Abnormal change of paravertebral muscle in adult degenerative scoliosis and its association with bony structural parameters

Xie, Dongxiao; Zhang, Jinniu; Ding, Wenyuan; Yang, Sidong; Yang, Dalong; Ma, Lei; Zhang, Jingtao

doi:10.1007/s00586-019-05958-7

Cited by 38 publications

(44 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, a association was identified between the CDI of the multifidus at the apical vertebral level and the Cobb angle of lumbar scoliosis (P= 0.028; Table II). It was indicated that the volume of the multifidus was closely associated with the degree of lumbar scoliosis (21). The FIR of the multifidus was also significantly higher on the concave side compared with that on the convex side at the apical vertebral level (1.48 fold-change vs. the convex side), but this difference was not statistically significant for the erector spinae or psoas major ( Fig.…”

Section: Resultsmentioning

confidence: 89%

Assessment of the association between paraspinal muscle degeneration and quality of life in patients with degenerative lumbar scoliosis

et al. 2020

View full text Add to dashboard Cite

The present study aimed to determine the characteristics of multifidus, erector spinae and psoas major degeneration in elderly patients with degenerative lumbar scoliosis (DLS) and the correlation between asymmetric changes and patient quality of life. A total of 49 patients with lumbar scoliosis (DLS group) and 38 healthy individuals (control group) were prospectively examined. The functional cross-sectional area, cross-sectional area difference index (CDI) and fat infiltration rate (FIR) of the multifidus, erector spinae and psoas major at the apical vertebral level were measured using MRI. The visual analogue scale (VAS) score, Oswestry Disability Index (ODI) and 36-item Short Form Health Survey (SF-36) score were used to evaluate patient quality of life. Correlations between the degree of asymmetric muscular degeneration and quality of life were analysed. The CDI of the multifidus, erector spinal and psoas major was higher in the DLS group compared with that in the control group. The CDI of the multifidus was found to be positively associated with the Cobb angle of lumbar scoliosis. Similar results were obtained for fat infiltration between the two groups. In addition, the CDI and FIR difference index of the multifidus was positively correlated with the VAS score and ODI but negatively correlated with the SF-36 score. The quality of life significantly decreased with increasing asymmetric atrophy and fat infiltration in the multifidus. Thus, strategies to enhance the function of the multifidus may have a positive impact on quality of life (Chinese Clinical Trial Registry, registration date, 2018.11.12; registration no. ChiCTR1800019459.).

show abstract

Section: Resultsmentioning

confidence: 89%

Assessment of the association between paraspinal muscle degeneration and quality of life in patients with degenerative lumbar scoliosis

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The percentage of fat infiltration areas in paraspinal muscles was significantly higher on the concave side than the convex side. Further the asymmetry of the multifidus muscle change is positively correlated with the lumbar curvature, lateral vertebral translation, and apical vertebral rotation [60].…”

Section: Advanced Clinical Imagingmentioning

confidence: 90%

“…MRI may also reveal a reduction in muscle mass in the lumbar paraspinal muscles in patients with DLS [59,60].as paraspinal muscles are involved in the stability of the lumbar spine; Barker et al [59] suggested that their atrophy was associated with lumbar instability [59]. The percentage of fat infiltration areas in paraspinal muscles was significantly higher on the concave side than the convex side.…”

Section: Advanced Clinical Imagingmentioning

confidence: 99%

Conservative Treatment of Degenerative Lumbar Scoliosis

Ng¹

2021

Spinal Deformities in Adolescents, Adults and Older Adults

View full text Add to dashboard Cite

Degenerative lumbar scoliosis (DLS) is commonly seen in people over the age of 50 years. The prevalence increases with age. Patients with DLS often complain of low back pain and radiculopathy. Neurological complaints are rare. Current treatments are generally targeted at pain relief. Effects are temporary; this is understandable as the spinal deformities which are the cause of the pain are not addressed. A few studies have shown that scoliosis specific exercises and lordotic bracing stabilize or reduce the rate of curve progression in patients with DLS. Patients should also be instructed in performing corrective movements in daily activities. In the presence of sarcopenia or decreased bone mineral density (BMD), resistance exercises and nutritional supplements should also be prescribed, as reduction in paraspinal muscle mass and BMD are risk factors of DLS. In the presence of neurological involvement or when the symptoms are refractory to conservative treatment, referral for surgery is required.

show abstract

“…The etiology of IS is linked to many factors; studies support that spinal deformity may be associated with PVM atrophy. PVM lesion is more often observed on the concave side among patients with IS, which is positively connected with the progression of IS [ 6 ]. The muscle thickness was significantly greater on the concave side of the curve compared with the control's dominant side [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, asymmetric loading on the spinal column may play roles in the onset and development of IS. The structures stabilizing the spine, including paravertebral muscle (PVM), have been suggested as implicated in the pathology of IS [5,6].…”

Section: Introductionmentioning

confidence: 99%

Exploring the Pathological Role of Collagen in Paravertebral Muscle in the Progression of Idiopathic Scoliosis

Peng

Jin

Meng

et al. 2020

BioMed Research International

View full text Add to dashboard Cite

Background. Paravertebral muscle (PVM) is considered as a contributing factor of idiopathic scoliosis (IS); collagen is crucial for maintaining the mechanical properties of PVM, but only a few researches have described this field. In this study, we observed the muscle stiffness of PVM and the curvature of the spine by adjusting the content of collagen in PVM of rats and explored the role of collagen in the progression of IS. Methods. 32 female Sprague Dawley rats were randomly divided into four groups: neutralizing antibody (NA) group (group 1), normal control group (group 2), IS group (group 3), and IS with NA group (group 4). TGF-β1 NA was injected into PVM in group 1 and group 4, while Normal saline in group 2 and group 3. The Cobb angle and muscle stiffness were measured before and after injection; the rats were sacrificed at one week after injection, and performed histological, Western Blot, and qRT-PCR examinations. Results. X-rays showed that scoliosis occurred in group 1 and relieved in group 4. The stiffness of PVM was decreased significantly on the convex side in group 1, while on the concave side in group 4. The expression of TGF-β1 and COL1 on the concave side in IS rats (group 3) was significantly increased than that in normal rats (group 2), the concentration of COL1 and COL3 in group 3 was significantly higher than that in group 2, and the addition of TGF-β1 NA significantly downregulated COL1 and COL3 in group 1 and group 4. The concentration of COL1 in convex PVM was negatively related to Cobb angle in group 1 and group 2, and in concave PVM was positively related to Cobb angle in group 3 and group 4. However, no significant correlation was found between COL3 and Cobb angle in group 3 and group 4. Conclusions. Asymmetric biomechanical characteristics of PVM was an important etiological factor of IS, which was directly correlated with collagen, it could be adjusted by local intramuscular injecting of TGF-β1 NA, and finally had an effect on the shape of the spine.

show abstract

Abnormal change of paravertebral muscle in adult degenerative scoliosis and its association with bony structural parameters

Cited by 38 publications

References 47 publications

Assessment of the association between paraspinal muscle degeneration and quality of life in patients with degenerative lumbar scoliosis

Assessment of the association between paraspinal muscle degeneration and quality of life in patients with degenerative lumbar scoliosis

Conservative Treatment of Degenerative Lumbar Scoliosis

Exploring the Pathological Role of Collagen in Paravertebral Muscle in the Progression of Idiopathic Scoliosis

Contact Info

Product

Resources

About