Children born from women with preeclampsia have alterations in cerebral neurovascular development and a high risk for developing cognitive alterations. Because cerebral blood vessels are critical components in cerebrovascular development, we evaluated the brain microvascular perfusion and microvascular reactivity (exposed to external stimuli of warm and cold) in pups born to preeclampsia-like syndrome based on the reduction of uterine perfusion (RUPP). Also, we evaluate the angiogenic proteomic profile in those brains. Pregnant mice showed a reduction in uterine flow after RUPP surgery (−40 to 50%) associated with unfavorable perinatal results compared to sham mice. Furthermore, offspring of the RUPP mice exhibited reduced brain microvascular perfusion at postnatal day 5 (P5) compared with offspring from sham mice. This reduction was preferentially observed in females. Also, brain microvascular reactivity to external stimuli (warm and cold) was reduced in pups of RUPP mice. Furthermore, a differential expression of the angiogenic profile associated with inflammation, extrinsic apoptotic, cancer, and cellular senescence processes as the primary signaling impaired process was found in the brains of RUPP-offspring. Then, offspring (P5) from preeclampsia-like syndrome exhibit impaired brain perfusion and microvascular reactivity, particularly in female mice, associated with differential expression of angiogenic proteins in the brain tissue.

We develop an analytical framework in which a natural-resource-extracting firm pays an incumbent politician both legal and illegal bribes in exchange for reductions in the severance tax rate. A positive resource shock increases the marginal benefit of a tax cut and more bribes are given. We test this theory using forty years of U.S. statelevel data, measuring legal corruption as contributions to political campaigns from the oil and gas sector, and illegal corruption as both convictions of public corruption and "reflections" of it, measured as the frequency that words like "corrupt", "fraud", and "bribery"-and their iterations-appear in local newspapers. We find that oilrich U.S. states are significantly more corrupt than their oil-poor counterparts and that this is especially true during periods of high oil prices, suggesting an underlying causal relationship. Our findings are robust to a variety of modeling assumptions and specifications suggesting that oil-through its effect on political corruption-plays an indirect, critically important, and yet previously overlooked role in shaping public and economic outcomes in the United States.

No abstract

Driving restrictions are a common governmental strategy to reduce airborne pollution and traffic congestion in many cities of the world. Using high-frequency data on air pollution, car trips, and mass-transit systems ridership, I evaluate the effectiveness of temporary driving bans triggered by air quality warnings in Santiago, Chile. I employ a fuzzy regression discontinuity design that uses the thresholds in the air quality index used to announce these warnings as instruments for their announcement. Results show that these temporary bans reduce car trips by 6-9% during peak hours, and by 7-8% during off-peak hours. This is consistent with air pollution reductions during peak hours, and with increases in the use of Santiago's mass-transit systems during hours the systems run with excess capacity. Increments in mass-transit ridership uncover the importance of alternatives modes of transportation in securing the effectiveness of temporary driving bans.