2022
DOI: 10.1177/0271678x221121872
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Abnormal cerebral microvascular perfusion and reactivity in female offspring of reduced uterine perfusion pressure (RUPP) mice model

Abstract: Children born from women with preeclampsia have alterations in cerebral neurovascular development and a high risk for developing cognitive alterations. Because cerebral blood vessels are critical components in cerebrovascular development, we evaluated the brain microvascular perfusion and microvascular reactivity (exposed to external stimuli of warm and cold) in pups born to preeclampsia-like syndrome based on the reduction of uterine perfusion (RUPP). Also, we evaluate the angiogenic proteomic profile in thos… Show more

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Cited by 8 publications
(13 citation statements)
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“…44 The apparent disparity between these findings may be associated with differences in the PELS model used to study the offspring. In this regard, to overcome the potential bias generated using L-NAME, we confirmed the finding of reduced brain angiogenesis in 2 additional mouse models, the RUPP model 10 and the genetic C1q model of preeclampsia. 39 It is unclear whether this reduction in the brain angiogenesis has functional implications in the offspring; however, previous findings using offspring from L-NAME-treated pregnant rats 45 or in mice in which alterations in brain angiogenesis were due to 16p11.2 deletion (as a model of autism), 46 or deletion of PlGF, 47 have demonstrated severe behavioral and cognitive alterations in the offspring.…”
Section: Discussionsupporting
confidence: 68%
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“…44 The apparent disparity between these findings may be associated with differences in the PELS model used to study the offspring. In this regard, to overcome the potential bias generated using L-NAME, we confirmed the finding of reduced brain angiogenesis in 2 additional mouse models, the RUPP model 10 and the genetic C1q model of preeclampsia. 39 It is unclear whether this reduction in the brain angiogenesis has functional implications in the offspring; however, previous findings using offspring from L-NAME-treated pregnant rats 45 or in mice in which alterations in brain angiogenesis were due to 16p11.2 deletion (as a model of autism), 46 or deletion of PlGF, 47 have demonstrated severe behavioral and cognitive alterations in the offspring.…”
Section: Discussionsupporting
confidence: 68%
“…Our findings indicate that reduced brain blood perfusion observed in children of mothers with preeclampsia 11 and pups of PELS 10 is likely associated with reduced brain cortex angiogenesis. These findings contribute to our understanding of structural, behavioral, and cognitive alterations described in children born from women with preeclampsia.…”
Section: Discussionmentioning
confidence: 65%
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