglia and defective interactions among different nodes in the motor network can produce dystonia [25]. In addition, abnormal inhibitory control of the motor cortex from the frontal cortex suppression frontal was found in various diseases [26]. Therefore, the present study hypothesized changed role of the frontal regions in the motor network might be related to the etiology of Meige and the main difference between these two disorders.…”

Section: Introductionmentioning

confidence: 99%

Higher betweenness and degree centrality in the frontal and cerebellum cortex of Meige’s syndrome patients than hemifacial spasm patients

et al. 2022

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Meige’s syndrome and hemifacial spasm (HFS) are two different forms of dystonic movement disorder, but their difference in terms of resting state functional connectivity (rsFC) remains unclear. The present study applied resting state fMRI on the patients and quantified their functional connectivity with graph theoretical measures, including the degree centrality and the betweenness centrality. Fifteen Meige’s syndrome patients and 19 HFS patients matched in age and gender were recruited and their MRI data were collected. To analyze the rsFC, we adopted the Anatomical Automatic Labeling (AAL) template, a brain atlas system including 90 regions of interest (ROIs) covering all the brain regions of cerebral cortex. For each participant, the time-course of each ROI was extracted, and the corresponding degree centrality and betweenness centrality of each ROI were computed. These measures were then compared between the Meige’s syndrome patients and the HFS patients. Meige’s syndrome patients showed higher betweenness centrality and degree centrality of bilateral superior medial frontal cortex, the left cerebellum cortex, etc. than the HFS patients. Our results suggest that the rsFC pattern in Meige’s syndrome patients might become more centralized toward the prefrontal and vestibular cerebellar systems, indicating less flexibility in their functional connections. These results preliminarily revealed the characteristic abnormality in the functional connection of Meige’s patients and may help to explore better treatment.

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Abnormal brain functional and structural connectivity between the left supplementary motor area and inferior frontal gyrus in moyamoya disease

Cited by 8 publications

References 36 publications

Atrophy in subcortical gray matter in adult patients with moyamoya disease

Atrophy in subcortical gray matter in adult patients with moyamoya disease

Profile of speech and cognitive impairments in a patient with moyamoya disease: a longitudinal case study

Higher betweenness and degree centrality in the frontal and cerebellum cortex of Meige’s syndrome patients than hemifacial spasm patients

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